Retinopathy in systemic lupus erythematosus: pathogenesis and approach to therapy

Giorgi, Dario; Pace, F.; Giorgi, Antonella; Bonomo, Lorenzo; Gabrieli, C. Balacco

doi:10.1016/s0198-8859(99)00035-x

Cited by 37 publications

(24 citation statements)

References 43 publications

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“…The CRA supplies the blood flow to the retina, and retinal ischemia is the main chain in the pathogenesis of vascular diseases of the eye. 13,14 Therefore, measurement of the blood flow of the CRA with CDI could be a good indicator of the capillary blood flow of the retina. In this study, we measured PSV, EDV, TVI, PI and RI of CRA blood flow in subjects.…”

Section: Discussionmentioning

confidence: 99%

Changes of Central Retinal Artery Blood Flow and Endothelial Function in Patients with Coronary Artery Disease

et al. 2007

Current Eye Research

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Section: Discussionmentioning

confidence: 99%

Changes of Central Retinal Artery Blood Flow and Endothelial Function in Patients with Coronary Artery Disease

et al. 2007

Current Eye Research

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“…These patients tend to develop central or branch artery and vein occlusion or with extensive retinal capillary non-perfusion complications including neovascularization, vitreous hemorrhage and tractional retinal detachment. Retinal vasculitis, vitiritis, posterior scleritis and central retinal artery occlusion also reported with higher prevelance in aPL positive patients [110][111][112][113]. APS associated neuro-ophthalmic changes are probably related to blood supply hazard and optic nerve demyelization and include anterior non-arterial ischemic neuropathy (NAION), retro-bulbar neuritis and orbital ischemic syndrome on catastrophic APS [114,115].…”

Section: Role Of Antiphospholipid Syndromementioning

confidence: 99%

Ocular Manifestations in Systemic Lupus Erythematosus

Maghsoudlou¹

2015

Rheumatology (Sunnyvale)

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Systemic lupus erythematosus (SLE) is an autoimmune disease manifest with multiple organ system involvement. Even though the eye is not part of the diagnostic criteria, once it gets affected, it will alter patients' quality of life. The purpose of this review is to point out the significance of ocular manifestations in SLE and to emphasize the importance of possible blinding complications such as peripheral ulcerative keratitis, scleritis, and SLE retinopathy/ choroidopathy. The condition can be even worse when SLE is accompanied with antiphospholipid syndrome. In addition to the disease itself, several treatment agents that are used in SLE are responsible for vision threatening conditions; thus they have to be given with caution because of potential side effects, including cataract, glaucoma, and chloroquine maculopathy.

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“…From the clinical and therapeutic point of view, it is important to distinguish this aPL-induced thrombotic retinopathy from that seen in SLE patients as a result of vasculitis or atherosclerosis. With the aid of both ophthalmoscopy and retinal fluorescent angiography, thrombosis of the retinal small or large vasculature can be satisfactorily demonstrated [62].…”

Section: Eyementioning

confidence: 99%

Microthrombotic/Microangiopathic Manifestations of the Antiphospholipid Syndrome

Praprotnik

Ferluga

Vizjak

et al. 2008

Clinic Rev Allerg Immunol

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The paper presents an overview of clinical manifestations and histopathologic findings in different organs in microvascular thrombotic and microangiopathic antiphospholipid syndrome (MAPS). Subsets of antiphospholipid syndrome (APS) are presented and defined. Clinico-pathologic correlations seem insufficient so far, because of a lack of detailed systematic studies of the histopathology in different organs. Based on their own autopsy and biopsy studies, the authors propose a novel categorization of histopathologic lesions that occur in patients with classic and catastrophic APS. In addition to the already accepted category of a microvascular thrombotic type of lesions, microangiopathic lesions consistent with thrombotic microangiopathy are proposed to be included in new revised classification criteria for definite APS. Microvascular thrombotic and so far underestimated microangiopathic histopathologic lesions have been shown to appear in various combinations and of different ages in patients with both classic and catastrophic APS, which fits into the concept of MAPS. These preliminary findings of our studies are also in line with the most recent hypothesis of two main mechanisms in the pathogenesis of APS, emphasizing a key role of endothelial cell affection induced by aPL on the one hand and interference with coagulation cascade on the other side.

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Retinopathy in systemic lupus erythematosus: pathogenesis and approach to therapy

Cited by 37 publications

References 43 publications

Changes of Central Retinal Artery Blood Flow and Endothelial Function in Patients with Coronary Artery Disease

Changes of Central Retinal Artery Blood Flow and Endothelial Function in Patients with Coronary Artery Disease

Ocular Manifestations in Systemic Lupus Erythematosus

Microthrombotic/Microangiopathic Manifestations of the Antiphospholipid Syndrome

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