Retinoids

Saurat, Jean‐Hilaire; Sorg, Olivier

doi:10.1007/978-3-662-45139-7_147

Cited by 2 publications

(1 citation statement)

References 73 publications

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“…The concept of cumulative dose (mg/kg bodyweight), introduced by Harms in 1989, is the total amount of oral isotretinoin taken by the patient over the entire duration, divided by the bodyweight 31,32 . According to the EMA, a treatment course of 16–24 weeks is normally sufficient to achieve remission and it is mentioned that no substantial additional benefit is to be expected beyond a cumulative treatment dose of 120–150 mg/kg 2…”

Section: Clinical Question 4: Is a Cumulative Dose Necessary?mentioning

confidence: 99%

Comparison of guidelines and consensus articles on the management of patients with acne with oral isotretinoin

Dessinioti

Zouboulis

Bettoli

et al. 2020

Acad Dermatol Venereol

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Guidelines and consensus on the management of patients with acne aim to give evidence-based, expert-group recommendations. This review compares current guidelines and consensus articles to provide a compilation of recommendations on the treatment of acne with oral isotretinoin. Ten common, relevant, clinical questions are addressed, based on published recommendations, including the indications of isotretinoin, the proposed daily dose, the cumulative isotretinoin dose and the laboratory monitoring needed. Recommendations on special considerations are also addressed, including the timing of procedures and the question of an association of depression or inflammatory bowel disease with isotretinoin. A major limitation is the use of different classification systems for acne across guidelines. The recommended daily dose ranges from 0.3 to 0.5 mg/kg in the European guidelines to up to 1 mg/kg in the US guidelines. A specific duration of treatment of at least 6 months is only recommended in the European guidelines. All guidelines report the need of strict pregnancy prevention measures. The European, French and US guidelines recommend to monitor for symptoms of depression. Important clinical questions that are inconsistently addressed in guidelines include the age indication, the recommendation for a cumulative dose, the timing of procedures, the association of isotretinoin with IBD, the recommendation for preventing acne flares and for appropriate laboratory monitoring. These topics should be clearly included in the recommendations of guidelines as they are often raised in everyday clinical practice.

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Section: Clinical Question 4: Is a Cumulative Dose Necessary?mentioning

confidence: 99%

Comparison of guidelines and consensus articles on the management of patients with acne with oral isotretinoin

Dessinioti

Zouboulis

Bettoli

et al. 2020

Acad Dermatol Venereol

View full text Add to dashboard Cite

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Minor Compounds of Palm Oil: Properties and Potential Applications

Gonzalez‒Diaz¹,

Núñez²

2022

Elaeis Guineensis

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The oil contained in ripe fruits produced by cultivars of African oil palm Elaeis guineensis Jacq., as well as that obtained from fresh fruit bunches of certain inter-specific hybrid cultivars derived from crossbreeding between Elaeis oleifera (Kunth) Cortés and E. guineensis Jacq., have shown to be lipid substrates rich in valuable phytochemicals with exceptional biological properties and functional applications for multiple human health tasks. Eight isoforms of vitamin E (four tocopherols and four tocotrienols), α- and β-carotene, squalene, and various phenolic structures, make up the largest group of minor compounds in palm oil and are essential nutrients with physiological functions that include, but are not limited to their antioxidant properties. Vitamin E regulates the redox (oxidation-reduction) balance in the body, and compounds such as squalene and carotenoids are ubiquitously distributed throughout the body, including cell membranes and lipoproteins. Several studies suggest that regular intake of foods rich in this group of phytonutrients minimizes the reactivity of oxidative chemical species at the cellular level and serves as an effective adjunct in the treatment of oxidative stress.

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Retinoids

Cited by 2 publications

References 73 publications

Comparison of guidelines and consensus articles on the management of patients with acne with oral isotretinoin

Comparison of guidelines and consensus articles on the management of patients with acne with oral isotretinoin

Minor Compounds of Palm Oil: Properties and Potential Applications

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