RETIRED: Adhesion Prevention in Gynaecological Surgery

The Impact of Socioeconomic and Anamnestic Characteristics on Quality of Life and Sexual Function in Women with Endometriosis

“…Consequently we may hypothesize that the repetitive surgical interventions may negatively influence quality of life and sexual function and not the disease itself. Moreover, previous studies demonstrated that every surgical treatment induces an increase of adhesions and risk for more serious complications, which may affect the quality of life (19)(20)(21).…”

Reduction of Postoperative Adhesions after Laparoscopic Surgery for Endometriosis by Using a Novel Anti-Fibrotic Drug Pirfenidone: A Randomized Double Blind Study

“…Different methods of adhesions prevention can be classified into those associated directly with the surgical techniques and those involving the use of either drugs or the application of barrier agents [15,17,18].…”

“…They include non-steroidal anti-inflammatory drugs, corticosteroids, heparin, fibrinolytic drugs, antibiotics, colchicine, calcium channel blockers, vascular endothelial growth factor inhibitors, platelet-activating factor inhibitors, collagen α1 inhibitors, interleukin-6 inhibitors, melatonin, progestagens, and GnRH analogues. Interference with inflammation and prevention of fibrin formation is the rational for their use [15,[18][19][20].…”

Efficacy of ovarian suspension to round ligament with a resorbable suture to prevent postoperative adhesions in women with ovarian endometrioma: follow-up by transvaginal hydrolaparoscopy

“…This causes activation of the extrinsic pathway of the coagulation cascade and the formation of an exudate rich in fibrin [19]. Adhesions can lead to infertility, dyspareunia, chronic pelvic pain, and complications at repeated surgery [20,21]. Adhesions may produce disruption of the normal anatomy, thus altering normal tubal performance.…”

“…The most common site of postoperative adhesions formation is the ovary [12,22]. Although several surgical measures and systemic pharmacologic treatments for adhesions prevention have been proposed, the rate of periovarian adhesion formation was not significantly reduced [13,[20][21][22]. The high incidence of postoperative adhesions in endometriosis patients and their clinical significance underline the importance of modifying surgical technique in order to reduce potential adhesion formation.…”