Retinoic acid and meiosis induction in adult versus embryonic gonads of medaka

Adolfi, Mateus Contar; Herpin, Amaury; Regensburger, Martina; Sacquegno, Jacopo; Waxman, Joshua S.; Schartl, Manfred

doi:10.1038/srep34281

Cited by 30 publications

(31 citation statements)

References 59 publications

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“…Cyp26b1 acts as a meiosis-inhibiting factor in mammals, birds, and amphibians ( Bowles and Koopman 2010 ; Piprek, Pecio, Laskowska-Kaszub, Kloc, et al 2013 ; Yu et al. 2013 ), while in teleosts this role is exerted by cyp26a1 ( Adolfi et al. 2016 ).…”

Section: Resultsmentioning

confidence: 99%

A Comparative View on Sex Differentiation and Gametogenesis Genes in Lungfish and Coelacanths

Biscotti

Adolfi

Barucca

et al. 2018

Genome Biology and Evolution

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Gonadal sex differentiation and reproduction are the keys to the perpetuation of favorable gene combinations and positively selected traits. In vertebrates, several gonad development features that differentiate tetrapods and fishes are likely to be, at least in part, related to the water-to-land transition. The collection of information from basal sarcopterygians, coelacanths, and lungfishes, is crucial to improve our understanding of the molecular evolution of pathways involved in reproductive functions, since these organisms are generally regarded as “living fossils” and as the direct ancestors of tetrapods. Here, we report for the first time the characterization of >50 genes related to sex differentiation and gametogenesis in Latimeria menadoensis and Protopterus annectens. Although the expression profiles of most genes is consistent with the intermediate position of basal sarcopterygians between actinopterygian fish and tetrapods, their phylogenetic placement and presence/absence patterns often reveal a closer affinity to the tetrapod orthologs. On the other hand, particular genes, for example, the male gonad factor gsdf (Gonadal Soma-Derived Factor), provide examples of ancestral traits shared with actinopterygians, which disappeared in the tetrapod lineage.

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Section: Resultsmentioning

confidence: 99%

A Comparative View on Sex Differentiation and Gametogenesis Genes in Lungfish and Coelacanths

Biscotti

Adolfi

Barucca

et al. 2018

Genome Biology and Evolution

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“…In mammals, bone morphogenetic protein and retinoic acid (RA) signaling induce female-type differentiation (oogenesis) and meiosis, respectively (17)(18)(19)(20)(21)(22). By contrast, in medaka, it appears that RA signaling does not play a critical role in meiosis initiation during the sex determination period (23). Furthermore, a RA-responsive gene, stimulated by retinoic acid gene 8, has been lost from most teleost genomes (24).…”

Section: Discussionmentioning

confidence: 99%

foxl3 , a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka

Kikuchi

Nishimura

Ishishita

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Germ cells have the ability to differentiate into eggs and sperm and must determine their sexual fate. In vertebrates, the mechanism of commitment to oogenesis following the sexual fate decision in germ cells remains unknown.Forkhead-box protein L3(foxl3) is a switch gene involved in the germline sexual fate decision in the teleost fish medaka (Oryzias latipes). Here, we show thatfoxl3organizes two independent pathways of oogenesis regulated byREC8 meiotic recombination protein a(rec8a), a cohesin component, andF-box protein(FBP) 47(fbxo47), a subunit of E3 ubiquitin ligase. In mutants of either gene, germ cells failed to undergo oogenesis but developed normally into sperm in testes. Disruption ofrec8aresulted in arrest at a meiotic pachytenelike stage specifically in females, revealing a sexual difference in meiotic progression. Analyses offbxo47mutants showed that this gene regulates transcription factors that facilitate folliculogenesis:LIM homeobox 8(lhx8b),factor in the germlineα (figla), andnewborn ovary homeobox(nobox). Interestingly, we found that thefbxo47pathway ensures that germ cells do not deviate from an oogenic pathway until they reach diplotene stage. The mutant phenotypes together with the timing of their expression imply that germline feminization is established during early meiotic prophase I.

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“…The immature status of S. pyrenaicus gonads could be the source of the lower d N / d S ratios in expressed male‐biased genes versus the higher values detected for female‐biased genes, given that transcriptomes from non‐mature gonads are not replete in genes that are required for late gametogenesis. In fact, retinoic acid metabolism from fish outside the breeding season is shifted towards degradation in S. pyrenaicus females, with high ovarian expression of cyp26a1 (Table ), which is commonly found in immature pre‐vitellogenic oocytes at early prophase I‐arrest in other teleost fish (Rodríguez‐Marí et al, ; Adolfi et al, ).…”

Section: Discussionmentioning

confidence: 99%

Non‐canonical expression patterns and evolutionary rates of sex‐biased genes in a seasonal fish

Machado

Matos

Grosso

et al. 2016

Molecular Reproduction Devel

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Sex determination is a highly variable process that utilizes many different mechanisms to initiate the cascade of differentiation processes. The molecular pathways controlling sexual development are less conserved than previously assumed, and appear to require active maintenance in some species; indeed, the developmental decision of gonad phenotype in gonochoristic species is not fixed at an early developmental stage. Much of the knowledge about sex determination mechanisms was derived from research on gonochoristic, non-seasonal breeders. In this study, the transcriptome of resting adult gonads of a seasonal breeder, the endangered Iberian cyprinid fish Squalius pyrenaicus, was analyzed to assess the expression patterns and evolutionary rates of sex-biased genes that could be involved in maintenance of gonad identity as well as in sex determination. Remarkably, some crucial female genes-such as aromatase cyp19a1a, estrogen receptor esr1a, and foxl2-were expressed more abundantly in S. pyrenaicus testis than in ovaries. Moreover, contrary to the higher evolutionary rate changes observed in male-biased genes, higher d /d ratios were observed for female-biased genes than for male-biased genes in S. pyrenaicus. These results help unravel the impact of seasonality in sex determination mechanisms and the evolution of genes, and highlight the need to study fish at different gonadal maturation states to understand the function of sex-biased genes. Mol. Reprod. Dev. 83: 1102-1115, 2016. © 2016 Wiley Periodicals, Inc.

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Retinoic acid and meiosis induction in adult versus embryonic gonads of medaka

Cited by 30 publications

References 59 publications

A Comparative View on Sex Differentiation and Gametogenesis Genes in Lungfish and Coelacanths

A Comparative View on Sex Differentiation and Gametogenesis Genes in Lungfish and Coelacanths

foxl3 , a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka

Non‐canonical expression patterns and evolutionary rates of sex‐biased genes in a seasonal fish

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