RETRACTED ARTICLE: MicroRNA-320a acts as a tumor suppressor by targeting BCR/ABL oncogene in chronic myeloid leukemia

Zhu, Xiaoyan; Lin, Ziying; Du, Jing; Liu, Gang

doi:10.1038/srep12460

Cited by 61 publications

(46 citation statements)

References 36 publications

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“…In addition, it was found that hsa-miR-592 and hsa-miR-34c-3p were downregulated in lung cancer [Hu et al, 2016]. Evidence illustrates that miRNAs-320a is a new tumor suppressor which could decrease the migratory, invasive, proliferative, and apoptotic behaviors in chronic myeloid leukemia [Xishan et al, 2015]. However, few research were being published about hsa-miR-320 family; it was reported to be related with the acute lung injury induced by surgery necessitating cardio-pulmonary bypass [Yang et al, 2015].…”

Section: Discussionmentioning

confidence: 99%

Overexpression of Hsa‐miR‐320 Is Associated With Invasion and Metastasis of Ovarian Cancer

Wang

Yang

Xiang

et al. 2017

J of Cellular Biochemistry

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Ovarian cancer is one of the most common malignant tumor of female genital organs which ranks the third morbidity. We aimed to provide a better understanding of the mechanism of invasion and metastasis of ovarian cancer. The ovarian cancer samples were downloaded from GEO. Then clustering was performed to classify the stage of miRNAs based on the difference of prognosis and metastasis. Furthermore, the miRNAs model was build and the survival analysis processes was performed to observe the influence on prognosis, invasion and metastasis. At last, miRNAs co-expression network was built to explore the core miRNAs and the risk classification model was built to perform the risk assessment based on these core miRNAs. A total of 17 significantly differential expressed miRNAs were obtained. Functional enrichment of 1,488 target genes, pathways like cell cycle, focal adhesion, and pathways in cancer, which are closely related to the proliferation and metastasis of cancer cells were highly enriched, this indicate that these miRNAs are related to the proliferation and metastasis of cancer cells. The co-expressed network shows that the high expression of hsa-miR-320 indicated negative prognosis and high risk of metastasis. In conclusion, the expression level of hsa-miR-320 is highly related to the migration and invasion of cancer. The high expression of hsa-miR-320 directly indicated negative prognosis and high risk of metastasis. These findings reveal that hsa-miR-320 may serve as an important therapeutic target in ovarian cancer therapy. J. Cell. Biochem. 118: 3654-3661, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Overexpression of Hsa‐miR‐320 Is Associated With Invasion and Metastasis of Ovarian Cancer

Wang

Yang

Xiang

et al. 2017

J of Cellular Biochemistry

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“…As aforementioned, miRNA-320a has many targets. It can suppress the gene expression of IGF-1R, β-catenin, bCl/Abl and ArPP-19, among others (13,29,31,35), acting as a tumor suppressor in these cancer types. Thus, miRNA-320a is significantly downregulated in gliomas and in other malignant tumor types, and miRNA-320a overexpression could suppress tumor development in vivo and in vitro, potentially improving the prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…5A and B). In addition, miRNA-320a has been demonstrated to suppress the proliferation of K-562 chronic myelogenous leukemia, ln-229 glioblastoma and U2OS osteosarcoma cells (29,31,34). The results of these prior studies have each demonstrated that miRNA-320a could function as a tumor suppressor, and regulate progression and motility in glioma cells, as well as in other types of cancer.…”

Section: Upregulation Mirna-320a Inhibits Cell Invasion and Migrationmentioning

confidence: 99%

miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4

et al. 2018

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Glioma is the most aggressive and malignant type of primary intracranial tumor. In recent decades, despite the rapid development of modern surgery and therapeutic strategies available for brain tumors, the prognosis of glioma remains poor and the median survival time is <15 months. In this study, we found that the levels of miRNA-320a were significantly decreased in patients with glioma, and that elevated miRNA-320a expression was associated with a better prognosis. In addition, aquaporin 4 (AQP4) was identified as a direct target of miRNA-320a. Overexpression of miRNA-320a led to the inhibition of cell invasion and migration via targeting of AQP4. Therefore, our results suggested that miRNA-320a could suppress the aggressive capacity of tumors by targeting AQP4, and that miRNA-320a could serve as a new effective therapeutic target for glioma surgical and therapeutic strategies.

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“…Additionally, miR-320a has been observed to be an independent prognostic factor where decreased miR-320a expression is correlated with lower survival in invasive breast cancer. [32] The anti-proliferative and tumor-suppressing effects of miR-320a have also been recorded in lung cancer [33], prostate cancer [34], gastric cancer [35], leukemia [36, 37], and nasopharyngeal carcinoma [38]. …”

Section: Discussionmentioning

confidence: 99%

Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas

et al. 2016

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Breast cancer is the second-most common cancer and second-leading cause of cancer mortality in American women. The dysregulation of microRNAs (miRNAs) plays a key role in almost all cancers, including breast cancer. We comprehensively analyzed miRNA expression, global gene expression, and patient survival from the Cancer Genomes Atlas (TCGA) to identify clinically relevant miRNAs and their potential gene targets in breast tumors. In our analysis, we found that increased expression of 12 mature miRNAs—hsa-miR-320a, hsa-miR-361-5p, hsa-miR-103a-3p, hsa-miR-21-5p, hsa-miR-374b-5p, hsa-miR-140-3p, hsa-miR-25-3p, hsa-miR-651-5p, hsa-miR-200c-3p, hsa-miR-30a-5p, hsa-miR-30c-5p, and hsa-let-7i-5p —each predicted improved breast cancer survival. Of the 12 miRNAs, miR-320a, miR-361-5p, miR-21-5p, miR-103a-3p were selected for further analysis. By correlating global gene expression with miRNA expression and then employing miRNA target prediction analysis, we suggest that the four miRNAs may exert protective phenotypes by targeting breast oncogenes that contribute to patient survival. We propose that miR-320a targets the survival-associated genes RAD51, RRP1B, and TDG; miR-361-5p targets ARCN1; and miR-21-5p targets MSH2, RMND5A, STAG2, and UBE2D3. The results of our stringent bioinformatics approach for identifying clinically relevant miRNAs and their targets indicate that miR-320a, miR-361-5p, and miR-21-5p may contribute to breast cancer survival.

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RETRACTED ARTICLE: MicroRNA-320a acts as a tumor suppressor by targeting BCR/ABL oncogene in chronic myeloid leukemia

Cited by 61 publications

References 36 publications

Overexpression of Hsa‐miR‐320 Is Associated With Invasion and Metastasis of Ovarian Cancer

Overexpression of Hsa‐miR‐320 Is Associated With Invasion and Metastasis of Ovarian Cancer

miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4

Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas

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