RETRACTED ARTICLE: Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA

Kang, Min; Ren, Mulan; Yan, Li; Fu, Yuqiong; Deng, Minmin; Li, Changping

doi:10.1186/s13046-018-0845-9

Cited by 164 publications

(152 citation statements)

References 40 publications

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“…It could be packaged into exosomes and transferred to sensitive cells, thus spreading sunitinib resistance. A similar study conducted by Kang et al also confirmed the role of lncRNA in drug resistance dissemination. In that study, exosome‐mediated transfer of lncRNA PART1 was demonstrated to induce gefitinib resistance in esophageal squamous cell carcinoma.…”

Section: Exosomes Functions In Tumor Pathogenesissupporting

confidence: 71%

Exosomes: The Indispensable Messenger in Tumor Pathogenesis and the Rising Star in Antitumor Applications

Wang

Wei

et al. 2019

Adv. Biosys.

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understanding of the underlying interaction mechanisms between tumor cells and the TME, as well as derivative tumor treatment strategies, is of great significance for oncology and diagnostic development.Exosomes represent a kind of nanosized (30-150 nm) lipid bilayer membrane vesicles that are naturally secreted by almost all types of cells and exist widely in various body fluids, such as plasma, [4] saliva, [5] perspiration, urine, [6] latex, cerebrospinal fluid, nasal mucus, and ascites. After their discovery in 1983, exosomes were widely considered as useless "cellular waste" for a long time. [7] In 1996, Raposo et. al. [8] demonstrated that exosomes derived from human and murine B lymphocytes could transfer antigen and induce antigen-specific T cell responses, which discovery changed the "cellular waste concept" of exosomes. Renewed interest in exosomes followed recent reports demonstrating that exosomes contribute to various aspects of cellular homeostasis, physiology and pathobiology. [9] Intercellular communication is considered as one of the most fascinating roles of exosomes. [10] As the intercellular vehicles to transport message, exosomes inherit various molecular information (including proteins, nucleic acids, lipids) from the origin cell and reflect the phenotypic state. Moreover, these biological entities subsequently affect physiological and pathological processes such as inflammation, immune surveillance, tumorigenesis. [11] As important parts of the tumor microenvironment (TME), exosomes have been widely investigated in past decades and demonstrated to possess specialized functions in tumor initiation, progression, metastasis, angiogenesis, and drug resistance. [12,13] Moreover, the specific molecular signature inherited from the origin tumor cell endow tumor-derived exosomes with the capacity to predict tumor progression and prognosis. [14,15] On the other hand, immune cell-derived exosomes, such as DC-derived exosomes, NK-derived exosomes and M1 macrophage-derived exosomes, play vital roles in activating antitumor immune response, which properties endow these exosomes with promising potential in acting as tumor therapeutic vaccine. In addition, the vesicular biocompatibility, nanometer dimension size and biochemical properties make sophisticated exosomes a novel promising therapeutic nanoplatform in cancer. [16] In this review, efforts are made to provide a comprehensive and critical overview about recent advances in exosome-related research field, ranging from their biogenesis, secretion, isolation and biological function in tumor pathogenesis to their extensive antitumor applications.As natural secreted nanovesicles through the endolysosomal pathway, exosomes have attracted increasing attention over the past decades. An overwhelming number of studies have provided evidence for the intriguing roles that exosomes play in intercellular communication. They are widely involved in the transmission of biomolecule cargos between original cells and neighboring/distant cells in normal physiologica...

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Section: Exosomes Functions In Tumor Pathogenesissupporting

confidence: 71%

Exosomes: The Indispensable Messenger in Tumor Pathogenesis and the Rising Star in Antitumor Applications

Wang

Wei

et al. 2019

Adv. Biosys.

