Retinoic acid-mediated growth inhibition of small cell lung cancer cells is associated with reduced myc and increased p27Kip1 Expression

Cell cycle genes as targets of retinoid induced ovarian tumor cell growth suppression

“…Since cdk 2 is the partner for cyclin E, it is likely that the RA-dependent increase in p27 results in increased binding of the cyclin E/cdk 2 complex by p27, leading to decreased cyclin E/cdk 2 kinase activity and, as a consequence, hypophosphorylation of RB in mid to late G-1. This idea is supported by studies which suggest that p27 up-regulation could be a primary response in RA treated cells (Borriello et al, 2000;Matsuo and Thiele, 1998;Weber et al, 1999;Zancai et al, 1998;Zhu et al, 1997). Interestingly this upregulation is at the protein level but not at the mRNA level (Borriello et al, 2000;Matsuo and Thiele, 1998;Zancai et al, 1998).…”

“…In contrast, another report utilizing the human small cell lung carcinoma cell line H209 which is RAR-b negative and resistant to RA induced growth inhibition, showed no change of p27 expression upon RA treatment. However, when this cell line was transfected with RAR-b, the cells showed growth inhibition and p27 up-regulation (Weber et al, 1999). This suggests that RA induced growth arrest of human small cell lung carcinoma cells involves RAR-b mediated induction of p27.…”

ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a

“…, accompanied by reduced CDK 4/6 activity and Rb phosphorylation (Zauberman et al , 1997;Robson et al, 1999;Weber et al, 1999;Onishi et al, 2000;Verlinden et al, 2000;Kavanagh et al, 2001). Of the CDKIs, p15…”

Inhibition of cell proliferation by 2-fluorobenzaldehyde retinoic acid conjugate through suppression of STAT3 activation in human glioma cells

“…Retinoic acid exhibits inhibitory effect on the colon cancer (Zheng et al, 1999), prostate cancer (Liang et al, 1999) and lung cancer (Weber et al, 1999). Retinoic acid has also been shown to be of vital importance in the treatment of recurrent malignant cerebral gliomas (Yung et al, 1994).…”