RETRACTED ARTICLE: miR-23a promotes IKKα expression but suppresses ST7L expression to contribute to the malignancy of epithelial ovarian cancer cells

Yang, Zhen; Wang, Xiangling; Bai, Ru; Liu, Weiying; Li, Xin; Liu, Min; Tang, Hua

doi:10.1038/bjc.2016.244

Cited by 53 publications

(39 citation statements)

References 41 publications

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“…Inactivation of Wnt/β-catenin signaling caused by ST7L by repressing β-catenin expression could explain this phenomenon to a certain extent in epithelial ovarian cancer ( 21 ). To address these issues, the expression of Wnt genes and the activity of β-catenin were analyzed in the context of miR-378 overexpression or miR-378 overexpression in conjunction with pST7L in cervical cancer cells.…”

Section: Resultsmentioning

confidence: 99%

“…Suppression of tumorigenicity 7-like (ST7L) was identified based on its similarity to the ST7 tumor suppressor gene ( 18 ). ST7L is downregulated in different cancers, including gastric cancer ( 19 ), glioma ( 20 ), ovarian cancer ( 21 ) and hepatocellular carcinoma ( 22 ). For example, Chen et al ( 20 ) demonstrated that the deletion of miR-24 suppressed β-catenin/Tcf-4 transcription activity by targeting ST7L in glioma.…”

Section: Introductionmentioning

confidence: 99%

“…For example, Chen et al ( 20 ) demonstrated that the deletion of miR-24 suppressed β-catenin/Tcf-4 transcription activity by targeting ST7L in glioma. In addition, Yang et al ( 21 ) reported that upregulated miR-23a promoted cell malignant phenotype by targeting ST7L in epithelial ovarian cancer cells. Recently, Zhuang et al ( 22 ) indicated that ST7L could interact with the carboxyl terminal region of AKT and suppress AKT/GSK3β/β-catenin pathway in HCC cells.…”

Section: Introductionmentioning

confidence: 99%

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miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer

Yang

Wang

et al. 2017

International Journal of Molecular Medicine

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Upregulation or downregulation of microRNAs (miRNAs) has been identified in human cervical cancer (CC). However, the character and function of miR-378 in CC remains unknown. In the present study, the authors demonstrated that miR-378 was upregulated in CC used the reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assay, and promoted cell proliferation by accelerating the progress of cell cycle and repressing cell apoptosis in CC cells. The predicted target genes of miR-378 were determined by enhanced green fluorescent protein (EGFP) reporter assays, RT-qPCR assay and western blot analysis. miR-378 suppressed the expression of suppression of tumorigenicity 7-like (ST7L) by targeting the 3′-untranslated region (3′-UTR) of ST7L mRNA in HeLa and SiHa cells. ST7L was downregulated in CC using the RT-qPCR assay, and the malignant phenotype of HeLa and SiHa cells were inhibited by ST7L overexpression. In addition, miR-378 activated the Wnt/β-catenin pathway by targeting ST7L in CC cells. In short, miR-378 functions as an onco-miRNA by directly downregulating ST7L mRNA and protein level in HeLa and SiHa cells, and serves important roles in the malignancy of CC.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer

Yang

Wang

et al. 2017

International Journal of Molecular Medicine

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“…For example, miR-23a accelerates autophagy and increases survival and migration of breast cancer cells by targeting XIAP (27). A previous study concluded that miR-23a up-regulates IKK alpha expression while down-regulating the expression of ST7L expression, ultimately enhancing the malignant phenotypes of epithelial ovarian cancer cells (28). The apoptosis of GC cells can be inhibited by miR-23a by down-regulating PPP2R5E (29).…”

Section: Discussionmentioning

confidence: 99%

Gastric Cancer Cell-Derived Exosomal microRNA-23a Promotes Angiogenesis by Targeting PTEN

Liu

et al. 2020

Front. Oncol.

