RETRACTED ARTICLE: MIR600HG sponges miR-125a-5p to regulate glycometabolism and cisplatin resistance of oral squamous cell carcinoma cells via mediating RNF44

Liu, Xingguang; Zhao, Tengda; Yuan, Zhe; Ge, Shaohua

doi:10.1038/s41420-022-01000-w

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…In several human cancer types, including medulloblastoma, and lung, ovarian and breast cancer, the expression of miR125a-5p is downregulated ( 128 ). In oral squamous cell carcinoma, miR-125a-5p expression is also markedly downregulated ( 129 ). These findings indicate that miR-125a-5p may function as a tumor suppressor.…”

Section: Mirnas In Accmentioning

confidence: 99%

MicroRNA in adenoid cystic carcinoma (Review)

et al. 2022

Int J Oncol

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Adenoid cystic carcinoma (ACC) usually arises in the salivary glands, and is a rare tumor, accounting for 1% of all head and neck cancer cases. According to estimates, there are 3-4.5 cases of ACC for every one million individuals. Numerous studies have reported the association between ACC and microRNAs (miRNAs/miRs). miRNAs are endogenous, non-coding small RNAs, 19-25 nt in length, that can regulate target gene expression at the post-transcriptional level. The aberrant expression of miRNAs may be associated with the prognosis and treatment of patients, as well as with tumorigenesis and tumor development. miRNAs are becoming reliable biomarkers for disease detection due to their varied characteristics, and miRNA target-based therapies are increasingly being used in clinical practice. The present review provides a brief introduction to ACC and the biogenesis of miRNAs. A summary of the miRNAs that have been validated by in vitro or in vivo studies is then presented, describing their role in ACC. Contents1. Introduction 2. Clinical features 3. Histopathology and diagnostic imaging 4. Treatment 5. Biogenesis of miRNAs 6. miRNAs in ACC 7. Conclusions and future perspectives

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Section: Mirnas In Accmentioning

confidence: 99%

MicroRNA in adenoid cystic carcinoma (Review)

et al. 2022

Int J Oncol

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“…However, recent studies have confirmed that lncRNAs are involved in processes such as X chromosome silencing, chromosomal and genome modification, transcriptional activation, transcriptional perturbation, and nuclear transport, and play important regulatory roles in many aspects of tumor pathology. At the same time, it can also play a role in tumor diagnosis and treatment by promoting or inhibiting the development of cancer [7,8]. A previous study reported that LncRNAs play a role in thyroid cancer by targeting microRNA (MiRNA) blockade [9].…”

Section: Introductionmentioning

confidence: 99%

Construction of a model for predicting the prognosis of liver cancer patients based on CuProtosis-related LncRNA

Chen¹,

Zhou²,

Gong³

et al. 2022

Iberoam J Med

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Introduction: Liver cancer is one of the most common malignant tumors in the world, and patients with liver cancer are often in the middle and late stages of cancer when they are diagnosed. Copper death is a newly discovered new cell death method. It is a copper-dependent and regulated cell death method. At the same time, Long noncoding RNAs (LncRNAs) also play an important regulatory role in the pathological process of tumors such as liver cancer. Materials and methods: First, the expression levels of CuProtosis-related genes in liver cancer samples were extracted, and a CuProtosis- related LncRNA prognostic model was constructed. C-index curve and ROC curve were drawn by survival analysis, PFS analysis, and independent prognosis analysis. The model was also validated by clinical grouping and PCA principal component analysis. To ensure its accuracy, enrichment analysis, immune analysis and tumor mutational burden analysis further explored the potential function of this model, and finally discussed potential drugs targeting this model. Results: A prognostic model for predicting survival was constructed and its high predictive ability in liver cancer patients was validated. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment showed that the differential genes were mainly enriched in 5 pathways. Meanwhile, six differentially expressed immune functions were found in the high-risk and low-risk groups. The survival rate of patients in the high mutation group was significantly lower than that of the patients with liver cancer in the low mutation group. Twelve drugs with significant differences in drug sensitivity between high- and low-risk groups were explored. Conclusions: The risk-prognosis model based on CuProtosis LncRNA established in this study is expected to be used to predict the prognosis and immunotherapy response of liver cancer patients. It provides new clues and methods for predicting the survival time of liver cancer patients, and also provides new ideas for guiding individualized immunotherapy strategies for liver cancer patients in the future.

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A combination of cuproptosis and lncRNAs predicts the prognosis and tumor immune microenvironment in cervical cancer

Huang,

Pan,

et al. 2024

Discov Onc

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Background Cuproptosis induces proteotoxic stress and eventually leads to cell death. However, the relationship between cuproptosis and lncRNAs in cervical cancer has not been fully elucidated. Therefore, we aim to explore the association among lncRNAs, cuproptosis and clinical features in cervical cancer. Methods RNA sequencing, genetic mutations, and clinical data of CESC patients were obtained from TCGA. Cuproptosis-associated genes were gathered. WGCNA was used to cluster important modules, and KEGG, GO, GSEA and GSVA were used to explore functional and pathway enrichment. The association between immune microenvironment and cuproptosis-related lncRNAs was performed by using cibersort algorithm and other platforms, including XCELL, TIMER, QUANTISEQ, MCPCOUNTER and EPIC. Fluorescence quantitative PCR was employed to detect the expression of LINC01833 and LINC02321, and CCK-8 and cell scratch assays were used to assess cell proliferation and migration capabilities after LINCRNA interference. Results 202 upregulated and 45 downregulated lncRNAs were selected. The survival analysis showed that there was a statistically significant difference in survival rates between the high-risk and low-risk groups. The prognosis of tumour mutation burden and the degree of immune infiltration were differed noticeably between the high-risk and low-risk groups. BHG712, TL-2-105, FR-180204, Masitinib, TAK-715, ODI-027, JW-7-24-2, and OSI-930 had substantially higher IC50 values in the high-risk group. Notably, we found AL360178.1 was associated with RNF44 E3 ubiquitin ligase expression. In cervical cancer cell lines, LINC01833 and LINC02321 displayed significant upregulation. Efficient siRNA transfection led to a decreased expression of LINC01833 and LINC02321. This knockdown significantly hindered both cell proliferation and migration capabilities in cervical cancer cells compared to the negative control. Conclusion In conclusion, we constructed five cuprotosis-related lncRNA prognostic models, which may be new tumor therapeutic targets for the prevention and treatment of cervical cancer.

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RETRACTED ARTICLE: MIR600HG sponges miR-125a-5p to regulate glycometabolism and cisplatin resistance of oral squamous cell carcinoma cells via mediating RNF44

Cited by 6 publications

References 36 publications

MicroRNA in adenoid cystic carcinoma (Review)

MicroRNA in adenoid cystic carcinoma (Review)

Construction of a model for predicting the prognosis of liver cancer patients based on CuProtosis-related LncRNA

A combination of cuproptosis and lncRNAs predicts the prognosis and tumor immune microenvironment in cervical cancer

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