RETRACTED ARTICLE: Efficient chemosensitizing and antimetastatic combinations of a naturally occurring trans-ferulic acid with different chemotherapies on an in vitro hepatocellular carcinoma model

Abdel-Hamid, Nabil Mohie; ElNakeeb, Nadia A; El-Senduny, Fardous F.

doi:10.1007/s00210-023-02431-7

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2024

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“…However, it should be noted that the inhibitory effects of the combined doxorubicin-barakol on MMP-3 activity and cell migration were not investigated in this work and should be further studied. The previous study reported that doxorubicin inhibited hepatic cancer cell (HepG2) migration by suppressing MMP-3 expression, and the inhibition was synergized by co-treatment with a natural-derived compound, trans -ferulic acid [ 66 ]. From this evidence, it is hypothesized that barakol, as an MMP-3 inhibitor, may potentiate the anti-metastatic effect of doxorubicin similarly.…”

Section: Discussionmentioning

confidence: 99%