Retinyl palmitate flexible polymeric nanocapsules: Characterization and permeation studies

Enhanced In Vitro Skin Deposition Properties of Retinyl Palmitate through Its Stabilization by Pectin

“…No drug was detected in the receiver phase although it is not a target site of RP. This might be attributed to the low skin permeability of retinoids (Teixeira et al ., 2010) or the instability of RP under the experimental conditions employed.…”

“…Retinoids usually present low permeation into the skin, because most of the drug is broken before percutaneous absorption or still remains on the surface due to stratum corneum (SC) known as an effective barrier (Ihara et al ., 1999; Carlotti et al ., 2002; Carlotti et al ., 2004; Teixeira et al ., 2010). …”

Confocal Laser Scanning Microscopy as a Tool for the Investigation of Skin Drug Delivery Systems and Diagnosis of Skin Disorders

“…After ex vivo skin delivery, by sequential excitation of dual-labeled liposomes and vesicles carrying diclofenac, it was possible to show that the vesicles penetrated intact down to the epidermis and the fluorescence intensity was higher and predominantly accumulated in the inter-corneocytes spaces [22]. Teixeira et al (2010) [58], taking the advantage that the vitamin A (retinyl palmitate) fluoresces due to the presence of cromophore in its structure, obtained dual-labeled images after in vitro studies using elastic polymeric nanocapsules, marked with Nile blue, carrying the vitamin. The images (Figure 6) showed that the nanocapsule did not penetrate the skin carrying the vitamin, but a deep permeation (around 30 μm) of both was observed, which suggests that the drug present in deep skin layers was released from nanocapsules in the superficial skin layers.…”

Topical Administration of Anticancer Drugs for Skin Cancer Treatment

“…However, low drug loading and drug expulsion during storage can be a limiting factor for some therapeutic treatments. Both SLNs and polymeric nanoparticles have been shown to promote sustained drug release and protection against drug degradation when topically applied (Teixeira et al, 2010;Marquele-Oliveira et al, 2010). In addition, they allow for modifications to matrix softness and superficial charges, adjustments that may improve skin targeting.…”