Retracted and Republished from: “Gut Microbiota Mediates the Therapeutic Effect of Monoclonal Anti-TLR4 Antibody on Acetaminophen-Induced Acute Liver Injury in Mice”

Sun, Xuewei; Cui, Qian; Ni, Juan; Liu, Xiaoguang; Zhu, Jin; Zhou, Tingting; Huang, Huaying; OuYang, Ke; Wu, Yuankui; Yang, Zhan

doi:10.1128/spectrum.04715-22

Cited by 1 publication

(1 citation statement)

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“…It is uniquely adapted to colonize the mucus layer and has a diverse enzyme repertoire to degrade and utilize mucin for growth 197 . It also liberates nutrients from mucin to foster the growth of butyrate producers and its production of acetate enhances butyrate production by syntropy 110,117,[198][199][200][201] . In part through its production of acetate, A. muciniphila, also stimulates mucin production and does so even better than Lactobacillus plantarum, one of the probiotic species previously shown to be protective against morphine dysbiosis and tolerance 202 .…”

Section: Discussionmentioning

confidence: 99%

Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic voluntary morphine

Sall,

Foxall,

Felth

et al. 2024

Preprint

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The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for dependence and addiction. Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut dysbiosis exacerbates tolerance, whereas probiotics ameliorate tolerance. Not all individuals develop tolerance which could be influenced by differences in microbiota, and yet no study has capitalized upon this natural variation to identify specific features linked to tolerance. We leveraged this natural variation in a murine model of voluntary oral morphine self-administration to elucidate the mechanisms by which microbiota influences tolerance. Although all mice shared similar and predictive morphine-driven microbiota changes that largely masked informative associations with variability in tolerance, our high-resolution temporal analyses revealed a divergence in the progression of dysbiosis that best explained differences in the development in tolerance. Mice that did not develop tolerance also maintained a higher abundance of taxa capable of producing the short-chain fatty acid (SCFA) butyrate, known to bolster intestinal barriers, suppress inflammation, and promote neuronal homeostasis. Furthermore, dietary butyrate supplementation significantly reduced the development of tolerance. These findings could inform immediate therapies to extend the analgesic efficacy of opioids.

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