Retinol-Binding Protein 4 Is Associated with Insulin Resistance and Body Fat Distribution in Nonobese Subjects without Type 2 Diabetes

Gavi, Shai; Stuart, Louise; Kelly, Patricia J.; Meléndez, Mark M.; Mynarcik, Dennis C.; Gelato, Marie C.; McNurlan, Margaret A.

doi:10.1210/jc.2006-1815

Cited by 160 publications

(142 citation statements)

References 23 publications

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“…Stefan et al (22) convincingly demonstrated that circulating RBP-4 positively correlates with HOMA-IR in healthy subjects. A positive association between RBP-4 levels and insulin resistance is also shown in obese and nonobese adolescents (18); in subjects with obesity, IGT, or type 2 diabetes; in nonobese, nondiabetic subjects with a strong family history of type 2 diabetes (5); and in nonobese individuals without a family history or diagnosis of diabetes (23). In contrast, no correlation between RBP-4 and insulin resistance is found in Aboriginal Canadian women and white women (24).…”

Section: Univariate and Multivariate Correlationsmentioning

confidence: 94%

Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

et al. 2007

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OBJECTIVE -Retinol-binding protein (RBP)-4 was recently identified as an adipokine that induces insulin resistance. In the current study, we investigated RBP-4 serum levels in diabetic and nondiabetic patients on chronic hemodialysis (CD) compared with control subjects with a glomerular filtration rate Ͼ50 ml/min. The majority of the diabetic subjects used oral hypoglycemic agents or insulin.RESEARCH DESIGN AND METHODS -RBP-4 was determined by enzyme-linked immunosorbent assay in control subjects (n ϭ 59) and CD patients (n ϭ 58) and correlated with clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups.RESULTS -Mean serum RBP-4 levels were almost fourfold higher in CD patients (102 Ϯ 30 mg/l) compared with control subjects (28 Ϯ 8 mg/l). Furthermore, serum creatinine independently predicted RBP-4 concentrations in multiple regression analyses in both control subjects and CD patients. In addition, C-reactive protein and systolic blood pressure independently and negatively correlated with RBP-4 serum concentrations in CD patients but not control subjects. In contrast, markers of glucose and lipid metabolism were not independently related to serum RBP-4 in control subjects or CD patients.CONCLUSIONS -We show that markers of renal function are independently related to serum RBP-4 levels.

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Section: Univariate and Multivariate Correlationsmentioning

confidence: 94%

Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

et al. 2007

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“…For instance, plasma levels of retinol-binding protein 4, a protein released from adipocytes and associated with insulin resistance, 121 correlate with trunk fat mass. 122,123 Further, serum vaspin, an insulin-sensitizing adipokine, shows an interesting sexual dimorphism with levels higher in women. 124 For these, and for other emerging adipokines, little is known regarding the specific role of regional adipose tissue in their production, secretion and function in human metabolism.…”

Section: Other Adipokinesmentioning

confidence: 99%

Gluteofemoral body fat as a determinant of metabolic health

2010

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Body fat distribution is an important metabolic and cardiovascular risk factor, because the proportion of abdominal to gluteofemoral body fat correlates with obesity-associated diseases and mortality. Here, we review the evidence and possible mechanisms that support a specific protective role of gluteofemoral body fat. Population studies show that an increased gluteofemoral fat mass is independently associated with a protective lipid and glucose profile, as well as a decrease in cardiovascular and metabolic risk. Studies of adipose tissue physiology in vitro and in vivo confirm distinct properties of the gluteofemoral fat depot with regards to lipolysis and fatty acid uptake: in day-to-day metabolism it appears to be more passive than the abdominal depot and it exerts its protective properties by long-term fatty acid storage. Further, a beneficial adipokine profile is associated with gluteofemoral fat. Leptin and adiponectin levels are positively associated with gluteofemoral fat while the level of inflammatory cytokines is negatively associated. Finally, loss of gluteofemoral fat, as observed in Cushing's syndrome and lipodystrophy is associated with an increased metabolic and cardiovascular risk. This underlines gluteofemoral fat's role as a determinant of health by the long-term entrapment of excess fatty acids, thus protecting from the adverse effects associated with ectopic fat deposition.

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“…RBP4 is highly expressed in liver as well as adipose tissue, and its circulating levels have been shown to correlate with obesity and insulin resistance in rodents (Yang et al 2005). In humans, RBP4 levels have been shown to be elevated in several groups of insulin-resistant subjects (Graham et al 2006;Gavi et al 2007), but not all studies have shown such differences (Janke et al 2006;Takashima et al 2006). It has been suggested that increased serum RBP4 levels might contribute to insulin resistance by impairing insulin-stimulated glucose uptake in muscles and elevating hepatic glucose production, although the mechanism is not fully clear (Yang et al 2005).…”

Section: Adipokinesmentioning

confidence: 99%

Mechanisms of obesity-associated insulin resistance: many choices on the menu

Qatanani¹,

Lazar²

2007

Genes Dev.

659

502

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Obesity-associated insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. In the past decade, a large number of endocrine, inflammatory, neural, and cell-intrinsic pathways have been shown to be dysregulated in obesity. Although it is possible that one of these factors plays a dominant role, many of these factors are interdependent, and it is likely that their dynamic interplay underlies the pathophysiology of insulin resistance. Understanding the biology of these systems will inform the search for interventions that specifically prevent or treat insulin resistance and its associated pathologies.

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Retinol-Binding Protein 4 Is Associated with Insulin Resistance and Body Fat Distribution in Nonobese Subjects without Type 2 Diabetes

Abstract: These findings indicate a relationship between RBP4, insulin sensitivity, and percent trunk fat in individuals who may not have features of insulin resistance.

Cited by 160 publications

References 23 publications

Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

Gluteofemoral body fat as a determinant of metabolic health

Mechanisms of obesity-associated insulin resistance: many choices on the menu

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