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Hypoxia-exposed lung cancer-released exosomal microRNA-23a (miR-23a) has been shown to enhance angiogenesis as well as vascular permeability, contributing to the close correlation between exosomal miR-23a and tumorigenesis. The current study aimed to investigate whether gastric cancer (GC) cell-derived exosomal miR-23a could induce angiogenesis and to elucidate the potential mechanisms associated with the process. Differentially expressed miRNAs in GC were initially screened from the Gene Expression Omnibus database. Target genes were selected following miRNA-mRNA prediction and subsequently verified by dual luciferase reporter assay. RT-qPCR was conducted to detect miR-23a and PTEN expression in GC tissues, cells and exosomes. Human umbilical venous endothelial cells (HUVECs) were co-cultured with GC cell-derived exosomes to assess the angiogenesis mediated by exosomes in vitro. Additionally, PTEN was overexpressed in HUVECs to analyze the mechanism by which miR-23a regulates angiogenesis. miR-23a was highly expressed in GC tissues and cells and GC cell-derived exosomes. Angiogenesis was promoted by the co-culture of HUVECs and GC cells-derived exosomes, as evidenced by the increased expression of VEGF but decreased expression of TSP-1. PTEN was targeted by miR-23a and was lowly expressed in GC tissues. In a co-culture system, miR-23a carried by GC cells-derived exosomes promoted angiogenesis via the repression of PTEN. Collectively, GC cell-derived exosomal miR-23a could promote angiogenesis and provide blood supply for growth of GC cells. This study contributes to advancement of miRNA-targeted therapeutics.

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“…An example of miRNA that acting oncogene is miR‐23 that targets IKKa (IkA kinase, catalytic subunit of NF‐kB) and STL7 (Suppression of tumorigenicity 7 like, similarity to the ST7 tumor‐suppressor gene) , thus contributing to the malignancy of epithelial ovarian cancer (EOC) cells. The proliferation, migration, and invasion of EOC cells are increased by IKKa and inhibited by STL7 .…”

Section: Introductionmentioning

confidence: 98%

miRNAs in nutrition, obesity, and cancer: The biology of miRNAs in metabolic disorders and its relationship with cancer development

Martínez-Jiménez

Méndez-Mancilla

Portales-Pérez

2017

Molecular Nutrition Food Res

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Scope:The scope of this review is to explain how metabolic disorders originated by a deficient nutrition can develop into a neoplastic process by the alteration of epigenetic mechanisms like miRNAs. Obesity is a proinflammatory state with a wide impact on health around the world that is associated with neoplastic diseases. Epigenetic mechanisms have a central role in the obesogenic environment, which participates on the development of comorbidities such as cancer. Methods and results:We made an exhaustive review of the most recent reports about metabolic disorders with nutrition and their relationship with miRNAs, and their risk of developing into oncogenic processes. MicroRNAs (miRNAs) act as one of the major epigenetic mechanisms that can affect the metabolic reprogramming of cellular metabolism that plays an important role in the oncogenic process. There is evidence that some foods may contribute to diminishing the risk of cancer as well as epidemiological studies that support the notion that diets high in animal protein and fat promote cancer risk. Therefore, diets high in fruit and vegetables reduce the risk of cancer. One of the principal explanations is that these foods contain bioactive compounds that increase the efficacy of epigenetic mechanisms, which in turn decrease the risk of obesity and its comorbidities. Conclusion:In this review, we show how miRNAs are implicated in several signaling pathways as well as illustrating some bioactive compounds that impact inflammation and cancer development.

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RETRACTED ARTICLE: miR-23a promotes IKKα expression but suppresses ST7L expression to contribute to the malignancy of epithelial ovarian cancer cells

Cited by 53 publications

References 41 publications

miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer

miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer

Gastric Cancer Cell-Derived Exosomal microRNA-23a Promotes Angiogenesis by Targeting PTEN

miRNAs in nutrition, obesity, and cancer: The biology of miRNAs in metabolic disorders and its relationship with cancer development

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