RETRACTED ARTICLE: Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells

Farooq, Muhammad Umar; Novosad, V.; Rozhkova, Elena A.; Wali, Hussain; Ali, Asghar; Fateh, Ahmed Ameen; Neogi, Purnima B.; Neogi, Arup; Wang, Zhiming

doi:10.1038/s41598-018-21331-y

Cited by 210 publications

(95 citation statements)

References 60 publications

(65 reference statements)

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“…A PEG coating can also be added to these nanoparticles to make them stealth and increase their blood half-life. They are used in preclinical investigations and clinical trials as drug delivery carriers [61], in photodynamic therapy for the treatment of cancer or imaging purposes [62]. Iron oxide nanoparticles can display ferromagnetic or superparamagnetic (preferred in the medical field) properties.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Nanocarriers as Magic Bullets in the Treatment of Leukemia

et al. 2020

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Leukemia is a type of hematopoietic stem/progenitor cell malignancy characterized by the accumulation of immature cells in the blood and bone marrow. Treatment strategies mainly rely on the administration of chemotherapeutic agents, which, unfortunately, are known for their high toxicity and side effects. The concept of targeted therapy as magic bullet was introduced by Paul Erlich about 100 years ago, to inspire new therapies able to tackle the disadvantages of chemotherapeutic agents. Currently, nanoparticles are considered viable options in the treatment of different types of cancer, including leukemia. The main advantages associated with the use of these nanocarriers summarized as follows: i) they may be designed to target leukemic cells selectively; ii) they invariably enhance bioavailability and blood circulation half-life; iii) their mode of action is expected to reduce side effects. FDA approval of many nanocarriers for treatment of relapsed or refractory leukemia and the desired results extend their application in clinics. In the present review, different types of nanocarriers, their capability in targeting leukemic cells, and the latest preclinical and clinical data are discussed.

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Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Nanocarriers as Magic Bullets in the Treatment of Leukemia

et al. 2020

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“…Global progress in nanotechnology has led to notable developments in nanomedicine, including new diagnostic systems, drug delivery methods, and a variety of disease treatments. [1][2][3][4][5][6] One such advancement is represented by gold nanoparticles, which have a large surface-to-size ratio and are highly reactive. 7,8 These properties allow gold nanoparticle functionalization with synthetic molecules or biomolecules (eg, antibodies, polymers, drugs, DNA, RNA, and peptides), in addition to facilitating biological barrier permeation and, consequently, access to different sites of interest.…”

Section: Introductionmentioning

confidence: 99%

<p>Improving Cell Penetration of Gold Nanorods by Using an Amphipathic Arginine Rich Peptide</p>

Riveros

Eggeling

Riquelme

et al. 2020

IJN

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Introduction: Gold nanorods are highly reactive, have a large surface-to-volume ratio, and can be functionalized with biomolecules. Gold nanorods can absorb infrared electromagnetic radiation, which is subsequently dispersed as local heat. Gold nanoparticles can be used as powerful tools for the diagnosis and therapy of different diseases. To improve the biological barrier permeation of nanoparticles with low cytotoxicity, in this study, we conjugated gold nanorods with cell-penetrating peptides (oligoarginines) and with the amphipathic peptide CLPFFD. Methods: We studied the interaction of the functionalized gold nanorods with biological membrane models (liposomes) by dynamic light scattering, transmission electron microscopy and the Langmuir balance. Furthermore, we evaluated the effects on cell viability and permeability with an MTS assay and TEM. Results and Discussion: The interaction study by DLS, the Langmuir balance and cryo-TEM support that GNR-Arg 7 CLPFFD enhances the interactions between GNRs and biological membranes. In addition, cells treated with GNR-Arg 7 CLPFFD internalized 80% more nanoparticles than cells treated with GNR alone and did not induce cell damage. Conclusion: Our results indicate that incorporation of an amphipathic sequence into oligoarginines for the functionalization of gold nanorods enhances biological membrane nanoparticle interactions and nanoparticle cell permeability with respect to nanorods functionalized with oligoarginine. Overall, functionalized gold nanorods with amphipathic arginine rich peptides might be candidates for improving drug delivery by facilitating biological barrier permeation.

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“…Their surface can be covalently -modi ed and they are resistant to oxidation [2]. All these properties enable the use of AuNPs to deliver different kinds of therapeutic agents [3]. Furthermore, AuNPs have speci c optical properties and can be easily detected and imaged.…”

Section: Introductionmentioning

confidence: 99%

Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells

Dey¹,

Gonon

Pécheur

et al. 2020

Preprint

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Background:Gold nanoparticles (AuNPs) have demonstrated outstanding performance in various biomedical applications, but their effects on the immune system remain ill-defined. We studied the impact of AuNPs on antigen-presenting cells (APCs) because of their phagocytic capacity that allows the accumulation of exogenous materials. As models, we used primary macrophages (M) and dendritic cells (DCs) originating from the bone marrow and tested the modulation of their functions, including phagocytosis, cell activation, production of cytokines and mediators and metabolic activity.Results: The AuNPs by themselves displayed no significant effect on M and DCs functions. However, when exposed to AuNPs, M and DCs responded differently to lipopolysaccharide (LPS) or Interleukin- 4(IL-4) stimulations. We showed AuNPs altered cytokine and reactive oxygen species (ROS) productions differently in M and DCs, whereas nitric oxide (NO) production by both cells remained unaffected. The metabolic profile underpins all functions of the immune cells and their polarisation. The analysis of the metabolic activity revealed that AuNPs significantly altered mitochondrial respiration and glycolysis of M, while only little effect was seen on DCs. Furthermore, we showed that T cell responses increased when antigen was presented by AuNPs-exposed DCs, leading to stronger Th1, Th2, and Th17 responses. Conclusions: Our data provide new insights into the complexity of the effects of AuNPs on the immune system. Although AuNPs may be considered on the whole to be devoid of direct significant effect, they may induce discrete modifications on some functions that can differ among the immune cells.

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RETRACTED ARTICLE: Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells

Cited by 210 publications

References 60 publications

Nanocarriers as Magic Bullets in the Treatment of Leukemia

Nanocarriers as Magic Bullets in the Treatment of Leukemia

<p>Improving Cell Penetration of Gold Nanorods by Using an Amphipathic Arginine Rich Peptide</p>

Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells

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