Retinol‐binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes

Cabré, Anna; Lázaro, Iolanda; Girona, Josefa; Manzanares, José María; Marimón, Francesc; Plana, Núria; Heras, Mercedes; Masana, Luís

doi:10.1111/j.1365-2796.2007.01849.x

Cited by 109 publications

(108 citation statements)

References 25 publications

(33 reference statements)

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“…Increased serum RBP4 levels are reportedly associated with body mass index, waist circumference, and insulin resistance (Yang et al, 2005;Graham et al, 2006;Cabré et al, 2007). We observed that serum RBP4 concentrations decreased rapidly as early as 1 day after kidney transplantation.…”

Section: Discussionmentioning

confidence: 53%

Decreased retinol-binding protein 4 in the sera of patients with end-stage renal disease after kidney transplantation

Zhang¹,

Zhou²,

Zhang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Retinol-binding protein 4 (RBP4) is a novel adipokine that has been associated with insulin resistance and type 2 diabetes. Patients with end-stage renal disease (ESRD) have very high serum RBP4 levels. However, whether successful kidney transplantation alleviates these elevated serum RBP4 levels is unclear. The serum RBP4 levels of 24 ESRD patients were determined before transplantation and at 1 day, 1 week, and 1 month after kidney transplantation. The control group included 22 healthy subjects. Serum RBP4 concentrations were measured using a commercial kit via the immunologic turbidimetric method, and were related to biomarkers for renal and liver function. The serum RBP4 level of ESRD patients before kidney transplantation (160.8 ± 29.1 mg/L) was Level of RBP4 in patients after kidney transplantation approximately 7-fold higher than that of normal controls (22.6 ± 11.0 mg/L; P = 0.000). The serum RBP4 level before transplantation was significantly higher than that at 1 day (65.3 ± 28.4 mg/L), 1 week (48.3 ± 22.9 mg/L), and 1 month after transplantation (53.1 ± 25.5 mg/L; P = 0.000). However, these values were still higher than those of controls (P = 0.000). Univariate regression analysis showed that the percent changes in serum RBP4 concentration before and after kidney transplantation were positively correlated with serum creatinine, blood urea nitrogen, phosphate, and pre-albumin concentrations and negatively correlated with the estimated glomerular filtration rate. The serum RBP4 concentration of patients with ESRD decreased significantly after kidney transplantation; therefore, we found that serum RBP4 concentration was related to renal function.

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Section: Discussionmentioning

confidence: 53%

Decreased retinol-binding protein 4 in the sera of patients with end-stage renal disease after kidney transplantation

Zhang¹,

Zhou²,

Zhang³

et al. 2014

Genet. Mol. Res.

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“…However, there are several controversial results regarding insulin resistance [8][9][10][11][12][13]. In diabetic nephropathy plasma RBP4 levels are further elevated in diabetic subjects with microalbuminuria [14][15][16].…”

mentioning

confidence: 99%

An Increase in Serum Retinol-Binding Protein 4 in the Type 2 Diabetic Subjects with Nephropathy

et al. 2009

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Abstract. The present study was undertaken to determine retinol-binding protein 4 (RBP4) levels in subjects with diabetic nephropathy. A total of 149 type 2 diabetic subjects and 19 control subjects were enrolled. Serum levels of RBP4 were measured by a method of ELISA. Serum RBP4 levels were significantly greater in the subjects with type 2 diabetes mellitus than the controls (70.5 ± 35.3 vs. 40.1 ± 13.0 µg/ml, mean ± SD, p<0.01). Serum RBP4 levels were gradually increased according to the progression of diabetic nephropathy (p value in trend test: <0.001). Its elevation was significantly greater in the diabetic subjects with stages 1, 3B and 4 than the control subjects (Stage 1: 64.6 ± 29.7, Stage 3B: 123.3 ± 71.8, Stage 4: 91.4 ± 33.8 vs. Control: 40.1 ± 13.0 µg/ml, p<0.01). Similar results were obtained in the subjects based on the amount of albuminuria (Normo-: 64.6 ± 29.7, Micro-: 63.7 ± 29.4, and Marcoalbuminuria: 90.3 ± 44.6 µg/ml, p <0.001). Serum RBP4 levels had a positive correlation with serum creatinine levels(r = 0.377, p<0.001), and a negative correlation with 1/creatinine (r = -0.420, p<0.001). Also, there was a negative correlation between serum RBP4 and the estimated glomerular filtration rate(r = -0.436, p<0.001). Multiple regression analysis showed that estimated glomerular filtration rate was an independent determinant for increased serum RBP4 levels. There was no difference in serum RBP4 levels between the advanced nephropathy with and without macrovascular diseases. These results indicate an increase in serum RBP4 levels in the type 2 diabetic subjects, particularly complicated with advanced renal impairment.

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“…Among them, there was significant deviation of five proteins [β-2-microglobulin, annexin A1, complement C5, retinol-binding protein 4 (RBP4) and argininosuccinate synthase], which are known to potentially participate in IgAN and certain glomerular diseases (15)(16)(17)(18). The present study provides additional evidence that iTRAQ technology accurately quantifies the relative changes in the protein abundance of renal tissue.…”

Section: Discussionmentioning

confidence: 68%

Comparative proteomic analysis of renal tissue in IgA nephropathy with iTRAQ quantitative proteomics

et al. 2014

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Abstract. Immunoglobulin (Ig) A nephropathy (IgAN) is the most common form of glomerulonephritis. In clinical practice, it is difficult to monitor the repeating relapse in patients suffering from IgAN, which usually occurs within 10 years of end-stage renal disease. In order to identify and quantify the total protein content in the renal tissue of patients with IgAN, isobaric tags for relative and absolute quantification (iTRAQ) technology was performed. iTRAQ coupled with multiple chromatographic fractionation and tandem mass spectrometry was used to analyze the total protein of normal renal tissue in IgAN and healthy patients. The individual proteins were identified by the Mascot search engine and any that were differentially expressed were monitored. A total of 574 different proteins were identified, and 287 proteins were up-or downregulated by >1 fold alteration in levels. The results showed that iTRAQ-based quantitative proteomic technology for the identification and relative quantitation of the renal tissue proteome is efficiently applicable. The differential expression of the proteome profiles for IgAN patients was determined. Further studies using large cohorts of patient samples with long-term clinical follow-up data should be conducted to evaluate the usefulness of the pathogenesis and novel biomarker candidates of IgAN, which may develop a novel technique for the diagnosis of IgAN.

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Retinol‐binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes

Cited by 109 publications

References 25 publications

Decreased retinol-binding protein 4 in the sera of patients with end-stage renal disease after kidney transplantation

Decreased retinol-binding protein 4 in the sera of patients with end-stage renal disease after kidney transplantation

An Increase in Serum Retinol-Binding Protein 4 in the Type 2 Diabetic Subjects with Nephropathy

Comparative proteomic analysis of renal tissue in IgA nephropathy with iTRAQ quantitative proteomics

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