RETIRED: Intrauterine Growth Restriction: Screening, Diagnosis, and Management

Lausman, Andrea; Kingdom, John; Gagnon, Robert; Basso, Melanie; Bos, Hayley; Crane, Joan; Davies, Gregory; Delisle, Marie-France; Hudon, Lynda; Menticoglou, Savas; Mundle, William; Ouellet, Annie; Pressey, Tracy; Pylypjuk, Christy; Roggensack, Anne; Sanderson, Frank

doi:10.1016/s1701-2163(15)30865-3

Cited by 262 publications

(208 citation statements)

References 51 publications

(1 reference statement)

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“…26 Our findings suggest that the risk for schizophrenia related to fetal size may lie with IUGR, a pathological mechanism associated in the general population with elevated rates of infant mortality and neurodevelopmental impairment in infants and children. 27,31,32 Precise timing of IUGR is often unknown. In the single subject in our sample clinically diagnosed with IUGR through serial ultrasounds, findings were normal at 15 weeks gestational age but showed progressively decelerating growth at 36 and 38.5 weeks.…”

Section: Sga Birth Weight Iugr and Aberrant Neurodevelopmental Trajmentioning

confidence: 99%

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Van

Butcher

Costain

et al. 2016

Genetics in Medicine

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Section: Sga Birth Weight Iugr and Aberrant Neurodevelopmental Trajmentioning

confidence: 99%

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Van

Butcher

Costain

et al. 2016

Genetics in Medicine

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“…This cohort study screened 53 IUGR fetuses for an antenatal fetal scan in a pregnant woman with age stational age of 27 weeks or more.The diagnosis of IUGR was made according to established criteria from SOGC clinical practice guideline August 2013 [5]. The data also included 48 appropriate for gestational age fetuses with healthy mothers with the comparable gestational week.…”

Section: Methodsmentioning

confidence: 99%

Altered Arterial Doppler Flow Pattern and Perinatal Outcome in Intrauterine Growth Restriction

Shetty

Nayak

Kumar

et al. 2017

Asian J Pharm Clin Res

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Objectives: Intrauterine growth restriction (IUGR) is one of the common conditions that interfere with the growth of the fetus accounting for 10-15% of pregnant woman. Literature explores a wide range of incidence of perinatal complication including mortality among IUGR pregnancies. Limited data available on these complications confined to coastal Karnataka and its association with abnormal arterial Doppler flow pattern. To study the perinatal complications associated with IUGR pregnancies and its prevalence in comparison to healthy controls of comparable gestational age. Methods:This cohort study screened 53 IUGR fetuses by an antenatal scan at gestational age of 27 weeks or more. The diagnosis of IUGR was made according to established criteria from SOGC clinical practice guidelines August 2013. The data also included 48 appropriate for gestational age fetuses with healthy mothers with the comparable gestational week. Experienced cardiac sonographer and gynecologist performed fetal echocardiography (ECHO) using Vivid 7, GE health-care system ECHO machine with the convex transducer of frequency 1.7-2.4 MHz. The study was conducted at south Indian tertiary care center.Results: This study included 53 IUGR cases and 48 non-IUGR controls. The mean age was 27±4.37 and 26.88±3.14 years in IUGR and non-IUGR groups, respectively. Fetal Doppler study variables showed a significant decrease in peak aortic velocity and velocity time integral which was not evident on other valves, though mitral antegrade flow during atrial contraction was found to be lower among IUGR group. In two-dimensional chamber quantification of IUGR group revealed significant increase in pulmonary artery dimension, right ventricular (RV) dimension and RV thickness than the control group (p<0.05). The anthropometric parameters such as weight and length; abdomen circumference was significantly lower in IUGR group, whereas head circumference found to be more in IUGR group (p<0.001). The gestational weeks at delivery was significantly different among two groups with IUGR group depicting the early delivery group. p<0.001(35.58±2.92 and 38.5±0.96 in IUGR and non-IUGR groups, respectively). IUGR group also had prolonged neonatal intensive care unit stay when compared to controls (p<0.001).Conclusions: IUGR carries profound course in altered Doppler indices and cardiac function which explore its prediction on mortality and adverse perinatal outcome. This study showed significant perinatal mortality accounting for 5.6% among IUGR cases when compared to normal. Although tissue Doppler indices show normal variants, IUGR possesses significant adverse perinatal outcome, however with lesser incidence compared to severe form of IUGR subsets who show altered tissue annular velocities.

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“…Growth restriction was defined as estimated foetal anthropometric parameters 16 , confirmed at birth, below the 10 th percentile for gestational age and sex. The severity of neonatal encephalopathy was estimated by Sarnat scoring based on abnormal neurologic signs, such as increased irritability and jitteriness, abnormal tone, abnormal primitive reflexes, altered consciousness, or convulsions, within the first 24 h of life 17 .…”

Section: Methodsmentioning

confidence: 99%

Untitled

2017

IJPSR

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Perinatal hypoxia results in poor circulation in internal organs, causing damage to the intestinal mucosa. Here, we aimed to evaluate the role of endothelial vasoconstrictor function in the formation of the intestinal mucous barrier in low-birth-weight neonates with hypoxicischemic encephalopathy (HIE). We comparatively analysed the concentrations of specific intestinal protective markers, i.e., serum mucin 2 (MUC2), serum intestinal trefoil factor (ITF), and faecal human β-defensin 2 (HBD2), and a marker of endothelial activity, i.e., serum endothelin-1 (ET-1), in early of postnatal life in 8 infants with moderate/severe HIE (group 1), 14 neonates with mild HIE (group 2), and 20 control infants using standard enzyme-linked immunosorbent assays. Markers of intestinal mucosa activity were not differentially expressed between infants in groups 1 and 2. Mean total concentrations of ITF and HBD2 were higher in groups 1 and 2 than in the control group (p < 0.05). In contrast, MUC2 concentrations were lower in infants of groups 1 and 2 than in the control infants. ET-1 expression was higher in group 2 than in group 1 and the control group on days 1-3 (p < 0.05). Spearman's rank-order correlation analysis showed that there were no significant relationships of ET-1 with MUC2 and HBD2. However, there was a significant negative correlation between ET-1 and ITF in group 1 infants. High serum ITF and faeces HBD2 levels accompanied low blood concentrations of MUC2, reflecting the depletion of Goblet cell function in response to hypoperfusion in low-birth-weight infants with HIE.

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RETIRED: Intrauterine Growth Restriction: Screening, Diagnosis, and Management

Cited by 262 publications

References 51 publications

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Altered Arterial Doppler Flow Pattern and Perinatal Outcome in Intrauterine Growth Restriction

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