RETRACTED ARTICLE: MicroRNA-205-5p inhibits skin cancer cell proliferation and increase drug sensitivity by targeting TNFAIP8

Abstract

Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a member of the TIPE/TNFAIP8 family which regulates tumor growth and survival. Our goal is to delineate the detailed oncogenic role of TNFAIP8 in skin cancer development and progression. Here we demonstrated that higher expression of TNFAIP8 is associated with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma development in patient tissues. Induction of TNFAIP8 expression by TNFα or by ectopic expression of TNFAIP8 in SCC or melanoma cell lines resulted in increased cell growth/proliferation. Conversely, silencing of TNFAIP8 decreased cell survival/cell migration in skin cancer cells. We also showed that miR-205-5p targets the 3′UTR of TNFAIP8 and inhibits TNFAIP8 expression. Moreover, miR-205-5p downregulates TNFAIP8 mediated cellular autophagy, increased sensitivity towards the B-RAFV600E mutant kinase inhibitor vemurafenib, and induced cell apoptosis in melanoma cells. Collectively our data indicate that miR-205-5p acts as a tumor suppressor in skin cancer by targeting TNFAIP8.

miRNA signatures underlie chemoresistance in the gemcitabine-resistant pancreatic ductal adenocarcinoma cell line MIA PaCa-2 GR

“…MiR-205-5p has been linked to cell proliferation and heightened drug responsiveness in basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. However, unlike in our investigation, where its influence is anticipated to stem from interactions with the multidrug resistance-associated protein family, miR-205-5p′s suppressive impact in skin cancer is attributed to its targeting of members within the tumor necrosis factor-α family ( Ge et al, 2021 ).…”

Novel lncRNA SNHG16 Promotes the Growth and Metastasis of Malignant Melanoma by Regulating miR-205-5p/PAK2 Axis

“… 33 Recent research has shown that miR-205-5p increases sensitivity to vemurafenib and induces cell apoptosis in melanoma by down-regulating TNFAIP8. 34 We further proved that miR-205-5p plays an anti-cancer role in melanoma. PAK2 is the target gene of miR-205-5p, and SNHG16 can directly bind to miR-205-5p.…”

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“…MiR-205-5p has been linked to cell proliferation and heightened drug responsiveness in basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. However, unlike in our investigation, where its influence is anticipated to stem from interactions with the multidrug resistance-associated protein family, miR-205-5p′s suppressive impact in skin cancer is attributed to its targeting of members within the tumor necrosis factor-α family (Ge et al, 2021).…”