Abstract:Several viruses have been reported to induce EMT in culture models, with their functional relevance remaining under-studied. Here, by linking the activation of EMT-TFs Snail and Slug by RLRs and the widespread observation of EMT by RNA viruses, we propose that EMT is a general cellular response in epithelial cells to RNA viral infections. Using viral genomic RNA and dsRNA analog transfection models, we identify that viral RNAs are strong inducers of EMT-TFs Snail and Slug, which required the phosphorylation of… Show more
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