Retinopathy of Prematurity and Possible Relation Between Postnatal Cytomegalovirus Infection

Josa, M. I.; García, María José Cuenca; López, Esther García; Marieges, Teresa; Miquel, R.; Armendáriz, Laura Cecilia; Moliner, Ernesto Clar

doi:10.1007/s12098-022-04165-5

Cited by 2 publications

(2 citation statements)

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“…In a retrospective cohort study by Chien et al on the Taiwanese population, involving a research group of 5797 patients, a significantly higher occurrence of late-onset corneal inflammation was shown in patients with cCMV ( p = 0.028) [ 135 ]. It is important to emphasize that reactivation of inflammation characterized by retinitis and vitreous body inflammation is observed by authors treating preterm infants for retinopathy of prematurity (ROP) [ 136 , 137 ]. In these cases, hCMV infection is nosocomial and arises in response to the compromised immune defenses of heavily and extremely low birth weight preterm infants.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Complications, Diagnosis, and Treatment of Congenital Human Cytomegalovirus Infection

Modrzejewska,

Połubiński,

Zdanowska

2024

JCM

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Background: Human cytomegalovirus (hCMV) is the most common etiological agent of congenital infections seen in newborns. Among the most commonly observed complications in children with congenital human cytomegalovirus infection are those affecting the visual system. Ocular complications of congenital CMV (cCMV) are a topic rarely addressed in the literature, which prompted the authors to update the available knowledge with the latest data. Methodology: English-language literature published between April 2000 and November 2023 (PubMed, NIH, Google Scholar) was analyzed for ocular complications of cCMV. The data obtained were categorized according to the ocular area involved and the incidence. A compilation of criteria for the symptomatic form of cCMV was also created. Results: The cCMV complications described in the literature affect all parts of the visual system: the anterior segment, the posterior segment, the posterior visual pathways, and the visual cortex. The most commonly described ocular complication of cCMV is choroidal and retinal scarring. Conclusions: Ophthalmic complications of cCMV can cause severe visual disturbances. Ophthalmic diagnosis in newborns should include hCMV PCR testing, which has the highest sensitivity and specificity. In the symptomatic form of cCMV, treatment should be instituted according to recommendations. A consensus should be established for screening of primary hCMV infection in pregnant women, the way in which to define the symptomatic form of cCMV, and the appropriateness and standards of treatment for primary hCMV infection in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Ophthalmic Complications, Diagnosis, and Treatment of Congenital Human Cytomegalovirus Infection

Modrzejewska,

Połubiński,

Zdanowska

2024

JCM

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“…At the same time, we found a higher rate of common complications implicated with immaturity in infants with postnatal CMV infection. Some authors have mentioned postnatal CMV infection in preterm infants as a risk factor for the development of chronic lung disease or retinopathy of prematurity [20][21][22][23]. Current evidence definitely indicates that postnatal CMV infection, as well as prematurity-related complications such as chronic lung disease, affects the same high-risk group of immature infants.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Postnatal Cytomegalovirus Infection on (Micro)structural Cerebral Development in Very Preterm Infants at Term-Equivalent Age

Pellkofer,

Hammerl,

Griesmaier

et al. 2023

Neonatology

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Introduction: There are some data indicating a negative impact of postnatal cytomegalovirus (CMV) infection on long-term neurodevelopmental outcome of preterm infants. So far, there is only little knowledge about a cerebral imaging correlate of these neurodevelopmental alterations induced by postnatal CMV infection in preterm infants. The aim of the current study was to investigate the effect of postnatal CMV infection on the incidence of brain injury and on microstructural brain maturation in very preterm infants at term-equivalent age. Methods: Infants <32 gestational weeks (02/2011–11/2018) received cerebral MRI including axial diffusion-weighted images at term-equivalent age. All infants were screened for CMV infection using urine/saliva samples, and infection was regarded as acquired postnatal if a sample became positive >5 postnatal days. We compared brain injury as well as fractional anisotropy and apparent diffusion coefficient in 14 defined cerebral regions between infants with and without postnatal CMV infection. Results: 401 infants were eligible, of whom 18 (4.5%) infants had a postnatal CMV infection. There were no significant differences in rates of brain injury or in microstructural brain development between both groups. This applied equally to the subgroup of infants <28 gestational weeks. Conclusion: Although infants with postnatal CMV infection were born more immature and more frequently suffered from complications related to immaturity, we neither observed a higher rate of preterm brain injury nor disadvantageous alterations in microstructural brain maturation at term-equivalent age.

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Retinopathy of Prematurity and Possible Relation Between Postnatal Cytomegalovirus Infection

Cited by 2 publications

References 10 publications

Ophthalmic Complications, Diagnosis, and Treatment of Congenital Human Cytomegalovirus Infection

Ophthalmic Complications, Diagnosis, and Treatment of Congenital Human Cytomegalovirus Infection

The Effect of Postnatal Cytomegalovirus Infection on (Micro)structural Cerebral Development in Very Preterm Infants at Term-Equivalent Age

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