RETIRED: Elective Single Embryo Transfer Following In Vitro Fertilization

Hughes, Everett C.; Young, David; Gysler, Matt; Hemmings, Robert; Goodrow, Gwendolyn J.; Min, Jason; Senikas, Vyta; Wong, Benjamin; Cheung, Anthony P.; Sierra, Sony; Carranza-Mamane, Belina; Case, Allison; Dwyer, Cathy; Graham, James R.; Havelock, Jon; Lee, Francis; Liu, Kimberly; Vause, Tannys

doi:10.1016/s1701-2163(16)34482-6

Cited by 67 publications

(33 citation statements)

References 105 publications

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“…The accumulative success rate could be improved after one ovarian stimulation and retrieval cycle. Therefore, along with the refinement of laboratory techniques, the proportion of FET has increased [7] dramatically since the first baby after the frozen-thawed embryo transfer (FET) cycle was born in 1984 [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Which one has a better obstetric and perinatal outcome in singleton pregnancy, IVF/ICSI or FET?: a systematic review and meta-analysis

Zhao

Zhang

et al. 2016

Reprod Biol Endocrinol

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BackgroundThe present study aims to compare which one has a better obstetric and perinatal outcome in singleton pregnancy, frozen embryo transfer (FET) or. in vitro fertilization treatment/intracytoplasmic sperm injection (IVF/ICSI)?MethodsMEDLINE, Google Scholar and the Cochrane Library were searched for the obstetric and perinatal outcomes in singleton pregnancy after assisted reproductive technology (ART) from inception until July 2016. Clinical trials, which compared obstetric/perinatal outcomes in singleton pregnancy after FET and IVF/ICSI-ET, were included. The primary outcome was low birth weight, preterm birth, perinatal mortality, still birth, and cesarean section.ResultsThirteen cohort studies with 126,911 women were included, of which 12, 11, 6, 6, 5 studies were used to analyze low birth weight, preterm birth, perinatal mortality, still birth, and cesarean section, respectively. IVF/ICSI is associated with a high risk of preterm birth (OR = 1.14, 95 % CI: 1.02, 1.28) and low birth rate (OR = 1.48, 95 % CI: 1.37, 1.60). There was no significant difference in the risk of the still birth (OR = 1.01, 95 % CI: 0.76, 1.35) and perinatal mortality (OR = 1.11, 95 % CI: 0.85, 1.46) between FET and IVF/ICSI. Singleton pregnancy after FET was associated with higher cesarean section rate compared with IVF/ICSI (OR = 0.85, 95 % CI: 0.80, 0.91).ConclusionsSingleton pregnancy after FET seems to have a better perinatal outcome compared with that after IVF/ICSI. Further randomized controlled trials which adjust for a variety of meaningful confounders are needed in order to draw sound conclusions.Electronic supplementary materialThe online version of this article (doi:10.1186/s12958-016-0188-3) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Which one has a better obstetric and perinatal outcome in singleton pregnancy, IVF/ICSI or FET?: a systematic review and meta-analysis

Zhao

Zhang

et al. 2016

Reprod Biol Endocrinol

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“…A 2006 Canadian study showed that DET was utilized in 55.8% of all ART procedures, with 46% of all births attributable to multiple pregnancy. Not only was there a high rate of twin births, but, when compared with singletons conceived via IVF, twins showed a 10-fold increased risk of preterm delivery (<37 weeks), a 7-fold increased risk of delivery prior to 32 weeks of gestation, and a 12-fold increased risk for birth weight less than 2.5 kg [14]. In order to remedy the increased likelihood of twin or multiple births associated with DET for IVF-seeking couples, it is imperative to implement techniques like SET that will reduce the number of embryos necessary for successful pregnancy while avoiding potential complications.…”

Section: Set Versus Det and Met Multiple Pregnancy And Metmentioning

confidence: 99%

“…The longterm costs associated with IVF twin birth are significantly higher compared to that of an IVF singleton; yet, DET is more often utilized, mostly due to SET often requiring multiple cycles of uterine embryo transfers [11,14,32,34,35]. The use of DET often results in an increased financial burden both on the family and healthcare system, so much so that legislation has been, and continues to be, globally enacted in an attempt to decrease the use of DET in favor of SET [36].…”

Section: Widespread Costs Of Ivf Proceduresmentioning

confidence: 99%

Assessment of the Field of Assisted Reproductive Technology: Improvements and the Future of Human In Vitro Fertilization

Brown¹

2015

JFIV Reprod Med Genet

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In vitro fertilization (IVF), a form of assisted reproductive technology, has expanded since its introduction in the 1970's to enable patients with prolonged infertility and/or clinical complications to produce biological offspring. This review analyzes the topics of controversy surrounding IVF, weighing evidence concerning contemporary fertility techniques that aim to advance the field of IVF. A comparison of single embryo transfer to double embryo transfer, in the context of economic expenditure and the likelihood of multiple pregnancy, provides support for electing the former. An ethically controversial topic is preimplantation genetic screening, a technology with the potential to reduce the incidence of genetic abnormalities, thereby increasing rates of healthy pregnancies. Lastly, the integration of in vitro maturation (IVM) can allow for a more diverse patient population to benefit from IVF treatment, while simultaneously avoiding several of the associated disadvantages. The future of IVF rests on continued research, and the resulting widespread integration of increasingly effective methods.

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“…IVF, with restrictions on the maximum number of embryos to be transferred in some countries and less restrictive guidelines in others, is associated with far fewer high-order multiple pregnancies. Furthermore, recent technological advances such as extended embryo culture to the blastocyst stage and preimplantation aneuploidy screening have increased the use of elective single embryo transfer, which has further reduced the number of multiple pregnancies in women undergoing IVF cycles [64,65].…”

Section: Multiple Pregnanciesmentioning

confidence: 99%