RETRACTED ARTICLE: Long non-coding RNA SATB2-AS1 inhibits microRNA-155-3p to suppress breast cancer cell growth by promoting breast cancer metastasis suppressor 1-like

Abstract

Background Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play vital roles in human cancers. Nevertheless, the effects of lncRNAs and miRNAs on breast cancer (BC) remain to be further investigated. This study was designed to testify the roles of lncRNA antisense transcript of SATB2 protein (SATB2-AS1) and microRNA-155-3p (miR-155-3p) in BC progression. Methods Levels of SATB2-AS1, miR-155-3p and breast cancer metastasis suppressor 1-like (BRMS1L) in BC were determined. The prognostic role of SATB2-AS1 in BC patients was assessed. The screened cells were respectively introduced with altered SATB2-AS1 or miR-155-3p to figure out their roles in malignant phenotypes of BC cells. The effect of varied SATB2-AS1 and miR-155-3p on BC cells in vivo was observed. Dual luciferase reporter gene assay and RNA-pull down assay were implemented to detect the targeting relationship of SATB2-AS1, miR-155-3p, and BRMS1L. Results SATB2-AS1 and BRMS1L were decreased while miR-155-3p was increased in BC cells and tissues. Patients with lower SATB2-AS1 expression had poor prognosis. Elevated SATB2-AS1 and inhibited miR-155-3p were able to restrain malignant behaviors of BC cells in vitro, as well as decelerate tumor growth in vivo. Oppositely, inhibited SATB2-AS1 and amplified miR-155-3p had converse effects on BC cell growth. MiR-155-3p mimic abrogated the impact of overexpressed SATB2-AS1. SATB2-AS1 could sponge miR-155-3p, and BRMS1L was the target gene of miR-155-3p. Conclusion Elevated SATB2-AS1 and inhibited miR-155-3p could suppress the malignant phenotypes of BC cells, thereby restricting the development of BC.

Long Non-Coding RNAs in Oral Submucous Fibrosis: Their Functional Mechanisms and Recent Research Progress

“… 45 The lncRNAs in cytoplasm can bind directly to miR molecules, prevent them from binding to target genes, thereby upregulating expression of target genes. 46 lncRNAs can be used as “central platforms” to enable different macromolecular complexes to be assembled, thereby promoting information fusion and integration between different signaling pathways. 47 , 48 In addition, lncRNA can be used as secondary activators or enhancers for activation of target genes.…”

Retraction Note to: Long non-coding RNA SATB2-AS1 inhibits microRNA-155-3p to suppress breast cancer cell growth by promoting breast cancer metastasis suppressor 1-like

“…The Editors-in-Chief have retracted this article [ 1 ]. Concerns were raised with a number of figures, specifically: Fig.…”

LncRNA SATB2-AS1 overexpression represses the development of hepatocellular carcinoma through regulating the miR-3678-3p/GRIM-19 axis

“…Previous reports have illustrated that SATB2-AS1 is a critical regulator in some cancers. For example, some studies have confirmed that lncRNA SATB2-AS1 inhibits the growth of breast cancer cells by inhibiting miR-155-3p [ 9 ]. Xu M et al also illustrated that lncRNA SATB2-AS1 abated colorectal cancer (CRC) metastasis and affected the microenvironment of tumor immune cells by regulating SATB2 [ 10 ].…”