Retinoic acids in oral precancer: Utility and challenges

Pandey, Rahul; Mehrotra, Divya

doi:10.1016/j.ajoms.2020.04.001

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Topical Medications: Topical medications, such as retinoids and 5-fluorouracil (5-FU), are commonly used in the management of the potentially malignant disorders. Retinoids promote the differentiation of abnormal cells or cause cell death, helping normalize cell growth and reduce the risk of malignant transformation [75,76]. On the other hand, 5-FU is an antimetabolite medication that interferes with DNA synthesis and inhibits the growth of abnormal cells.…”

Section: Updates Of Therapeutic Strategies In the Management Of The P...mentioning

confidence: 99%

Genetic Revelation of the Potentially Malignant Disorders in the Oral and Maxillofacial Region

Krishna Das,

Shafiul Kadir,

Ullah Shemanto

et al. 2024

Genetics

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The oral and maxillofacial region is the site of numerous cancer forms. The most frequent cancer, which accounts for more than 90% of these tumors, is squamous cell carcinoma. Genetic changes caused by malignant transformation later result in phenotypic changes in cells. Potentially malignant disorders and circumstances can lead to the development of some malignancies, such as oral squamous cell carcinomas (OSCCs). Because OSCC and precursor lesions cannot be detected early, the 5-year survival rate for OSCC is still only about 50%. Early detection of oral cancer, particularly in the premalignant stage, can greatly reduce death and morbidity. The clinical, histological revelations and etiopathogenesis of a few potentially malignant disorders of the oral and maxillofacial region are reviewed in this chapter.

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Section: Updates Of Therapeutic Strategies In the Management Of The P...mentioning

confidence: 99%

Genetic Revelation of the Potentially Malignant Disorders in the Oral and Maxillofacial Region

Krishna Das,

Shafiul Kadir,

Ullah Shemanto

et al. 2024

Genetics

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Nutrigenomics and microbiome shaping the future of personalized medicine: a review article

Kassem,

Abdelmegid,

El-Sayed

et al. 2023

Journal of Genetic Engineering and Biotechnology

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The relationship between nutrition and genes has long been hinted at and sometimes plainly associated with certain diseases. Now, after many years of research and coincidental findings, it is believed that this relationship, termed “Nutrigenomics,” is certainly a factor of major importance in various conditions. In this review article, we discuss nutrigenomics, starting with basics definitions and enzymatic functions and ending with its palpable association with cancer. Now, diet is basically what we eat on a daily basis. Everything that enters through our alimentary tract ends up broken down to minute molecules and amino acids. These molecules interact with our microbiome and genome in discreet ways. For instance, we demonstrate how proper intake of probiotics enhances beneficial bacteria and may alleviate IBS and prevent colorectal cancer on the long term. We also show how a diet rich in folic acid is essential for methylenetetrahydrofolate reductase (MTHFR) function, which lowers risk of colorectal cancer. Also, we discuss how certain diets were associated with development of certain cancers. For example, red and processed meat are highly associated with colorectal and prostate cancer, salty diets with stomach cancer, and obesity with breast cancer. The modification of these diets significantly lowered the risk and improved prognosis of these cancers among many others. We also examined how micronutrients had a role in cancer prevention, as vitamin A and C exert anti-carcinogenic effects through their function as antioxidants. In addition, we show how folic acid prevent DNA mutations by enhancing protein methylation processes. Finally, after a systematic review of myriad articles on the etiology and prevention of cancer, we think that diet should be a crucial feature in cancer prevention and treatment programs. In the future, healthy diets and micronutrients may even be able to successively alter the liability to genetic mutations that result in cancer. It also will play a role in boosting treatment and improving prognosis of diagnosed cancers.

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Retinoic acids in oral precancer: Utility and challenges

Cited by 2 publications

References 54 publications

Genetic Revelation of the Potentially Malignant Disorders in the Oral and Maxillofacial Region

Genetic Revelation of the Potentially Malignant Disorders in the Oral and Maxillofacial Region

Nutrigenomics and microbiome shaping the future of personalized medicine: a review article

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