Retinopathy of Prematurity in Neonates and its Risk Factors: A Seven Year Study in Northern Iran

Rasoulinejad, Seyed Ahmad; Montazeri, Mohammad

doi:10.2174/1874364101610010017

Cited by 16 publications

(9 citation statements)

References 19 publications

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“…328 These results have been replicated in multiple subsequent studies, both for the risk of incident ROP and of treatment-requiring ROP. 6,10,11,13,14,17,18,21,47,57,65,75,77,94,102,109,114,122,125,135,138,143,147,152,157,174,202,204,216,228,231,233,236,240,246,255,263,266,271,276,282,283,285,308,311,312,315,335,337,348,362,367,371,373,378,391,398,405,406,410,412,418…”

Section: Major Risk Factorsmentioning

confidence: 99%

“…88,419 A number of subsequent studies found the duration of oxygen therapy to be a significant risk factor for severe ROP. 10,13,39,57,71,74,109,114,131,149,152,167,231,236,257,264,276,283,312,313,315,364,401,412,428 Similarly, many studies identified prolonged mechanical ventilation as a risk factor for any or severe ROP. 11,12,36,39,53,57,106,120,157,167,187,211,232,263,266,274,275,286,335,337,345,348,368,370,405,406,412,417…”

Section: Major Risk Factorsmentioning

confidence: 99%

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Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

358

337

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Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of prematurity, and to determine future directions in management of and research in ROP.

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Section: Major Risk Factorsmentioning

confidence: 99%

Section: Major Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

358

337

View full text Add to dashboard Cite

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“…Furthermore, the hyperglycemic status in DR patients plays a dual role in the progression of nephrological diseases (e.g., albuminuria), along with DR, due to the preceded systemic inflammation (4). Therefore, numerous DR patients suffer from albuminuria (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Association of Microalbuminuria and Bevacizumab Therapy Outcomes in Diabetic Retinopathy Patients

Rasoulinejad

2021

Nephro-Urol Mon

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Background: Diabetic retinopathy (DR) is a visual impairment-related eye disease developed by long-term hyperglycemic status. Diabetic condition in DR patients leads to diabetic organopathies (e.g., renal failure). Albuminuria, as a hallmark of renal failure, can be correlated with visual indicators in DR patients. Objectives: This study aimed to investigate the role of albuminuria status in visual acuity (VA) and bevacizumab therapy outcomes in DR patients. Methods: In this retrospective study, 48 DR patients were admitted to the Ophthalmology Center of Ayatollah Rouhani Hospital, affiliated with Babol University of Medical Sciences, Babol, Iran. The retinopathy status and VA were identified before and after treatment through 45 days of bevacizumab therapy. In addition, fast blood sugar, hemoglobin A1c, urine albumin, and urine creatinine were evaluated using standard laboratory methods. Results: The VA value before treatment in microalbuminuric DR patients (0.106 ± 0.036) was significantly lower than non-microalbuminuric DR patients (0.347 ± 0.286; P < 0.001). Furthermore, VA value after treatment in microalbuminuric DR patients (0.115 ± 0.071) was significantly lower than non-microalbuminuric DR patients (0.355 ± 0.272; P < 0.001). There was no significant difference in the percentage of VA increase between microalbuminuric and non-microalbuminuric patients. Moreover, the albumin-to-creatinine ratio (ACR) was correlated with a lower VA level before and after treatment (P < 0.001 for both). There was no correlation between the percentage of VA increase with ACR, albumin, and creatinine. Conclusions: The current study results showed that different VA before and after bevacizumab therapy status was correlated with microalbuminuria status. Additionally, microalbuminuria status did not affect the percentage of VA increase in the treatment of DR patients.

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“…Exposing premature infants to supplemental oxygen is an important risk factor for developing ROP [13, 14]. Increased duration and number of hyperoxia events may increase the risk of ROP [15, 16]. Therefore, consensus guideline for resuscitation of preterm infants has been revised to deliver a low fraction of inspired oxygen [17].…”

Section: Introductionmentioning

confidence: 99%

Aerosol therapy in relation to retinopathy of prematurity in mechanically ventilated preterm infants

et al. 2019

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Background Aerosol administration is increasingly being used as a therapeutic intervention for mechanically ventilated preterm infants. However, the effects of inhalation therapy on retinopathy of prematurity (ROP) have not yet been explored. Methods A retrospective cohort study was conducted in a tertiary level neonatal intensive care unit (NICU) from 2011 to 2013. All preterm infants with a gestational age (GA) of 24~29 weeks receiving invasive intubation for more than 1 week in the NICU were included. Infants with severe congenital anomalies were excluded. ROP was defined as stage II or greater according to medical records by ophthalmologists. A multivariate logistic regression model was used to estimate the risk of ROP in relation to inhalation therapy after adjusting for confounders. Results In total, 205 infants were enrolled in this study, including 154 with inhalation therapy and 51 without inhalation therapy. Univariate analyses showed an association of inhalation with the following characteristics: sex ( p = 0.047), GA ( p = 0.029), sepsis ( p = 0.047), bronchopulmonary dysplasia (BPD) ( p < 0.001), and ROP ( p = 0.001). Furthermore, logistic regression analysis indicated that inhalation therapy was an independent risk factor for ROP (odds ratio (OR) = 2.639; 95% confidence interval (CI) = 1.050~6.615). In addition, infants with a GA of 24~25 weeks (OR = 6.063; 95% CI = 2.482~14.81) and 26~27 weeks (OR = 3.825; 95% CI = 1.694~8.638) were at higher risk of ROP than those with a GA of 28~29 weeks. Other factors – including sex, sepsis, BPD, and delivery mode – did not carry significant risk. Conclusion Aerosol therapy with pure oxygen delivery is associated with ROP. Clinicians should exercise great caution when conducting aerosol therapy with excess oxygen in mechanically ventilated preterm infants.

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Retinopathy of Prematurity in Neonates and its Risk Factors: A Seven Year Study in Northern Iran

Cited by 16 publications

References 19 publications

Retinopathy of prematurity: a review of risk factors and their clinical significance

Retinopathy of prematurity: a review of risk factors and their clinical significance

Association of Microalbuminuria and Bevacizumab Therapy Outcomes in Diabetic Retinopathy Patients

Aerosol therapy in relation to retinopathy of prematurity in mechanically ventilated preterm infants

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