Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin

Hu, Chunyan; Keen, Henry L.; Lu, Ko‐Ting; Liu, Xuebo; Wu, Jing; Davis, Deborah R.; Ibeawuchi, Stella‐Rita; Vogel, Silke; Quelle, Frederick W.; Sigmund, Curt D.

doi:10.1172/jci.insight.91738

Cited by 33 publications

(41 citation statements)

References 55 publications

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“…Although first reported to be expressed in adipocytes, analysis of mice carrying a LacZ knockin to the RBP7 gene locus suggested that expression of RBP7 was essentially endothelial specific (12). Similarly, we confirmed that RBP7 is expressed in the endothelial cell (CD31 and NOS3 positive) fraction of kidney, lung and aorta (25).…”

Section: The Functional Link Between Pparγ and Rbp7supporting

confidence: 82%

“…We first examined vascular function in RBP7-deficient mice to determine if, like PPARγ, RBP7 plays a role in regulating endothelial function. Although the RBP7deficient mouse model is a global knockout, the endothelial specificity of RBP7 expression suggests that functionally the model acts as an endothelial-specific knockout (12,25). We showed that under baseline conditions endothelial-dependent vasodilation was normal in RBP7-deficient mice.…”

Section: The Functional Link Between Pparγ and Rbp7mentioning

confidence: 72%

“…Many laboratories, including ours, have examined the concept that the beneficial blood pressure lowering effects of PPARγ activation are due to its activity in vascular smooth muscle (24, 50) and endothelium (8,26,31,48). In some cases, the downstream PPARγ target genes and pathways have been identified (1,25,28). Our studies revealed that PPARγ target genes are different in smooth muscle and endothelium (11,(33)(34)(35).…”

Section: Pparγ and Cardiovascular Regulationmentioning

confidence: 99%

“…RBP7 is a PPARγ target gene reported to play a role in lipid dynamics and whole body energy metabolism (65), and was shown to be a target of PPARγ regulation in vascular tissue (25). Although first reported to be expressed in adipocytes, analysis of mice carrying a LacZ knockin to the RBP7 gene locus suggested that expression of RBP7 was essentially endothelial specific (12).…”

Section: The Functional Link Between Pparγ and Rbp7mentioning

confidence: 99%

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Role of PPARγ and retinol binding protein 7 in the vascular endothelium

Woll¹

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the opportunity to conduct research in his laboratory and his mentorship early in my professional development. I would like to acknowledge the funding agencies that made this work possible, including the National Institutes of Health and the American Heart Association. I would thank Dr. Sherree Wilson for her exceptional mentorship throughout my graduate career. I would also like to thank Drs. Lois Geist and Denise Martinez for their insights and support. I would like to thank the staff of the Office of Cultural Affairs and Diversity Initiatives in the Carver College of Medicine for their support of myself and the student organization, Association of Multicultural Scientists.

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Section: The Functional Link Between Pparγ and Rbp7supporting

confidence: 82%

Section: The Functional Link Between Pparγ and Rbp7mentioning

confidence: 72%

Section: Pparγ and Cardiovascular Regulationmentioning

confidence: 99%

Section: The Functional Link Between Pparγ and Rbp7mentioning

confidence: 99%

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Role of PPARγ and retinol binding protein 7 in the vascular endothelium

Woll¹

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“…Cerebral basilar arteries were cannulated onto glass pipettes and pressurized at 60 mmHg, and vascular reactivity experiments were conducted using a Danish Myograph Technology (DMT) system as previously reported (11,16,24,58,59). Mice were euthanized as described above, and the basilar arteries were isolated, cleaned of connective tissues, and cannulated onto glass pipettes filled with oxygenated Krebs buffer in an organ chamber.…”

Section: Methodsmentioning

confidence: 99%

Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension

Agbor¹,

Nair²,

Wu³

et al. 2019

JCI Insight

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Spatiotemporal analysis of human intestinal development at single-cell resolution

Fawkner-Corbett

Antanaviciute

Parikh

et al. 2021

Cell

327

305

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Summary Development of the human intestine is not well understood. Here, we link single-cell RNA sequencing and spatial transcriptomics to characterize intestinal morphogenesis through time. We identify 101 cell states including epithelial and mesenchymal progenitor populations and programs linked to key morphogenetic milestones. We describe principles of crypt-villus axis formation; neural, vascular, mesenchymal morphogenesis, and immune population of the developing gut. We identify the differentiation hierarchies of developing fibroblast and myofibroblast subtypes and describe diverse functions for these including as vascular niche cells. We pinpoint the origins of Peyer’s patches and gut-associated lymphoid tissue (GALT) and describe location-specific immune programs. We use our resource to present an unbiased analysis of morphogen gradients that direct sequential waves of cellular differentiation and define cells and locations linked to rare developmental intestinal disorders. We compile a publicly available online resource, spatio-temporal analysis resource of fetal intestinal development (STAR-FINDer), to facilitate further work.

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Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin

Cited by 33 publications

References 55 publications

Role of PPARγ and retinol binding protein 7 in the vascular endothelium

Role of PPARγ and retinol binding protein 7 in the vascular endothelium

Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension

Spatiotemporal analysis of human intestinal development at single-cell resolution

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