Retinol binding protein 4 concentrations are influenced by renal function in patients with type 2 diabetes mellitus

Masaki, Takayuki; Anan, Futoshi; Tsubone, Tetsuo; Gotoh, Koro; Chiba, Seiichi; Katsuragi, Isao; Nawata, Tomoko; Kakuma, Tatsuyuki; Yoshimatsu, Hironobu

doi:10.1016/j.metabol.2008.03.013

Cited by 18 publications

(37 citation statements)

References 22 publications

(27 reference statements)

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“…, 2009; Murata et al. , 2009) were each measured in two of the selected studies, and creatinine concentrations were determined in three (Masaki et al. , 2008; Chen et al.…”

Section: Resultsmentioning

confidence: 99%

Association between serum retinol‐binding protein 4 concentrations and clinical indices in subjects with type 2 diabetes: a meta‐analysis

Park

Green

Shaffer

2012

J Human Nutrition Diet

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“…, 2009; Murata et al. , 2009) were each measured in two of the selected studies, and creatinine concentrations were determined in three (Masaki et al. , 2008; Chen et al.…”

Section: Resultsmentioning

confidence: 99%

Association between serum retinol‐binding protein 4 concentrations and clinical indices in subjects with type 2 diabetes: a meta‐analysis

Park

Green

Shaffer

2012

J Human Nutrition Diet

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“…There is a large body of data demonstrating that insulin resistance alters adipose and renal metabolism of RBP4 (retinol binding protein 4), which paradoxically further promotes insulin resistance and the pathogenesis of T2D (48,49). Testament to the growing interest in retinoids as metabolic modulating agents is the recent initiation of phase 2 clinical trials of the synthetic retinoid fenretinide 4-hydroxy(phenyl)retinamide as a novel antiobesity and insulin-sensitizing agent (50).…”

Section: Discussionmentioning

confidence: 99%

Vitamin A Deficiency Causes Hyperglycemia and Loss of Pancreatic β-Cell Mass

Trasino

Benoit

Gudas

2015

Journal of Biological Chemistry

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Background:Little is known about vitamin A (VA) regulation of pancreatic endocrine mass in adults. Results: Decreased pancreatic VA causes increased ␣-cell to ␤-cell mass ratios, hyperglycemia, and hyperglucagonemia. Reintroducing dietary VA restores normoglycemia and ␣-cell to ␤-cell mass. Conclusion: VA is essential for maintenance of ␤-cell functions in adult pancreas. Significance: VA therapies may potentially prevent ␤-cell apoptosis and loss in diabetes.

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“…In addition, it has been suggested that the increased RBP concentration observed in patients with type 2 DM may be due to impaired kidney function rather than the diabetic state itself[46, 67]. During normal pregnancy, the urinary excretion of RBP is greater than in the non-pregnant state, and increases from the first to the second and third trimester[7, 35].…”

Section: Discussionmentioning

confidence: 99%

Retinol binding protein 4 – a novel association with early-onset preeclampsia

Vaisbuch¹,

Romero²,

Mazaki‐Tovi³

et al. 2010

Journal of Perinatal Medicine

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Objective: Dysregulation of maternal circulating adipokines has been implicated in several ''great obstetrical syndromes'' including preeclampsia (PE), small-for-gestational age (SGA) neonate and fetal death (FD). It has been suggested that adipokines provide a molecular link between metabolic derangements and inflammatory response in complicated pregnancies. Retinol binding protein 4 (RBP4), a novel adipokine, plays a role in obesity-related disorders, as well as in the regulation of the immune response. The aim of this study was to determine whether there are changes in maternal plasma concentrations of RBP4 in patients with PE and in those with an SGA neonate or FD. Study design: This cross-sectional study included patients in the following groups: 1) normal pregnancy (ns134); 2) PE (ns104); 3) SGA neonate (ns28); and 4) FD (ns 37). Maternal plasma RBP4 concentrations were determined by ELISA. Non-parametric statistics were used for analysis. Results: 1) The median maternal plasma RBP4 concentration was higher among patients with PE than in those with a normal pregnancy (Ps0.03); 2) The median maternal plasma RBP4 concentrations of patients with preterm PE (-37 weeks) was higher than that of those with term PE (Ps0.017) and than that of those with a normal pregnancy (Ps0.002); 3) The median maternal plasma RBP4 concentration did not differ significantly between patients with a normal pregnancy and those with an SGA neonate or with an FD; 4) Among normal pregnant women, the maternal plasma RBP4 concentrations did not correlate with pre-pregnancy body mass index, gestational age at blood sampling and neonatal birthweight. Conclusions: 1) Preeclampsia, but not pregnancy with an SGA neonate or an FD, is associated with a higher median maternal plasma concentration of RBP4 than normal pregnancy; 2) Preterm PE, and specifically early-onset PE, is associated with higher median RBP4 concentrations in maternal plasma compared to term PE. These findings suggest a role for RBP4 in the pathogenesis of preterm PE, but not in SGA and FD.

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Retinol binding protein 4 concentrations are influenced by renal function in patients with type 2 diabetes mellitus

Cited by 18 publications

References 22 publications

Association between serum retinol‐binding protein 4 concentrations and clinical indices in subjects with type 2 diabetes: a meta‐analysis

Association between serum retinol‐binding protein 4 concentrations and clinical indices in subjects with type 2 diabetes: a meta‐analysis

Vitamin A Deficiency Causes Hyperglycemia and Loss of Pancreatic β-Cell Mass

Retinol binding protein 4 – a novel association with early-onset preeclampsia

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