RETRACTED ARTICLE: Genetic analysis and forensic evaluation of 47 autosomal InDel markers in four different Chinese populations

Pan, Xiyong; Liu, Changhui; Du, Weian; Chen, Ling; Xia, Han; Yang, Xingyi; Liu, Chao

doi:10.1007/s00414-019-02059-4

Cited by 8 publications

(5 citation statements)

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“…Springer Nature, for instance, said in December 2019 that it would investigate papers of concern on vulnerable groups along these lines, and that it had updated its guidance to editors and authors about the need to gain explicit and informed consent in studies that involve clinical, biomedical or biometric data from people. This year, the publisher retracted two papers on DNA sequencing 8,9 because the authors conceded that they hadn't asked Uyghur people for their consent, and it has placed expressions of concern on 28 others.…”

Section: Vulnerable Populationsmentioning

confidence: 99%

The ethical questions that haunt facial-recognition research

Noorden¹

2020

Nature

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Section: Vulnerable Populationsmentioning

confidence: 99%

The ethical questions that haunt facial-recognition research

Noorden¹

2020

Nature

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“…Notably, the new InDel-based multiplexes include a large number of overlapping autosomal markers (n = 45) from the 1,000 Genomes Project, more than the DIPplex Kit (n = 17) (Genomes Project et al, 2010Project et al, , 2012Project et al, , 2015. Several validation studies have demonstrated its powerful ability and potential in forensic investigations and have shown high informativity among populations (Pan et al, 2019;Wang, Wang, He, Zhu, & Hou, 2019). Han Chinese, accounting for approximately 20% of the total population worldwide, is the most widely distributed ethnic group, with a population size of nearly 1.4 billion (Xu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Forensic features and genetic background exploration of a new 47‐autosomal InDel panel in five representative Han populations residing in Northern China

Song

Lang

et al. 2020

Molec Gen & Gen Med

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BackgroundInsertion/deletion (InDel) analysis plays an indispensable role in human identification, population genetics, and biogeographic research. Profiles of individuals in forensic applications worldwide based on a set of autosomal InDel loci (A‐InDels) in human genomes have been widely used over the past few years.MethodsThe new AGCU InDel 50 Kit contains 47 well‐chosen A‐InDels, ensuring high discriminatory power, and the 2 Y chromosome InDel loci (Y‐InDels) are used for sex determination in case of allele dropout at Amelogenin. In this study, five Northern Han populations residing in different geographic areas of China were recruited and genotyped using the assay.ResultsAfter Bonferroni correction, all 47 A‐InDels were in accordance with the lack of significant departures of Hardy–Weinberg equilibrium in all loci and investigated groups. The combined probability of discrimination and the probability of exclusion in the Han population range from 1–3.2240 × 10–19 to 1–1.3030 × 10–19 and 0.9997, respectively. A comprehensive population genetic relationship investigation between Han Chinese and 26 worldwide populations based on allele frequency correlation was carried out. Our results revealed no significant genetic differentiation in Chinese Han groups. Hierarchical clustering, phylogenetic relationship reconstructions, multidimensional scaling, principal component analysis, and structure analysis were performed, and the results indicated that, genetically, Han populations are closely related to East Asians.ConclusionOverall, this novel 47 A‐InDel assay is a valuable tool that could potentially be used for forensic identification and parentage tests.

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“…The recent announcement by Springer Nature of the retraction of a 2019 paper [2] on Y-chromosome profiling of ethnic minorities in China and of another on InDel profiling [3], and the placing under scrutiny of more than two dozen others for similar concerns, is an important step in the right direction. However, it still appears that almost half of over a thousand articles describing forensic genetics studies in Chinese populations have at least one co-author from the Chinese police, judiciary or related institutions.…”

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confidence: 99%