RETRACTED ARTICLE: CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p

Ding, Rong; Chen, Lu; Zhang, Betty; Fu, Kai; Zhao, Shuli; Tang, Weiwei; Cao, Hongxin

doi:10.1186/s12943-019-0958-6

Cited by 160 publications

(126 citation statements)

References 31 publications

(29 reference statements)

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“…Acting as a sponge of miR‐214‐5p, hsa_circ_0000993 may be used as a target for the treatment of GC . It has also been found that circPSMC3 acted as a sponge of miR‐296‐5p to regulate PTEN expression in GC …”

Section: Tumor‐suppressive Circrnas and Cancersmentioning

confidence: 99%

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

et al. 2019

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internal ribosome entry site; LARP4, La-related protein 4; LATS1, large tumor suppressor kinase 1; lncRNAs, long noncoding RNAs; MIBC, muscle invasive bladder cancer; miRNA, microRNA; ncRNAs, noncoding RNAs; NF1, neurofibromin 1; Notch1, notch homolog 1; NSCLC, non-small cell lung cancer; OS, overall survival; PCK1, phosphoenolpyruvate carboxykinase 1; PDAC, pancreatic ductal adenocarcinoma; RBP, RNA-binding protein; RCAN1, regulation of Down syndrome critical region gene 1; sncRNAs, short noncoding RNAs; TIMP3, metalloproteinase inhibitor 3; USP28, ubiquitin-specific peptidase 28; YBX1, Y box binding protein 1. AbstractCircular RNAs (circRNAs) have a covalently closed circular conformation and are structurally stable. Those circRNAs with tumor-suppressive properties play an important role in tumorigenesis and metastasis and thus may be used as therapeutic targets of cancers. Herein, we review the current understanding of the classification of circRNAs and summarize the functions and mechanisms of circRNAs that have tumor-suppressive roles in various cancers, including liver cancer (circARSP91, circ-ADAMTS13, circADAMTS14, circMTO1, hsa_circ_0079299, and circC3P1), bladder cancer (circFNDC3B, circITCH, circHIPK3, circRNA-3, cdrlas, and circLPAR1), gastric cancer (circLARP4, circYAP1, hsa_cric_0000096, hsa_circ_0000993, and circPSMC3), breast cancer (circ_000911, hsa_circ_0072309, and circASS1), lung cancer (hsa_ circ_0000977, circPTK2, circ_0001649, hsa_circ_100395, and circ_0006916), glioma (circ_0001946, circSHPRH, and circFBXW7), and colorectal cancer (circITGA7 and hsa_circ_0014717). Thanks to their structural stability, these tumor-suppressive cir-cRNAs may be used as potential and potent therapeutic targets. Moreover, we propose a new method for the classification of circRNAs. Based on whether they can be translated, circRNAs can be divided into noncoding circRNAs and coding circRNAs. K E Y W O R D Sbiogenesis, cancer, circular RNA, mechanism, therapeutic target | INTRODUC TI ONThose RNAs that do not encode proteins are called ncRNAs. 1 Regulatory ncRNAs are divided into lncRNAs and sncRNAs. LncRNAs can be linear or circular. 2 Circular RNAs were first discovered in 1976. 3 Since then, a variety of circRNAs have been discovered. 4,5 CircRNAs are more resistant to exonuclease and are more stable than other lncRNAs. 3,6 They exist in exosomes and plasma. 6,7 Li et al identified more than 1000 circRNAs in human serum exosomes. 6 Li et al found 343 differentially How to cite this article:

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Section: Tumor‐suppressive Circrnas and Cancersmentioning

confidence: 99%

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

et al. 2019

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“…For example, circAKT3 promotes PIK3R1 expression via miR-198 suppression in gastric cancer [42] . CircPSMC3 acts as a miR-296-5p sponge to promote the expression of phosphatase and tensin homolog [43] . In subsequent studies, we intend to use miR-203 as a starting point to identify circRNAs that can affect miR-203, so as to further explore the targets of pancreatic cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

MiR-203 inhibits the proliferation, invasion, and migration of pancreatic cancer cells by down-regulating fibroblast growth factor 2

