Retinopathy after Irradiation and Hyperbaric Oxygen

Stanford, Miles

doi:10.1177/014107688407701211

Cited by 13 publications

(2 citation statements)

References 9 publications

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“…The treatment of radiation retinopathy also remains limited and is a serious challenge for modern medicine. Photodynamic therapy, laser photocoagulation, oral pentoxifylline, intravitreal steroid therapy, and hyperbaric oxygen have inconclusive results and limited efficacy [99][100][101][102][103][104][105][106][107][108][109][110][111][112]. Anti-vascular endothelial growth factor agents (anti-VEGF agents) reduce vascular permeability and inhibit the formation of abnormal new vessels.…”

Section: Prevention and Treatmentmentioning

confidence: 99%

Radiation-induced eye impairments

Hristov

2024

IJCCR

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The problem of the impact of ionizing radiation on eye structures is one of the most important and topical in radiobiology. Knowledge of tissue radiosensitivity and induced tissue changes in the eye is essential for understanding the nature of radiation damage and the behavior of medical professionals. In this publication, the early and late determined radiation-induced impairments of the eye are presented as a result of radiotherapy or radiation incidents. The risk factors determining post-irradiation eye reactions, pathophysiological mechanisms, clinical picture, diagnosis, prevention, and new approaches in therapy are presented. We found that the typically found radiation-induced eye impairments are those of the eyelids – dermatosis and madarosis, conjunctiva – acute conjunctivitis, varied damage to the lacrimal apparatus, cornea – edema and ulceration, iris – rarely inflammation or neovascularization, sclera – rarely atrophy or necrosis, eye lens – cataract, retina – characteristic retinopathy, and optical nerve – rarely neuropathy. We provide the current consensus on prevention and treatment protocols in radiation-induced eye impairments, though most suggested treatment so far should qualify as experimental.

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Section: Prevention and Treatmentmentioning

confidence: 99%

Radiation-induced eye impairments

Hristov

2024

IJCCR

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“… 11 Attempts have been made in the past to treat radiation retinopathy with laser photocoagulation, hyperbaric oxygen therapy, pentoxifylline therapy, and photodynamic therapy. 12 , 13 , 14 Vascular endothelial growth factor (VEGF) and other inflammatory and vasculogenic factors play a role in the pathogenesis of macular edema and neovascularization. 15 For this reason, the use of anti-VEGF agents has come to the fore in the treatment of radiation-related macular edema, neovascularization, and papillopathy.…”

Section: Introductionmentioning

confidence: 99%

Early Results of Stereotactic Radiosurgery in Uveal Melanoma and Risk Factors for Radiation Retinopathy

Özcan¹,

Gündüz²,

Mirzayev³

et al. 2020

tjo

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Objectives: To report treatment results and complications of stereotactic radiosurgery in uveal malignant melanoma and to identify risk factors for development of radiation retinopathy. Materials and Methods: This was a retrospective study of 36 patients diagnosed with uveal melanoma between 2014 and 2019. Best corrected visual acuity, funduscopic findings, basal tumor diameter and tumor thickness were recorded at baseline and at follow-up visits at 3-month intervals. The response of tumors to stereotactic radiosurgery and complications were determined. Results: The mean basal diameter of tumor was 10.2 (range: 4.0-19.4, standard deviation [SD]: ±3.3) mm x 9.7 (range: 4.5-18.0, SD: ±3.3), tumor thickness was 5.1 (range: 2.0-11.0, ±2.4) mm at baseline. The mean follow-up period was 17.2 (range: 6-48, SD: ±10.43) months. The mean visual acuity was 0.5 (SD: ±0.3) logMAR before treatment and 0.6 (SD: ±0.3) logMAR after the mean follow-up period. The most common complications after stereotactic radiosurgery were cataract (38.9%) and radiation retinopathy (27.7%). There was a statistically significant relation between radiation retinopathy development and tumor distance from the optic disc (p=0.04). The rate of eye salvage was 83.3% in this study. Conclusion: Our short-term results show stereotactic radiosurgery was an effective and sustained treatment modality among the other eye conservation therapies.

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