Retinopathy Associated with Acute Pancreatitis

Snady-McCoy, Lory; Morse, Peter H.

doi:10.1016/0002-9394(85)90789-5

Cited by 27 publications

(4 citation statements)

References 22 publications

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“…Fluorescein angiography showed clinical features of our patient were similar to those of cases of pancreatitis-associated retinopathy previously reported. [2][3][4] He also had a long history of alcohol intake. Severity of acute pancreatitis is not associated with the presence of retinopathy.…”

Section: Case Reportmentioning

confidence: 99%

“…Rapid development of visual disturbance is a common and dramatic presentation of this syndrome, although the severity of visual impairment can vary widely, depending upon the specific areas of retina involved in the pathological changes. 3,4 The pathogenesis of Purtscher-like retinopathy is a matter for debate. Current evidence suggests that leukocytic emboli form when pancreatic damage releases proteolytic enzymes into the systemic circulation, thereby causing activation of the complement cascade and the formation of C5a-induced leukocyte, platelet, and fibrin aggregates.…”

Section: Case Reportmentioning

confidence: 99%

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Purtscher-like retinopathy associated with acute pancreatitis

et al. 2005

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The case of a 35-year-old patient with acute alcoholic pancreatitis who developed sudden loss of visual acuity is described. The ophthalmoscopic examination revealed diffuse retinal whitening of the posterior pole with confluent cotton-wool spots. Fluorescein angiogram showed retinal arteriolar occlusion. The findings were compatible with Purtscher-like retinopathy. Computed tomography of the abdomen demonstrated enlarged liver and pancreas with edema and inflammation. The pathogenesis of this form of retinopathy still remains uncertain and there is no specific treatment available.

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Purtscher-like retinopathy associated with acute pancreatitis

et al. 2005

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“…Retinopathy of pancreatitis with bilateral multiplex cotton-wool patches and retinal hemorrhages is a rare complication of the severe acute pancreatitis (Kincaid et al 1982;Snady-McCoy & Morse 1985). The pathogenesis of the retinopathy is not understood.…”

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confidence: 99%

Clinicopathology of a case with retinopathy of pancreatitis

Holló

Bobek

1993

Acta Ophthalmologica

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Bilateral retinopathy of pancreatitis developed in a 36-year-old male patient during recurrent acute necrotizing pancreatitis. The retinopathy remained clinically unchanged between the detection and the death 6 days later. Characteristics of the retinal lesions were histologically similar to cotton-wool spots of other origin, but all the retinal vessels including vessels around and in the cotton-wool spots were intact and contained plasma and red blood cells. Absence of vascular occlusion and endothelial damage suggests that in acute pancreatitis vascular embolisation in the retina is not necessary to the development of cotton-wool patches.

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“…This theory has not been supported by pathological and pathophysiological findings (Friess et al 1987;Mayer 1985). Re-820 cently, retinopathy associated with acute pancreatitis was considered a complication to a 60-80 pm granulocyte emboli, induced via an activation of the complement system by appearance of pancreatic enzymes in the blood (Balazs et al 1985;Behres-Baumann & Scheurer 1991;Jacob et al 1981;Jipp et al 1985;Mohay 1989;Shapiro &Jacob 1982;Snady-McCoy & Morse 1985). Experimental granulocyte embolus formation induced by active trypsin has been studied in vitro and in vivo in mesenterial arterioles of rats (Craddock et al 1977;Hammerschmidt et al 1981;Ruddy et al 1972).…”

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confidence: 99%

Is retinopathy in pancreatitis caused by leukocyte emboli?

Holló

Popik

1992

Acta Ophthalmologica

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The theory of granulocyte embolization in the retinal arterioles in acute pancreatitis cannot account for several aspects of the ophthalmic complication. Therefore we studied retinal circulation by fluorescein angiography, light and transmission electron microscopy following the first six hours of acute experimental necrotizing pancreatitis. The studied period was characterized by high serum lipase and amylase concentrations, hypocalcemia, necrosis of the pancreatic tissue and preceded the development of hypovolemic shock. Ophthalmoscopy and fluorescein angiography revealed no pathologic alterations and no granulocyte aggregation was found. Our results suggest that granulocyte aggregation induced by pancreatic enzymes is not the reason for the ophthalmic circulatory disturbances in acute pancreatitis.

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Retinopathy Associated with Acute Pancreatitis

Cited by 27 publications

References 22 publications

Purtscher-like retinopathy associated with acute pancreatitis

Purtscher-like retinopathy associated with acute pancreatitis

Clinicopathology of a case with retinopathy of pancreatitis

Is retinopathy in pancreatitis caused by leukocyte emboli?

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