Retinopathy in Hemoglobin C Trait (AC Hemoglobinopathy)

Moschandreou, Miltos; Galinos, Spiros; Valenzuela, Raúl; Constantaras, Alexander A.; Goldberg, Morton F.; Adams, Joel C.

doi:10.1016/0002-9394(74)90456-5

Cited by 20 publications

(8 citation statements)

References 16 publications

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“…Haemoglobinopathies in which ocular involvement has been reported include homozygous sickle cell anaemia (HbSS) (Goodman et al, 1957;Condon and Serjeant, 1976), sickle cell trait (HbAS) (Gerde, 1974;Radius and Finkelstein, 1976), sickle cell haemoglobin C disease (HbSC) (Goldberg, 1971;Condon and Serjeant, 1972a;Ryan, 1974), sickle cell P-thalassaemia (HbS P-thal) Condon and Serjeant, 1972b), and haemoglobin C trait (HbAC) (Moschandreau et al, 1974). Angioid streaks have been noted in association with 4 of the above disorders, namely, HbSS (Geeraets and Guerry, 1960;Condon and Serjeant, 1976), HbAS (Gerde, 1974), HbSC (Condon and Serjeant, 1972a;Nagpal et al, 1976), and HbS ,-thalassaemia Nagpal et al, 1976). Their incidence in association with haemoglobinopathies as a whole has been estimated at 0-94% (Paton, 1972).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly angioid streaks have been found in only 2 cases each of HbS r-thalassaemia Nagpal et al, 1976) and HbSC (Condon and Serjeant, 1972a;Nagpal et al, 1976). Angioid streaks have not been reported in pure oz-thalassaemia or any variety of P-thalassaemia.…”

mentioning

confidence: 92%

“…Angioid streaks have been noted in association with 4 of the above disorders, namely, HbSS (Geeraets and Guerry, 1960;Condon and Serjeant, 1976), HbAS (Gerde, 1974), HbSC (Condon and Serjeant, 1972a;Nagpal et al, 1976), and HbS ,-thalassaemia Nagpal et al, 1976). Their incidence in association with haemoglobinopathies as a whole has been estimated at 0-94% (Paton, 1972).…”

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confidence: 99%

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Ocular findings in a case of haemoglobin H disease.

Daneshmend¹

1979

British Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

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confidence: 92%

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confidence: 99%

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Ocular findings in a case of haemoglobin H disease.

Daneshmend¹

1979

British Journal of Ophthalmology

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“…Changes in the macular capillary bed were ob served in 29 of 100 patients [40], A prolifer ative retinopathy has also been confirmed to gether with a haemoglobinopathy involving haemoglobin C [43].…”

Section: Haematological Causesmentioning

confidence: 99%

Retinal Telangiectasis and Proliferation of the Retinal Vessels in a Family

Schmidt¹,

Soriano²

1993

Ophthalmologica

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A 20-year-old woman presented with a marked proliferative retinopathy of the entire central region of the retina in both eyes, with veil-like epiretinal gliovascular membranes and isolated spots of haemorrhaging. The outer region of the retina was unremarkable. Her 49-year-old mother showed perimacular telangiectases in both eyes. The vascular system of both patients were medically sound, and, in particular, the blood pressure, blood sugar and blood picture were normal, with nc signs of heart, kidney, lung or liver disease. The first patienl had been a heavy smoker for 6 months, and the second did noi smoke. The 84-year-old mother of the second patient was blind following bilateral Horton’s temporal arteritis.

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“…This vascular modification occurs in the peripheral retina but also in the macular capillaries. HbSC forms are associated with more severe retinopathy including neovascularization, [16][17][18][19] whereas HbSS forms are associated with more severe systemic complications. 16,19,20 Recent optical coherence tomography findings demonstrate retinal thinning of the temporal zone of the macula, predominantly in the inner retina layers in patients affected with early sickle cell retinopathy stages.…”

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confidence: 99%