Retinol-binding protein 4 is not associated with insulin resistance in pregnancy

Khovidhunkit, Weerapan; Pruksakorn, Promphan; Plengpanich, Wanee; Tharavanij, Thipaporn

doi:10.1016/j.metabol.2011.05.019

Cited by 28 publications

(26 citation statements)

References 16 publications

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“…Furthermore, consistent with our findings, previous studies confirmed that patients with GDM had higher median plasma concentration of RBP4 than normal pregnant women [1,12,22,[34][35][36]. However, other studies found that there were no significant differences in serum RBP4 between the controls and those that developed GDM group [14,37,38]. Furthermore, another study showed that women with GDM had lower RBP4 EIA and western blot levels than controls (p < 0.001 and p = 0.026) [39].…”

Section: Discussionsupporting

confidence: 90%

A Prospective Study of Maternal Plasma Concentrations of Retinol-Binding Protein 4 and Risk of Gestational Diabetes Mellitus

Du¹,

Kong²

2018

Ann Nutr Metab

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Background: The aim of this study was to investigate whether retinol-binding protein 4 (RBP4) concentrations, measured at the first prenatal visit, are associated with risk of gestational diabetes mellitus (GDM). Methods: From July 2015 to June 2016, consecutive women who admitted to the obstetrics center of our hospital were included. At the first prenatal visit (the median gestational age was 6 [interquartile range 4–10] weeks) in the hospital, involved subjects were tested for fasting plasma glucose (FPG) and RBP4 using venous plasma samples collected after at least 8 h of fasting in the morning. Data for FPG and RBP4 concentrations at the first prenatal visit and one-step GDM screening with 75-g oral glucose tolerance test performed between 24 and 28 weeks of gestation were collected and analyzed. Results: Blood at first prenatal visit was available for 827 women, among whom GDM developed in 101 (12.2%). In multivariate models comparing the second (Q2), third, and fourth quartiles against the first quartile of RBP4, concentrations of RBP4 in Q2, Q3, and Q4 were associated with GDM later developed, and increased risk of GDM by 54, 205, and 536%. There was a significant statistical difference in the area under the curve between the established risk factors alone and the addition of RBP4 concentrations (difference, 0.039 [95% CI 0.030–0.052]; p = 0.03). In the subgroup of women combined with obesity and FABP4 ≥median, the measured OR was 9.83 (95% CI [4.76–16.13]; p < 0.001) for GDM compared to those without obesity and FABP4

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Section: Discussionsupporting

confidence: 90%

A Prospective Study of Maternal Plasma Concentrations of Retinol-Binding Protein 4 and Risk of Gestational Diabetes Mellitus

Du¹,

Kong²

2018

Ann Nutr Metab

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“…In that study, overweight mothers had higher RBP4 levels and this suggested an association related to maternal adipose tissue mass, rather than glucose metabolism. In our study, maternal RBP4 levels correlated with TG levels, an indicator of maternal adipose tissue mass, but did not correlate with the markers of insulin resistance, this was in accordance with a previous study [28].…”

Section: Retinol-binding Protein 4 Levels Are Related To Maternal Trisupporting

confidence: 93%

“…The only correlation was observed between maternal glucose and RBP4 levels in fetuses of the bottom quartile. Previously plasma RBP4 levels were found to increase with increasing TG levels [6,27,28]. On the contrary, in a recent study no association was reported between maternal RBP4 levels and prepregnancy BMI, birth weight, parameters of insulin resistance and TG levels [29].…”

Section: Retinol-binding Protein 4 Levels Are Related To Maternal Trimentioning

confidence: 87%

Clinical immunology Retinol-binding protein 4 levels are related to maternal triglyceride levels

Güdücü¹,

İşçi²,

Görmüş³

et al. 2013

cejoi

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“…There was no statistical difference between this group and the patients with diabetes in this study. Studies in pregnant women with gestational diabetes also found no change in serum retinol (Grissa et al 2007, Tepper et al 2010) nor in RBP4 (Khovidhunkit et al 2012).…”

Section: Discussionmentioning

confidence: 96%

Gestational diabetes: a risk of puerperal hypovitaminosis A?

Resende

Lira

Grilo

et al. 2015

An. Acad. Bras. Ciênc.

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The influence of gestational diabetes on vitamin A deficiency in lactating women and, consequently, in their newborn has been verified through a cross-sectional case-control study conducted with volunteer puerperal women. The control group consisted of healthy women and the test group was composed of women with gestational diabetes. One hundred and seven women were recruited, corresponding to 71 controls and 36 cases. Personal, gestational and newborn data were collected directly from medical records during hospitalization. The retinol was determined in maternal colostrum and serum by High Performance Liquid Chromatography. Postpartum women with gestational diabetes were older, had more children and a higher prevalence of cesarean delivery. No difference was found in retinol concentration in maternal milk and serum between the groups. However, it was observed that 16.7% had vitamin A deficiency in the group of patients with diabetes and only 4.1% had such deficiency in the control group. Although no difference was found in colostrum and serum retinol concentration between women with and without gestational diabetes, the individual analysis shows that those with diabetes are at higher risk of being vitamin A deficient.

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Retinol-binding protein 4 is not associated with insulin resistance in pregnancy

Cited by 28 publications

References 16 publications

A Prospective Study of Maternal Plasma Concentrations of Retinol-Binding Protein 4 and Risk of Gestational Diabetes Mellitus

A Prospective Study of Maternal Plasma Concentrations of Retinol-Binding Protein 4 and Risk of Gestational Diabetes Mellitus

Clinical immunology Retinol-binding protein 4 levels are related to maternal triglyceride levels

Gestational diabetes: a risk of puerperal hypovitaminosis A?

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