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“…RNA pull down confirmed the binding ability between PART1 and miR‐635. Except for miR‐129 in ESCC, miR‐133a, miR‐135b, miR‐196b, and miR‐193b in oral squamous cell carcinoma, to the best of our knowledge, we first found that miR‐635 was a new target miRNA for PART1. Moreover, in the present study, we demonstrated that PART1 promoted cell proliferation, migration, and invasion of NSCLC, while knockdown of PART1 performed the opposite effects on NSCLC progression.Other lncRNAs, such as MALAT1, HOTAIR, and UCA1, that were highly expressed in NSCLC, also promoted the progression and the inhibition of these lncRNAs suppressed the progression.…”

Section: Discussionmentioning

confidence: 82%

“…Otherwise, PART1 promotes tumor progression of colorectal cancer via sponging miR‐143 and regulating DNA‐methyltransferase 3A . In esophageal squamous cell carcinoma (ESCC), PART1 is upregulated and involved in poor response to gefitinib treatment, thus functioning as a novel therapeutic target for the disease . Moreover, previous study has shown that PART1 is upregulated in NSCLC specimens with poor prognosis and is related to tumor recurrence of NSCLC .…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA PART1 promotes progression of non‐small cell lung cancer cells via JAK‐STAT signaling pathway

Zhu

Wang

et al. 2019

Cancer Medicine

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Non‐small cell lung cancer (NSCLC), the major type of lung cancer, becomes the greatest threat to the life of people. Growing evidence shows prostate androgen‐regulated transcript 1 (PART1) is considered as effective markers for prostate cancer, and has been shown to be associated with poor prognosis of NSCLC. However, the tumorigenic mechanism of PART1 in NSCLC remains to be investigated. In this study, we found that the expression of PART1 was robustly induced in NSCLC tissues and cell lines. Functional studies established that overexpression of PART1 could promote NSCLC cell proliferation, migration, and invasion, while interference of PART1 inhibited NSCLC progression. Our results also identified miR‐635 as a novel target of PART1, whose expression was inhibited by PART1 in NSCLC cell lines. Moreover, gain‐ and loss‐of‐function studies revealed that PART1 could sponge miR‐635 and increase the expression of Janus kinase (JAK) and signal transducer and activator of transcription proteins (STATs). Finally, we deciphered the molecular mechanism by which PART1 contributed to promotion of NSCLC cell progression via phosphorylation and activation of JAK‐STAT signaling pathway. The animal experiment further confirmed that interference of NSCLC could suppress in vivo tumorigenic ability of NSCLC with favorable pharmacological activity via inactivation of JAK‐STAT signaling pathway. In conclusion, our findings clarified the biologic significance of PART1/miR‐635/JAK‐STAT axis in NSCLC progression and provided novel evidence that PART1 may be a new potential therapeutic target for the treatment of NSCLC.

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“…Exosomal PART1 could be used in the clinic as a treatment selection biomarker. High PART1 expression in serum exosomes indicates gefitinib resistance [92] . Another exosomal lncRNA, H19, has also been reported to promote gefitinib resistance.…”

Section: Targeted Therapymentioning

confidence: 99%

The role of exosomal long non-coding RNAs in cancer drug resistance

Santos

Dragomir

2019

CDR

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One of the major challenges in oncology is drug resistance, which triggers relapse and shortens patients' survival. In order to promote drug desensitization, cancer cells require the establishment of an ideal tumor microenvironment that accomplishes specific conditions. To achieve this objective, cellular communication is a key factor. Classically, cells were believed to restrictively communicate by ligand-receptor binding, physical cell-to-cell interactions and synapses. Nevertheless, the crosstalk between tumor cells and stroma cells has also been recently reported to be mediated through exosomes, the smallest extracellular vesicles, which transport a plethora of functionally active molecules, such as: proteins, lipids, messenger RNA, DNA, microRNA or long non-coding RNA (lncRNAs). LncRNAs are RNA molecules greater than 200 base pairs that are deregulated in cancer and other diseases. Exosomal lncRNAs are highly stable and can be found in several body fluids, being considered potential biomarkers for tumor liquid biopsy. Exosomal lncRNAs promote angiogenesis, cell proliferation and drug resistance. The role of exosomal lncRNAs in drug resistance affects the main treatment strategies in oncology: chemotherapy, targeted therapy, hormone therapy and immunotherapy. Overall, knowing the molecular mechanisms by which exosomal lncRNA induce pharmacologic resistance could improve further drug development and identify drug resistance biomarkers.

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RETRACTED ARTICLE: Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA

Cited by 164 publications

References 40 publications

Exosomes: The Indispensable Messenger in Tumor Pathogenesis and the Rising Star in Antitumor Applications

Exosomes: The Indispensable Messenger in Tumor Pathogenesis and the Rising Star in Antitumor Applications

Long noncoding RNA PART1 promotes progression of non‐small cell lung cancer cells via JAK‐STAT signaling pathway

The role of exosomal long non-coding RNAs in cancer drug resistance

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