RETRACTED ARTICLE: Bimatoprost Imprinted Silicone Contact Lens to Treat Glaucoma

Yuan, Feng; Liu, Yanxia; Han, Shulan; Zhao, Qingsong; Liu, Nannan

doi:10.1208/s12249-020-1622-6

Cited by 33 publications

(23 citation statements)

References 50 publications

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“…Subsequent investigations into molecular imprinted contact lens drug delivery systems furthered the understanding of critical parameters, backbone monomers, functional monomers and crosslinker concentrations needed for systems designed for different ocular pharmaceuticals. Published examples included a wide variety of drugs, including anti-allergy [287,288], antibacterial [289][290][291][292], anti-inflammatory [293][294][295], anti-glaucoma [296,297] and dry eye [298,299], all of which demonstrated some substantial increase in drug loading and release times in vitro compared to non-imprinted materials.…”

Section: Molecular Imprintingmentioning

confidence: 99%

“…Several studies have monitored tear drug concentrations with molecular imprinting use in animal models and compared them to levels found with eye drops or drug soaked non-imprinted materials [297,300,301]. A biomimetic inspired molecular imprinted contact lens for the release of ketotifen demonstrated upwards of 72 h of release when tested in vitro and a mean residence time of approximately 12 h in the tear film of New Zealand white rabbits, with a peak in concentration seen within four hours [301].…”

Section: Molecular Imprintingmentioning

confidence: 99%

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BCLA CLEAR – Contact lens technologies of the future

Jones

Hui

Phan

et al. 2021

Contact Lens and Anterior Eye

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Contact lenses in the future will likely have functions other than correction of refractive error. Lenses designed to control the development of myopia are already commercially available. Contact lenses as drug delivery devices and powered through advancements in nanotechnology will open up further opportunities for unique uses of contact lenses.This review examines the use, or potential use, of contact lenses aside from their role to correct refractive error. Contact lenses can be used to detect systemic and ocular surface diseases, treat and manage various ocular conditions and as devices that can correct presbyopia, control the development of myopia or be used for augmented vision. There is also discussion of new developments in contact lens packaging and storage cases.The use of contact lenses as devices to detect systemic disease has mostly focussed on detecting changes to glucose levels in tears for monitoring diabetic control. Glucose can be detected using changes in colour, fluorescence or generation of electric signals by embedded sensors such as boronic acid, concanavalin A or glucose oxidase. Contact lenses that have gained regulatory approval can measure changes in intraocular pressure to monitor glaucoma by measuring small changes in corneal shape. Challenges include integrating sensors into contact lenses and detecting the signals generated. Various techniques are used to optimise uptake and release of the drugs to the ocular surface to treat diseases such as dry eye, glaucoma, infection and allergy. Contact lenses that either mechanically or electronically change their shape are being investigated for the management of presbyopia. Contact lenses that slow the development of myopia are based upon incorporating concentric rings of plus power, peripheral optical zone(s) with add power or non-monotonic variations in power. Various forms of these lenses have shown a reduction in myopia in clinical trials and are available in various markets.

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Section: Molecular Imprintingmentioning

confidence: 99%

Section: Molecular Imprintingmentioning

confidence: 99%

BCLA CLEAR – Contact lens technologies of the future

Jones

Hui

Phan

et al. 2021

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

show abstract

“…The drug is then re-loaded in the polymer by soaking and interacting with the memory sites. This process can lead to a higher drug loading and a slower release profile [81], and it was successfully applied to therapeutic CLs and IOLs [82][83][84][85][86][87][88]. The use of miscible combinations of drugs and monomers is generally preferable over non-miscible ones in order to avoid the use of solvents, since their presence could prevent the orientation of monomers around the drug molecules and result in a less effective imprinting [89].…”

Section: Molecular Imprintingmentioning

confidence: 99%

“…Molecular imprinted CLs were also successfully studied: uptake and release kinetics of timolol [82], bimatoprost [83], ethoxzolamide, and acetazolamide [84,85] were positively influenced by the presence of imprinted domains in the lens material, without significant affection of the CL properties. Timolol was released up to 90 h in vitro, due to the interactive sites between the drug and HEMA, carboxy-methyl chitosan, and acrylamide, which compose the CL material.…”

Section: Lenses For Ocular Diseases 41 Glaucomamentioning

confidence: 99%

Therapeutic Ophthalmic Lenses: A Review

2020

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An increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. In order to overcome these problems, the design of drug-eluting ophthalmic lenses constitutes a non-invasive and patient-friendly approach for the sustained drug delivery to the eye. Several examples of therapeutic contact lenses and intraocular lenses have been developed, by means of different strategies of drug loading, leading to promising results. This review aims to report the recent advances in the development of therapeutic ophthalmic lenses for the treatment and/or prophylaxis of eye pathologies (i.e., glaucoma, cataract, corneal diseases, or posterior segment diseases) and it gives an overview of the future perspectives and challenges in the field.

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“…In order to enhance hydrogel properties, it is possible to copolymerize HEMA with various monomers. [20][21][22][23][24][25][26][27] Conjunctivitis is expressed by redness of the eye, itching, the feeling of dry eye and eye irritation. Conjunctivitis is usually caused by eye infection, but also by allergy, exposure to certain chemicals, etc.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted soft contact lenses as chloramphenicol delivery systems

Koldžić¹,

Nikoletić²

2020

Tehnika

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Due to the fact that only a small part of the ophthalmic drugs, taken in traditional ways, reaches the affected area patients need to take large amounts of medication. This problem could be overcome by extending the duration of a drug's spent time on the eye surface. One of the most common eye infections is conjunctivitis, for which chloramphenicol is the most used medication. Because of their unique properties, hydrogels are used for contact lens production. The principal aim of this work is to develop a novel soft contact lenses material capable of sustained chloramphenicol delivery. The influence of different comonomers on hydrogels' characteristics was examined. Various hydrogels imprinted for chloramphenicol, based on poly(2-hydroxyethyl methacrylate), were synthetized. The sorption and releasing kinetics were studied at conditions simulating the human eye. It was proven that 2hydroxyethyl methacrylate copolymer with methacrylic acid was the most efficient for releasing chloramphenicol, following the zero-order kinetics during a 24-hour period. This suggests that synthetized hydrogels present a promising solution to the problem of sustained chloramphenicol delivery.

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RETRACTED ARTICLE: Bimatoprost Imprinted Silicone Contact Lens to Treat Glaucoma

Cited by 33 publications

References 50 publications

BCLA CLEAR – Contact lens technologies of the future

BCLA CLEAR – Contact lens technologies of the future

Therapeutic Ophthalmic Lenses: A Review

Molecularly imprinted soft contact lenses as chloramphenicol delivery systems

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