Retinopathy among Adult Diabetics and Its Predictors in Northwest Ethiopia

Takele, Mulualem Birhan; Boneya, Dube Jara; Meheretu, Hailemariam Abiy Alemu; Birlew, Tesfa; Birhanu, Molla Yigzaw; Alemu, Simegn; Anto, Tsige Gebre

doi:10.1155/2022/1362144

Cited by 6 publications

(9 citation statements)

References 27 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The twenty-six studies [20,25,26,, six studies [57][58][59][60][61][62] and two studies [63,64] were conducted using cross-sectional, retrospective cohort and case-control study designs respectively. Regarding geographical region, seventeen studies [20, 25, 26, 35, 36, 38, 40, 43, 45, 49-51, 55, 56, 60-62] were conducted in Amhara, eight studies [39,41,44,48,52,58,59,63] were conducted in Oromia, five studies [42,46,53,57,64] were conducted in Addis Ababa, three studies [37,47,54] were conducted in Southern nations, nationalities and peoples, and one study [34] was conducted in Sidama region.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Visual impairment among diabetes patients in Ethiopia: A systematic review and meta-analysis

Aytenew,

Kefale,

Birhane

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Introduction The increased prevalence of visual impairment among diabetes patients has become a major global public health problem. Although numerous primary studies have been conducted to determine the prevalence of visual impairment and its associated factors among diabetes patients in Ethiopia, these studies presented inconsistent findings. Therefore, this review aimed to determine the pooled prevalence of visual impairment and identify associated factors among diabetes patients. Methods An extensive search of literature was done on PubMed, Google Scholar, and Web of Sciences databases. A manual search of the reference lists of included studies was performed. A weighted inverse-variance random-effects model was used to calculate the pooled prevalence of visual impairment. Results A total of 34 eligible primary studies with a sample size of 11,884 participants were included in the final meta-analysis. The pooled prevalence of visual impairment was 21.73% (95% CI: 18.15, 25.30; I2 = 96.47%; P<0.001). Diabetes mellitus with a duration of diagnosis ≥10 years [AOR = 3.18, 95% CI: 1.85, 5.49], presence of co-morbid hypertension [AOR = 3.26, 95% CI: 1.93, 5.50], poor glycemic control [AOR = 4.30, 95% CI: 3.04, 6.06], age ≥56 years [AOR = 4.13, 95% CI: 2.27, 7.52], family history of diabetes mellitus [AOR = 4.18 (95% CI: 2.61, 6.69], obesity [AOR = 4.77, 95% CI: 3.00, 7.59], poor physical activity [AOR = 2.46, 95% CI: 1.75, 3.46], presence of visual symptoms [AOR = 4.28, 95% CI: 2.73, 6.69] and no history of eye exam [AOR = 2.30, 95% CI: 1.47, 3.57] were significantly associated with visual impairment. Conclusions The pooled prevalence of visual impairment was high in Ethiopia. Diabetes mellitus with a duration of diagnosis ≥10 years, presence of co-morbid hypertension, poor glycemic control, age ≥56 years, and family history of diabetes mellitus, obesity, poor physical activity, presence of visual symptoms, and no history of eye exam were independent predictors. Therefore, diabetic patients with these identified risks should be screened, and managed early to reduce the occurrence of visual impairment related to diabetes. Moreover, public health policy with educational programs and regular promotion of sight screening for all diabetes patients are needed.

show abstract

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The quality of each study was evaluated using the Joanna Briggs Institute (JBI) quality appraisal criteria [67]. Twenty-six studies [20,25,26,, six studies [57][58][59][60][61][62] and two studies [63,64] were appraised using JBI checklist for cross-sectional, cohort and case-control studies, respectively.…”

Section: Quality Appraisal Of the Included Studiesmentioning

confidence: 99%

Visual impairment among diabetes patients in Ethiopia: A systematic review and meta-analysis

Aytenew,

Kefale,

Birhane

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…The Schoenfeld formula (Schoenfeld, 1983) was used for manual calculation: The hazard ratios for three predictors signi cantly associated with diabetic retinopathy in a study conducted at the Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar (45), were calculated (Table 1). Therefore, the nal sample size for this study was 376.…”

Section: Sample Size Calculation and Sampling Proceduresmentioning

confidence: 99%

Incidence of Diabetic Retinopathy and Predictors among Adult Diabetic Patients in Central and Southern Ethiopia: A Multicentre Retrospective Cohort Study.

