Retinoic Acid Induces Cyclic Changes in Epidermal Thickness and Dermal Collagen and Glycosaminoglycan Biosynthesis Rates

Schiltz, John R.; Lanigan, Julia; Nabial, Wanda; Petty, Barbara D.; Birnbaum, Jay E.

doi:10.1111/1523-1747.ep12456390

Cited by 27 publications

(12 citation statements)

References 17 publications

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“…Three months of treatment with 0.05% tretinoin revealed significantly increased laser Doppler velocime try responses after trafuril stimulation supporting the increased vessel proliferation in the upper dermis [51]. The same findings were reported in vivo in animals: guinea pig cars, treated for 40 days with topical retinoic acid showed an 81% increase in blood flow [52].…”

Section: Cutaneous Blood Flowsupporting

confidence: 78%

Skin Bioengineering in the Noninvasive Assessment of Cutaneous Aging

et al. 1991

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Cutaneous changes induced by aging can be quantified and monitored noninvasively by means of bioengineering tools. Skin elasticity, hydration, skin blood flow and skin surface pattern show age-related changes reflecting the damage of cutaneous structures involved. Impairment and degeneration of elastic and collagen networks are responsible for the progressive decrease in skin elasticity recorded during aging. Reduction in blood flow and water supply with probably defective stratum corneum binding result in reduced stratum corneum water content and transepidermal water loss. Morphological changes such as increased skin roughness pigmentation and alteration of skin surface pattern appearing from the age of 30 years onwards may be investigated at a subclinical level allowing the detection of early signs of aging.

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Section: Cutaneous Blood Flowsupporting

confidence: 78%

Skin Bioengineering in the Noninvasive Assessment of Cutaneous Aging

et al. 1991

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“…Increased vascularity of the dermis may be an important aspect of tretinoin treatment of photoaging and intrinsic aging of skin218; indeed, many of the clinical and histologie changes in the skin due to treti¬ noin treatment may require the increased blood flow that accompanies the increased vascularity. 19 As previously observed," tretinoin treatment increased intracellular (ie, fibroblast) staining for pN collagen I, indicating procollagen I formation and pre¬ sumably subsequent formation of collagen I. pN Colla¬ gen I was increased in fibroblasts of skin treated with both doses of tretinoin, although it reached statistical significance compared with vehicle treatment only in the 0.025% tretinoin group, presumably due to few samples in the 0.1% tretinoin group. Unlike our previ¬ ous study of photoaged forearms, we did not observe significant restoration of papillary dermal extracellular pN collagen I staining in tretinoin-treated facial skin, perhaps due to the relatively small number of biopsy specimens that were assessed.…”

Section: Treatment Of the Forearmssupporting

confidence: 65%

Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation

et al. 1995

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“…Retinoic Acid Treatment 0.05% retinoic acid in ethanol was painted on both sides of the right pinna for 5 successive days [8]. At various times after the last painting, mice were sacrificed and donated for histological analy sis.…”

Section: Cell Transfermentioning

confidence: 99%

Induction of Eczematous Skin Reaction in Experimentally Induced Hyperplastic Skin of Balb/C Mice by Monoclonal Anti-DNP IgE Antibody: Possible Implications for Skin Lesion Formation in Atopic Dermatitis

Katayama

Tanei²,

Yokozeki³

et al. 1990

Int Arch Allergy Immunol

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Biphasic skin reaction with peak response at 1 and 24 h with prominent mast cell degranulation was induced by intravenous application of a monoclonal anti-DNP IgE antibody and subsequent skin test. This reaction was hapten-specifíc and mast-cell-dependent because no reaction was observed when oxasolone was used as an elicitation antigen or skin test was elicited in genetically mast-cell-deficient mice (W/Wvv). A partial spongiotic reaction and mononuclear cell infiltration into the epidermis were observed in mice with hyperplastic epidermis induced by topical retinoic acid. Cotransfer of DNFB-sensitized lymph node cells with anti-DNP IgE antibodies failed to enhance the skin test reaction in unsensitized mice. These results suggest that, to some degree, IgE antibody may play some role in the development of eczematous skin lesions in the rodent system without the involvement of cellular hypersensitivity.

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Retinoic Acid Induces Cyclic Changes in Epidermal Thickness and Dermal Collagen and Glycosaminoglycan Biosynthesis Rates

Cited by 27 publications

References 17 publications

Skin Bioengineering in the Noninvasive Assessment of Cutaneous Aging

Skin Bioengineering in the Noninvasive Assessment of Cutaneous Aging

Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation

Induction of Eczematous Skin Reaction in Experimentally Induced Hyperplastic Skin of Balb/C Mice by Monoclonal Anti-DNP IgE Antibody: Possible Implications for Skin Lesion Formation in Atopic Dermatitis

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