Retinol Binding Protein-4 Levels and Clinical Features of Type 2 Diabetes Patients

Takebayashi, Kohzo; Suetsugu, Mariko; Wakabayashi, Shigeo; Aso, Yoshimasa; Iwamoto, Toshihiko

doi:10.1210/jc.2006-1249

Cited by 185 publications

(206 citation statements)

References 23 publications

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“…Cho et al (6) found significantly different RBP-4 levels between patients with normal glucose tolerance on one hand and IGT and diabetes on the other hand. A similar increase in serum RBP-4 concentrations in diabetic subjects is observed in an independent study (25). Different patient characteristics might explain the differences observed in the association between RBP-4 and metabolic parameters.…”

Section: Univariate and Multivariate Correlationssupporting

confidence: 83%

Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

et al. 2007

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OBJECTIVE -Retinol-binding protein (RBP)-4 was recently identified as an adipokine that induces insulin resistance. In the current study, we investigated RBP-4 serum levels in diabetic and nondiabetic patients on chronic hemodialysis (CD) compared with control subjects with a glomerular filtration rate Ͼ50 ml/min. The majority of the diabetic subjects used oral hypoglycemic agents or insulin.RESEARCH DESIGN AND METHODS -RBP-4 was determined by enzyme-linked immunosorbent assay in control subjects (n ϭ 59) and CD patients (n ϭ 58) and correlated with clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups.RESULTS -Mean serum RBP-4 levels were almost fourfold higher in CD patients (102 Ϯ 30 mg/l) compared with control subjects (28 Ϯ 8 mg/l). Furthermore, serum creatinine independently predicted RBP-4 concentrations in multiple regression analyses in both control subjects and CD patients. In addition, C-reactive protein and systolic blood pressure independently and negatively correlated with RBP-4 serum concentrations in CD patients but not control subjects. In contrast, markers of glucose and lipid metabolism were not independently related to serum RBP-4 in control subjects or CD patients.CONCLUSIONS -We show that markers of renal function are independently related to serum RBP-4 levels.

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Section: Univariate and Multivariate Correlationssupporting

confidence: 83%

Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

et al. 2007

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“…On the contrary, higher levels of circulating RBP4 are described in men (35,37,65,67,72). This dimorphism was, however, not shown in all studies (32,73,84,85). Recently, higher RBP4 mRNA expression in adipose tissue was found in women when compared with men; this was, however, not reflected in the circulating levels (73).…”

Section: Sex-specific Dimorphism Of Rbp4mentioning

confidence: 88%

RBP4: a controversial adipokine

Kotnik

Fischer‐Posovszky

Wabitsch

2011

European Journal of Endocrinology

210

165

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Adipose tissue is an endocrine organ secreting biologically active factors called adipokines that act on both local and distant tissues. Adipokines have an important role in the development of obesity-related comorbidities not only in adults but also in children and adolescents. Retinol binding protein 4 (RBP4) is a recently identified adipokine suggested to link obesity with its comorbidities, especially insulin resistance, type 2 diabetes (T2D), and certain components of the metabolic syndrome. However, data, especially resulting from the clinical studies, are conflicting. In this review, we summarize up-to-date knowledge on RBP4's role in obesity, development of insulin resistance, and T2D. Special attention is given to studies on children and adolescents. We also discuss the role of possible confounding factors that should be taken into account when critically evaluating published studies or planning new studies on this exciting adipokine.

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“…They showed that serum RBP4 levels were elevated in GLUT4 glucose transporter knockout mice and humans with obesity and type 2 diabetes [11]. Currently, increasing evidence denotes an association between increased circulating levels of RBP4 with type 2 diabetes mellitus and/or insulin resistance states [11,25,12,[26][27][28][29][30][31]. A pathophysiological link between RBP4 and type 2 diabetes mellitus may also arise from impaired insulin secretion [3].…”

Section: Discussionmentioning

confidence: 99%

The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels

Akbarzadeh¹,

Nabipour²,

Assadi³

et al. 2012

Cytokine

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a b s t r a c tObjective: It has been suggested that adipose-derived cytokines act as insulin sensitizers/insulin-mimetics and some others may induce insulin resistance. In order to elucidate the potential role of novel adipocytokines in the pre-diabetes states, circulating levels of novel adipocytokines were evaluated in first-degree relatives of subjects with type 2 diabetes mellitus (FDRs). Method: Serum omentin-1, adiponectin and retinol-binding protein 4 (RBP4) levels were measured in 179 subjects (90 glucose tolerant FDRs and 89 age-and sex-matched healthy controls) using enzymelinked immunosorbent assay (ELISA) methods. Results: There was no significant difference between the two groups regarding serum RBP4 concentrations. However, serum omentin-1 (median [interquartile range], 6.18 [4.06-11.52] ng/ml versus 10.50 [4.30-20.60] ng/ml, p = 0.004) and adiponectin (mean ± SD, 10.07 ± 4.0 lg/ml versus 20.66 ± 8.12 lg/ml, p < 0.0001) levels were significantly lower in FDRs when compared with the controls. In multiple logistic regression analysis, FDRs showed a significant association with lower circulating omentin-1 and adiponectin levels, even after adjustments were made for age, sex, body mass index, blood pressure measures, and biochemical parameters including glucose status, lipid profile, insulin levels and HOMA-IR (OR = 0.49, p = 0.004 and OR = 0.74,; p < 0.0001, respectively). However, FDRs did not show a significant association with serum RBP4 levels in different models of regression analyses. Conclusions: The FDRs showed significant associations with lower omentin-1 and adiponectin levels. A potential role for these adipokines in the FDRs' increased risk of diabetes needs to be further elucidated.

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Retinol Binding Protein-4 Levels and Clinical Features of Type 2 Diabetes Patients

Abstract: The current study shows that RBP4 is associated with variables related to insulin resistance and diabetic complications. The addition of pioglitazone for 12 wk to other diabetic medications the patients were already taking did not affect serum RBP4 levels.

Cited by 185 publications

References 23 publications

Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

RBP4: a controversial adipokine

The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels

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