Retinoids, urinary bladder carcinogenesis, and chemoprevention: A review and synthesis

Abstract

An analysis of the effects of natural (vitamin A) and synthetic retinoids on experimental carcinogenesis of the urinary bladder indicates that inhibitory activity is carcinogen- or carcinogen-class-specific. These findings suggest that there may be more than one pathway for the neo-differentiation of urothelial cells to frank carcinoma and that these pathways may be related to both carcinogen class and dietary vitamin A status.

Diet and Chemoprevention in NCI's Research Strategy to Achieve National Cancer Control Objectives

“…Subsequently, other research showed that retinoic acid inhibits the develop ment of bladder tumors (4), mammary tumors (68,69,70), and skin cancer in mice (8). Animal studies clearly established the important principles that the effectiveness of a retinoid as a chemopreventive agent varies with the particular retinoid, the dose of the retinoid, the cancer-producing agent or carcinogen, the type of cancer, and the animal being studied (29,44). was approximately double that of the highest intake group.…”

Influence of Retinoids on Bladder Cancer Growth as Detected by Primary Tissue Culture

“…Since retinoids are involved in the induction or enhancement of cellular differentiation, they may also be able to prevent or reverse the process of carcinogenesis by modulation of the mechanism involved in differentiation (Moon et al, 1983). The ability of retinoid compounds to inhibit or delay the appearance of human superficial bladder cancers (Alfthan er al., 1983) and carcinogen-induced animal bladder cancers has been well documented (Lower and Kanarek, 1981). These effects of retinoids on tumour cells prompted us to study the ability of 13-cis and all-trans retinoic acid to inhibit the growth of human bladder cancer cells in primary tissue culture.…”