Zhao

Chen

et al. 2020

Preprint

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Background: Aberrant fibroblast growth factor 2 (FGF2) expression is a major cause of poor prognosis in pancreatic cancer. MiR-203 is a newly discovered microRNA (miRNA) that can affect the biological behavior of tumors. This study investigated whether miR-203 can regulate FGF2 expression and its role in pancreatic cancer cell proliferation, apoptosis, invasion, and migration.Methods: MiR-203 expression in different cell lines was examined by qRT-PCR, followed by the establishment of knockdown and overexpression cell models. We used the CCK-8 assay to examine cell proliferation and the annexin V-APC/7-AAD doublestaining method to detect apoptosis. In addition, we used wound healing and transwell assays to investigate the effects of miR-203 on the migration and invasion of pancreatic cancer cells. The effects of miR-203 knockdown and overexpression on FGF2 mRNA expression were detected by qRT-PCR. We also overexpressed FGF2 and examined the effects of FGF2 overexpression on the proliferation, apoptosis, invasion, and migration of pancreatic cancer cells. The binding of miR-203 to FGF2 was assessed by a luciferase reporter assay. Results:We found that the miR-203 expression level was significantly down-regulated in pancreatic cancer cells compared to normal pancreatic cells. Functionally, the knockdown of miR-203 inhibited cell proliferation and increased apoptosis. Equally important, miR-203 reduced the migration and invasion of pancreatic cancer cells. In addition, we found that miR-203 overexpression inhibited FGF2 expression in pancreatic cancer cells by qRT-PCR. FGF2 overexpression significantly affected the proliferation, invasion, and metastasis of pancreatic cancer cells. Mechanistically, miR-203 base-paired with the FGF2 mRNA, resulting in the knockdown of the FGF2 mRNA and the down-regulation of the FGF2 protein. Conclusions:MiR-203 inhibits FGF2 expression, regulates the proliferation of pancreatic cancer cells, and inhibits the invasion and metastasis of pancreatic cancer cells.

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“…Increasing evidence indicated that circRNAs act as potential biomarkers in patients with GC. Upregulation of circ-DON-SON, circAKT3, and circDLST [8,11,13] or downregulation of KIAA1244, circPSMC3, and circFAT1(e2) [14][15][16] is regarded as independent prognostic factors of poor prognosis in patients with GC. Herein, we identified a novel circDUSP16, and it was resistant to RNase R and localized in the cytoplasm of GC cells.…”

Section: Discussionmentioning

confidence: 99%

“…For one thing, circAKT3, circNRIP1, and circDLST facilitate tumor growth and metastasis and enhance cisplatin resistance in GC cells [11][12][13]. For another thing, circPSMC3 and circFAT1(e2) inhibit the tumorigenesis and invasion of GC cells [15,16]. However, the functional role of circDUSP16 in GC remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…CircAKT3 and circDLST act as the sponges of miR-198/-502-5p to favor the tumorigenesis and cisplatin resistance in GC cells [11,13]. In addition, circ-KIAA1244 [14], circPSMC3 [15], and circFAT1(e2) [16] are downregulated in GC tissues and plasmas, and their decreased expression is related to tumor invasiveness and poor survival in GC patients [14][15][16]. These circRNAs may provide potential biomarkers for the treatment of GC.…”

Section: Introductionmentioning

confidence: 99%

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CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p

et al. 2019

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Background Circular RNAs (circRNAs) as a novel subgroup of non-coding RNAs act a critical role in the pathogenesis of gastric cancer (GC). However, the underlying mechanisms by which hsa_circ_0003855 (circDUSP16) contributes to GC are still undocumented. Materials The differentially expressed circRNAs were identified by GEO database. The association of circDUSP16 or miR-145-5p expression with clinicopathological features and prognosis in GC patients was analyzed by FISH and TCGA-seq data set. Loss-and gain-of-function experiments as well as a xenograft tumor model were performed to assess the role of circDUSP16 in GC cells. circDUSP16-specific binding with miR-145-5p was confirmed by bioinformatic analysis, luciferase reporter, and RNA immunoprecipitation assays. Results The expression levels of circDUSP16 were markedly increased in GC tissue samples and acted as an independent prognostic factor of poor survival in patients with GC. Knockdown of circDUSP16 repressed the cell viability, colony formation, and invasive potential in vitro and in vivo, but ectopic expression of circDUSP16 reversed these effects. Moreover, circDUSP16 possessed a co-localization with miR-145-5p in the cytoplasm, and acted as a sponge of miR-145-5p, which attenuated circDUSP16-induced tumor-promoting effects and IVNS1ABP expression in GC cells. MiR-145-5p had a negative correlation with circDUSP16 expression and its low expression was associated with poor survival in GC patients. Conclusions CircDUSP16 facilitates the tumorigenesis and invasion of GC cells by sponging miR-145-5p, and may provide a novel therapeutic target for GC.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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RETRACTED ARTICLE: CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p

Cited by 160 publications

References 31 publications

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

MiR-203 inhibits the proliferation, invasion, and migration of pancreatic cancer cells by down-regulating fibroblast growth factor 2

CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p

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