Retinoid and TGF-β Families: Crosstalk in Development, Neoplasia, Immunity, and Tissue Repair

Xu, Qihe; Kopp, Jeffrey B.

doi:10.1016/j.semnephrol.2012.04.008

Cited by 29 publications

(28 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the meninges strongly express retinaldehyde dehydrogenase 2 (RALDH2), which is responsible for retinoic acid (RA) synthesis 12,13 . RA is a small lipophilic molecule, which acts through nuclear RA receptors (RARs), and has various effects on development, physiology and disease 14–16 . Several previous studies suggest that crosstalk between TGF-β isoforms and retinoids can have synergistic or antagonistic effects on development, neoplasia and the immune system 16,17 .…”

mentioning

confidence: 99%

“…RA is a small lipophilic molecule, which acts through nuclear RA receptors (RARs), and has various effects on development, physiology and disease 14–16 . Several previous studies suggest that crosstalk between TGF-β isoforms and retinoids can have synergistic or antagonistic effects on development, neoplasia and the immune system 16,17 . Although TGF-β1 and RA expression is spatially correlated in the meninges, suggestive of crosstalk, their function in meningeal homeostasis during adulthood is unclear.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury

Wee

Seo

et al. 2014

Nat Commun

View full text Add to dashboard Cite

The meninges forms a critical epithelial barrier, which protects the central nervous system (CNS), and therefore its prompt reconstruction after CNS injury is essential for reducing neuronal damage. Meningeal cells migrate into the lesion site after undergoing an epithelial-mesenchymal transition (EMT) and repair the impaired meninges. However, the molecular mechanisms of meningeal EMT remain largely undefined. Here we show that TGF-β1 and retinoic acid (RA) released from the meninges, together with oxygen tension, could constitute the mechanism for rapid meningeal reconstruction. AKAP12 is an effector of this mechanism, and its expression in meningeal cells is regulated by integrated upstream signals composed of TGF-β1, RA and oxygen tension. Functionally, AKAP12 modulates meningeal EMT by regulating the TGF-β1-non-Smad-SNAI1 signalling pathway. Collectively, TGF-β1, RA and oxygen tension can modulate the dynamic change in AKAP12 expression, causing prompt meningeal reconstruction after CNS injury by regulating the transition between the epithelial and mesenchymal states of meningeal cells.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury

Wee

Seo

et al. 2014

Nat Commun

View full text Add to dashboard Cite

show abstract

“…Interaction between retinoids and TGF- β pathways is highly complex and is likely to be cell and tissue dependent (44). Retinoids can affect TGF- β signaling either positively or negatively, and TGF- β affects the retinoid pathway by suppressing CYP26, leading to decreased RA concentrations (44).…”

Section: Discussionmentioning

confidence: 99%

“…Retinoids can affect TGF- β signaling either positively or negatively, and TGF- β affects the retinoid pathway by suppressing CYP26, leading to decreased RA concentrations (44). For example, in human mesangial cells, RA suppresses TGF- β –mediated action of fibrosis by stimulation of hepatocyte growth factor (45) and in fibroblasts ATRA decreases p-Smad mediated transcription (46).…”

Section: Discussionmentioning

confidence: 99%

Liarozole inhibits transforming growth factor-β3–mediated extracellular matrix formation in human three-dimensional leiomyoma cultures

Levy

Malik

Britten

et al. 2014

Fertility and Sterility

View full text Add to dashboard Cite

Objective To investigate the impact of liarozole on transforming growth factor-β3 (TGF-β3) expression, TGF-β3 controlled profibrotic cytokines, and extracellular matrix formation in a three-dimensional (3D) leiomyoma model system. Design Molecular and immunohistochemical analysis in a cell line evaluated in a three-dimensional culture. Setting Laboratory study. Patient(s) None. Intervention(s) Treatment of leiomyoma and myometrial cells with liarozole and TGF-β3 in a three-dimensional culture system. Main Outcome Measure(s) Quantitative real-time reverse-transcriptase polymerase chain reaction and Western blotting to assess fold gene and protein expression of TGF-β3 and TGF-β3 regulated fibrotic cytokines: collagen 1A1 (COL1A1), fibronectin, and versican before and after treatment with liarozole, and confirmatory immunohistochemical stains of treated three-dimensional cultures. Result(s) Both TGF-β3 gene and protein expression were elevated in leiomyoma cells compared with myometrium in two-dimensional and 3D cultures. Treatment with liarozole decreased TGF-β3 gene and protein expression. Extracellular matrix components versican, COL1A1, and fibronectin were also decreased by liarozole treatment in 3D cultures. Treatment of 3D cultures with TGF-β3 increased gene expression and protein production of COL1A1, fibronectin, and versican. Conclusion(s) Liarozole decreased TGF-β3 and TGF-β3–mediated extracellular matrix expression in a 3D uterine leiomyoma culture system.

show abstract

“…At least in initial human toxicity studies, when carefully dosed, LY 2157229 may have limited cardiac toxicity (Rodon, J et al, 2014). Because TGF- induces retinoic acid which may mediate some signaling thru retinoic acid receptors, targeting the RA signaling pathways may bypass defects in TGF- R III loss in progressively malignant meningiomas (Xu and Kopp, 2012).…”

Section: Targeting Tgf- and Bmp Signaling Alterations In Meningiomasmentioning

confidence: 99%

Transforming Growth Factor-beta Superfamily in Meningiomas: Targets for Novel Therapy in eningiomas

Johnson

2015

IJN

View full text Add to dashboard Cite

Meningiomas are central nervous system tumors with a high recurrence rate. In the absence of effective chemotherapies, inoperable, recurrent and metastatic tumors remain a therapeutic challenge. Members of the TGF- super-family play an integral role in the development, progression and metastases of many malignancies yet may be underappreciated participants in the biology of meningiomas. This paper reviews the common abnormalities in TGF- or BMP signaling in neoplasias with a focus on meningiomas. Sites of potential targeting for new chemotherapies are also noted.

show abstract

Retinoid and TGF-β Families: Crosstalk in Development, Neoplasia, Immunity, and Tissue Repair

Cited by 29 publications

References 95 publications

Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury

Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury

Liarozole inhibits transforming growth factor-β3–mediated extracellular matrix formation in human three-dimensional leiomyoma cultures

Transforming Growth Factor-beta Superfamily in Meningiomas: Targets for Novel Therapy in eningiomas

Contact Info

Product

Resources

About