Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153–C/EBPβ interaction

Elizondo, Guillermo; Medina-Díaz, Irma Martha; Cruz, Raymundo; Gonzalez, Frank J.; Vega, Libia

doi:10.1016/j.bcp.2008.10.011

Cited by 37 publications

(40 citation statements)

References 44 publications

(44 reference statements)

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“…Expression of cyp26a1 and aldh1a2 has been shown to be feedback-controlled by RA during somitogenesis (Begemann et al, 2001;Dobbs-McAuliffe et al, 2004), which has been explained as a direct effect of RA on the respective promoters (DobbsMcAuliffe et al, 2004;Loudig et al, 2005;Elizondo et al, 2009). We show that RA-depleted embryos show similar effects on cyp26a1 and aldh1a2 expression in the hypoblast already during gastrulation, suggesting that RA already exerts control on gene expression during gastrulation.…”

Section: Discussionsupporting

confidence: 56%

Zebrafish limb development is triggered by a retinoic acid signal during gastrulation

Grandel¹,

Brand²

2010

Developmental Dynamics

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Studies in mouse and zebrafish show that vertebrate forelimb development is initiated by retinoic acid (RA). An RA signal leads to transcription of tbx5 in forelimb precursors which is necessary and sufficient for limb development. However, the timing of the RA signaling event has remained controversial as have source tissue and tissue interactions. We have thus determined the contribution of RA to zebrafish pectoral fin development at different developmental stages. Specifically, an early gastrula stage RA signal triggers the process that leads to determination of tbx5‐expressing limb precursors, while a later somitogenesis stage RA signal maintains these precursors. Preceding the lack of tbx5‐expressing limb precursors in RA deficient zebrafish embryos, aldh1a2 and cyp26a1 expression domains are distorted along the gastrula margin suggesting that positional values in the ventrolateral mesodermal anlagen are affected. We propose that limb precursor determination requires RA dependent specification of lateral plate territories during gastrulation. Developmental Dynamics 240:1116–1126, 2011. © 2010 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 56%

Zebrafish limb development is triggered by a retinoic acid signal during gastrulation

Grandel¹,

Brand²

2010

Developmental Dynamics

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“…45 Known RA-mediated transcriptional responses were enhanced in the tissues of RE rats at weaning (day 21), including downregulation of Aldh 1a1 expression in iWAT. 13,49 Downregulation of Aldh 1a1 in the face of upregulation of the RA-degrading enzyme CYP26a1 is suggestive of a homeostatic mechanism to keep constant intracellular RA levels in WAT. The increased cell proliferation potential found in iWAT of young RE-treated rats is in line with repressive effects of RA on the expression of cell cycle breaks (p21 and retinoblastoma protein) previously reported in adipocyte cell models, 50 and with increased thymidine incorporation in cultured adipose precursor cells exposed to RA.…”

Section: Discussionmentioning

confidence: 99%

Vitamin A supplementation in early life affects later response to an obesogenic diet in rats

et al. 2012

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OBJECTIVE:To assess the influence of supplementation with a moderate dose of vitamin A in early life on adipose tissue development and the response to an obesogenic diet later in life. METHODS: During the suckling period, rat pups received a daily oral dose of retinyl palmitate corresponding to three times the vitamin A ingested daily from maternal milk. Control rats received the vehicle (olive oil). Short-term effects of treatment on gene expression and morphology of white adipose tissue (WAT) were analyzed in animals on the day after weaning (day 21). To study long-term effects, control and vitamin A-treated rats were fed, after weaning, a normal fat or a high-fat (HF) diet for 16 weeks. RESULTS: WAT of vitamin A-treated young rats (day 21) was enriched in small adipocytes with a reduced expression of adipogenic markers (peroxisome proliferator-activated receptor g and lipoprotein lipase) and an increased cell proliferation potential as indicated by increased expression of proliferating cell nuclear antigen. Increased retinoic acid (RA)-induced transcriptional responses were present in the tissues of vitamin A-treated young rats (day 21) including WAT. Vitamin A-treated rats developed higher adiposity than control rats on a HF diet as indicated by body composition analysis and increased WAT depot mass, adipocyte diameter, WAT DNA content, leptinemia and adipose leptin gene expression. Excess adiposity gain in vitamin A-treated rats developed in the absence of changes in body weight and was attributable to excess adipocyte hyperplasia. No differences in adiposity were observed between vitamin A-treated rats and control rats on a normal fat diet. Total retinol levels in WAT of vitamin A-treated rats were elevated at weaning (day 21) and normalized by day 135 of age. CONCLUSION: Vitamin A intake in the early stages of postnatal life favors subsequent HF diet-induced adiposity gain through mechanisms that may relate to changes in adipose tissue development, likely mediated by RA.

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“…ALDHs convert retinaldehyde to RA. RA is the signaling effector molecule and binds retinoic acid receptors (RAR) or retinoid X receptors (RXR) (62), which then bind specific DNA sequences in promoters to regulate gene expression (13,63). Several retinoids have previously been investigated for treating cancers to increase effectiveness of standard chemotherapy (64)(65)(66).…”

Section: Figurementioning

confidence: 99%

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

2016

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Resistance to current chemotherapeutic or radiation-based cancer treatment strategies is a serious concern. Cancer stem cells (CSCs) are typically able to evade treatment and establish a recurrent tumor or metastasis, and it is these that lead to the majority of cancer deaths. Therefore, a major current goal is to develop treatment strategies that eliminate the resistant CSCs as well as the bulk tumor cells in order to achieve complete disease clearance. Aldehyde dehydrogenases (ALDHs) are important for maintenance and differentiation of stem cells as well as normal development. There is expanding evidence that ALDH expression increases in response to therapy and promotes chemoresistance and survival mechanisms in CSCs. This perspective will discuss a paper by

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Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153–C/EBPβ interaction

Cited by 37 publications

References 44 publications

Zebrafish limb development is triggered by a retinoic acid signal during gastrulation

Zebrafish limb development is triggered by a retinoic acid signal during gastrulation

Vitamin A supplementation in early life affects later response to an obesogenic diet in rats

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

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