Barata,

Abiraham,

Yakob

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Diabetic retinopathy (DR) is emerging as a global public health issue that may result in visual impairment. It has become the leading cause of blindness among working-age adults globally, despite established treatments that can reduce the risk by 60%. Disease progression, as indicated by longitudinal HbA1c measurements, may affect the time of interest (retinopathy). Hence, poor glycemic control increases and hastens the risk of retinopathy. Objective This study aimed to determine the incidence of diabetic retinopathy and its predictors among adult diabetic patients in public hospitals in Central and Southern Ethiopia. Methods A retrospective follow-up study was conducted at selected hospitals in Central and Southern Ethiopia among newly diagnosed patients with adult diabetes between January 1, 2015, and June 30, 2022. A systematic random sampling technique was applied. The data were collected and entered into Epi-data version 4.6.0.2 and exported to STATA version 14 for analysis. Descriptive statistics of the variables were obtained. The Cox proportional hazard assumption was checked. The Cox regression model was used to quantify the effects of covariates on the time to diabetic retinopathy. A p value less than 0.25 was the cut-off point for selecting variables for the bivariable analysis and candidates for the final analysis. In the multivariable analysis, variables with a p value less than 0.05 and a corresponding 95% confidence interval in the final model were used. Model adequacy was checked. Results A total of 376 adult diabetic patients were followed for 45752 person-months. Overall, 96 (25.5%) patients developed diabetic retinopathy, with an incidence rate of 11.7 per 1000 person-months of observation. Positive proteinuria (AHR = 2.19: 95% CI: 1.18, 4.08), hypertension (Yes) (AHR = 2.23: 95% CI: 1.39, 3.55) and type II DM (AHR = 2.89: 95% CI: 1.19, 7.05) were identified as significant predictors of diabetic retinopathy. Conclusion The incidence rate of diabetic retinopathy was high. Hypertension, proteinuria and type of diabetes were identified as predictors of diabetic retinopathy. Aggressive management should be implemented, and DM patients with hypertension and positive proteinuria should be followed to optimize positive outcomes.

show abstract

“…Finally, fifteen studies were reviewed for co-morbid HTN [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] (Table 2), six studies for poor glycemic control [21,22,24,25,28,32] (Table 3), and five studies for the duration of diabetic illness [21,22,25,27,31] (Table 4). Of the total studies; five were conducted in the Amhara region [21,23,27,30,34], five in Addis Ababa [24,26,29,32,35], three in the Oromia region [25,31,33], and two in South Nations and Nationalities people (SNNP) of Ethiopia [22,28].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…All the studies were published between the years 2015 and 2022. Regarding the study design, eight studies were cross-sectional [21-23, 26, 27, 32, 34, 35], five studies were cohort [28][29][30][31]33], and two studies were case-control [24,25]. The overall quality score of the included studies' was �7.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Determinants of diabetic retinopathy in Ethiopia: A systematic review and meta-analysis

et al. 2023

View full text Add to dashboard Cite

Introduction Diabetic retinopathy (DR) is the primary retinal vascular complication of diabetes mellitus and a leading cause of visual impairment and blindness. It affects the global diabetic population. In Ethiopia, about one-fifth of diabetic patients were affected by DR, but there were inconsistent finding across studies about the determinants factors of DR. Therefore, we aimed to identify the risk factors for DR among diabetic patients. Methods We have accessed previous studies through an electronic web-based search strategy using PubMed, Google (Scholar), the Web of Science, and the Cochrane Library with a combination of search terms. The quality of each included article was assessed using the Newcastle Ottawa Assessment Scale. All statistical analyses were carried out using Stata version 14 software. The odds ratios of risk factors were pooled using a fixed-effect meta-analysis model. Heterogeneity was assessed using the Cochrane Q statistics and I-Square (I2). Furthermore, publication bias was detected based on the graphic asymmetry test of the funnel plot and/or Egger’s test (p< 0.05). Results The search strategy retrieved 1285 articles. After the removal of duplicate articles, 249 articles remained. Following further screening, about 18 articles were assessed for eligibility, of which three articles were excluded because of reporting without the outcome of interest, poor quality, and not full text. Finally, fifteen studies were reviewed for the final analysis. Co-morbid hypertension (HTN) (AOR 2.04, 95%CI: 1.07, 3.89), poor glycemic control (AOR = 4.36, 95%CI: 1.47, 12.90), and duration of diabetes illness (AOR = 3.83, 95%CI: 1.17, 12.55) were found to be confirmed associated factors of diabetic retinopathy. Conclusion In this study, co-morbid HTN, poor glycemic control, and longer duration of diabetes illness were found to be the determinant factors of DR. Aggressive treatment of co-morbid HTN and blood glucose, and regular eye screening should be implemented to reduce the occurrence of DR. Trial registration The review protocol was registered in the international prospective register of systematic reviews (PROSPERO) with registration number PROSPERO: CRD42023416724.

show abstract

Retinopathy among Adult Diabetics and Its Predictors in Northwest Ethiopia

Cited by 6 publications

References 27 publications

Visual impairment among diabetes patients in Ethiopia: A systematic review and meta-analysis

Visual impairment among diabetes patients in Ethiopia: A systematic review and meta-analysis

Incidence of Diabetic Retinopathy and Predictors among Adult Diabetic Patients in Central and Southern Ethiopia: A Multicentre Retrospective Cohort Study.

Determinants of diabetic retinopathy in Ethiopia: A systematic review and meta-analysis

Contact Info

Product

Resources

About