[Retracted] Analysis of the Effect of DPL Combined with Clarithromycin in the Therapy and Improvement of Rosacea

Abstract

Rosacea is a chronic inflammatory skin disease with a high incidence, and it leads to negative emotions such as inferiority complex, increased psychological pressure, and a greatly reduced quality of life. In order to investigate the clinical efficacy of DPL combined with clarithromycin in the treatment and improvement of rosacea. 86 patients with rosacea were selected and randomly divided into the control group and study group according to the random number table method. The results show that the combination of DPL and clarithromycin in the treatment of rosacea patients can effectively improve the clinical symptoms of patients, improve the therapeutic effect, and the incidence of adverse reactions is low, which ensures that the patients have a good prognosis, which is worthy of clinical application.

Quality of life measurement in rosacea. Position statement of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

“…Azelaic acid gel either alone or in combination with other standard treatment for rosacea showed significant improvement in all four components of the RosaQoL over the course of treatment, regardless of the type of therapy prescribed 44 . Comparison of oral clarithromycin 250 mg, twice a day for 6 weeks with clarithromycin combined with pulsed dye laser showed significant quimp improvement in both groups but greater improvement in the group with combined treatment regimen 69 …”

“…From the 207 articles identified in the literature search, 139 were excluded based on the exclusion criteria, leaving 68 publications 20–87 for the further analysis.…”

“…Another generic HRQoL instrument EuroQoL (EQ)‐5D 55,67 and its modifications EQ‐5D‐3L 76 and EQ‐5D‐visual analogue scale 77 were also used to assess quimp in rosacea. The dermatology‐specific Dermatology Life Quality Index (DLQI) was used for quimp assessment in 45 studies on rosacea 20–23,25,28–30,32,34,35,37,40–42,46,48–57,60,62–69,72–74,77,78,80,82,83,86,87 . Data on the DLQI scores from included articles is given in Figure 1.…”

“…Before (Italia) 87 Lockdown mask users. After (Italia) 87 Before treatment (Israel) 54 Online survey (International) 39 Survey (Germany) 63 Survey (Germany) 52 Before treatment (Germany) 50 Online survey (Germany) 49 Treatment group (Germany) 21 Placebo group (Germany) 21 Online survey (Denmark) 35 Outpatients (China) 74 Before treatment in study group (China) 69 Before treatment in control group (China) 69 Outpatients (China) 68 Rosacea patients with anxiety (China) 66 Rosacea patients with depression (China) 66 Rosacea patients without anxiety (China) 66 Rosacea patients without depression (China) 66 Online survey (China) 60 Outpatients and online survey (China) 53 Before treatment (China) 51 Before treatment (China) 20 Median DLQI…”

“…44 Comparison of oral clarithromycin 250 mg, twice a day for 6 weeks with clarithromycin combined with pulsed dye laser showed significant quimp improvement in both groups but greater improvement in the group with combined treatment regimen. 69 In several open-label studies a significant improvement of QoL was reported after use of pulsed dye laser alone 62,65,78,79 and in combination with 1.064 nm neodymium-doped yttrium aluminium garnet laser 22 and non-ablative fractional 1440-nm laser therapy. 51 Intradermal botulinum toxin A injections improved quimp in patients with erythema telangiectasia rosacea with and without non-laser thermomechanical system.…”