Biochemical Pharmacology volume 77, issue 2, P248-257 2009 DOI: 10.1016/j.bcp.2008.10.011 View full text
Guillermo Elizondo, Irma M. Medina-Díaz, Raymundo Cruz, Frank J. Gonzalez, Libia Vega

Abstract: AbstractMammalian class I aldehyde dehydrogenase (ALDH) plays an important role in the biosynthesis of the hormone retinoic acid (RA), which modulates gene expression and cell differentiation. RA has been shown to mediate control of human ALDH1 gene expression through modulation of the retinoic acid receptor α (RARα) and the CCAAT/enhancer binding protein β (C/EBPβ). The positive activation of these transcription factors on the ALDH1 promoter is inhibited by RA through a decrease of C/EBPβ binding to the ALDH…

expand abstract