Retinol binding protein in serum and in urine of glomerular and tubular nephropathies

Scarpioni, L; Dall'Aglio, P; Poisetti, Piergiorgio; Buzio, Carlo

doi:10.1016/0009-8981(76)90409-5

Cited by 38 publications

(19 citation statements)

References 18 publications

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“…The inverse relationship between LMW protein excretion and GFR that we have demonstrated in children with glomerular disease is similar to that reported previously in adults [30,31], and also to that observed in children with other diseases, including reflux nephropathy [32]. At levels of GFR less than 30 ml/min per 1.73 m 2 , elevated LMW protein excretion may be due to a renal tubular threshold being exceeded [33], but this would account for only a small percentage of the elevated LMW protein values.…”

Section: Discussionsupporting

confidence: 90%

Low molecular weight protein excretion in glomerular disease: a comparative analysis

Tomlinson

Dalton

Hartley

et al. 1997

Pediatric Nephrology

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We studied 23 children with steroid-sensitive nephrotic syndrome (SSNS), 21 children with steroid-resistant types of nephrotic syndrome and 32 children with other types of nephritis. Our controls were 43 apparently healthy children. We measured the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and the low molecular weight (LMW) protein beta 2-microglobulin (B2M), retinol-binding protein (RBP), alpha 1-microglobulin (A1M) and urine protein 1 (UP1). Results for B2M were considered only for a urine pH greater than 6.0. Comparisons were made with urine albumin excretion, glomerular filtration rate (GFR) and tubular abnormalities in selected renal biopsy samples. We found that abnormalities of LMW protein excretion occurred in between 50% (B2M) and 88% (UP1) of all subjects. In children with SSNS, A1M (r = 0.73), UP1 (r = 0.65) and NAG (r = 0.54) excretion were significantly correlated with albumin excretion, but not RBP or B2M excretion. Increased fractional excretion of A1M, B2M and UP1 and increased plasma A1M were demonstrated in 9 children with SSNS, suggesting competition for tubular reabsorption with albumin, most marked for UP1. In the steroid-resistant nephrotic and nephritic syndromes, correlation with albumin was found for all proteins. In these subjects, RBP (r = 0.37), B2M (r = 0.42) and A1M (r = 0.28) were inversely correlated with GFR, but not UP1, NAG or albumin. We found that RBP excretion was significantly greater in the presence of severe tubular abnormalities in 11 children with recent renal biopsies, but not A1M, UP1 or NAG. We conclude that LMW proteinuria is common in children with glomerular disease, and does not necessarily imply a poor prognosis. Factors other than histologically proven tubular abnormality may account for elevated LMW protein excretion. RBP is the LMW protein most closely associated with structural abnormality and least affected by increasing albuminuria.

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Section: Discussionsupporting

confidence: 90%

Low molecular weight protein excretion in glomerular disease: a comparative analysis

Tomlinson

Dalton

Hartley

et al. 1997

Pediatric Nephrology

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“…Tubular proteinuria in reflux nephropathy negatively correlates with GFR [2,7] and hence may be an unreliable marker of tubular function in the presence of advanced renal insufficiency, since urinary RBP increases due to spill over, and urinary NAG increases possibly as a result of altered urine creatinine excretion [27][28][29][30]. This would not have affected the results of this study as: (1) none of the subjects had advanced renal insufficiency and (2) there was no correlation between GFR and excretion of tubular proteins.…”

Section: Discussionmentioning

confidence: 99%

Tubular proteinuria in reflux nephropathy: post ureteric re-implantation

1996

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We studied urine protein excretion in 55 adults with reflux nephropathy (median age 26.9 years) who had had normal blood pressure, renal function and ureteric reimplantation in childhood. Urine retinol binding protein (RBP), N-acetyl-beta-D-glucosaminidase (NAG), albumin, bacteriuria, systolic blood pressure, glomerular filtration rate (GFR), peripheral plasma renin activity (PRA) and the degree of renal scarring were measured in each subject; 20 had bilateral and 35 unilateral renal scarring; 5 were hypertensive and none were in renal failure. Urinary NAG and RBP excretions were significantly greater in the study group than in 34 healthy controls (median age 29.7 years). Within the study group, NAG excretion significantly correlated with PRA (P = 0.02). RBP excretion correlated with PRA, systolic blood pressure and the laterality (bilateral vs. unilateral) of scarring (P < 0.01). Urinary albumin excretion correlated with systolic blood pressure (P = 0.03). We conclude that increased urinary protein, especially NAG and RBP excretion, occur late after ureteric re-implantation in reflux nephropathy independent of GFR. Its association with PRA supports the concept of segmental perfusion and filtration as an important mechanism that may explain the above findings.

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“…Retinol is transported to target tissues by plasma RBP [4], A limited literature exists describing the effects of a variety of diseases on the plasma level of RBP. Low levels of RBP have been reported in acute and chronic diseases of the liver [5] and kidney involving tubular and glomerular dysfunction [6,7). Recently, Basu et al [8] and Fabris et al [9] reported low levels of RBP in patients with cancer of epithelial origin at various sites.…”

Section: Discussionmentioning

confidence: 99%

Plasma Retinol-Binding Protein in Human Uterine Cervical Dysplasias and Cancer

Palan¹,

Basu²,

Romney³

1989

Gynecol Obstet Invest

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Plasma concentrations of retinol-binding protein (RBP) were measured in a cross-sectional study of asymptomatic normal menstruating women (n = 94) who obtained Pap smears and participated in a double-blinded nutritional survey. Controls (n = 45) were women with negative cervical cytology, normal colposcopy and no known gynecologic pathology or dysfunction. Cases (n = 49) were subjects with abnormal cytology and colposcopically directed biopsy that established cervical epithelial dysplasias histopathologically in the previous 12-month period. In addition, 8 women with cancer of the cervix were also investigated. The mean plasma concentration of RBP was significantly lower in cases than in controls (p < 0.001). In normal females, the follicular phase of the menstrual cycle was increased. This increase was absent in the plasma of patients with cervical dysplasias (p < 0.05). The data direct attention to a possible etiologic association between RBP in human cervical epithelial abnormalities and cancer.

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Retinol binding protein in serum and in urine of glomerular and tubular nephropathies

Cited by 38 publications

References 18 publications

Low molecular weight protein excretion in glomerular disease: a comparative analysis

Low molecular weight protein excretion in glomerular disease: a comparative analysis

Tubular proteinuria in reflux nephropathy: post ureteric re-implantation

Plasma Retinol-Binding Protein in Human Uterine Cervical Dysplasias and Cancer

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