Retinohypothalamic projections in the common marmoset (Callithrix jacchus): A study using cholera toxin subunit B

Costa, Mirian Stela Maris de Oliveira; Santee, Umbelina R.; Cavalcante, Jeferson de Souza; Moraes, Paulo Ranieri de Araújo; Santos, Natally Pereira dos; Britto, Luiz Roberto Giorgetti de

doi:10.1002/(sici)1096-9861(19991220)415:3<393::aid-cne5>3.0.co;2-r

Cited by 40 publications

(34 citation statements)

References 64 publications

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“…It is possible that these differences merely reflect individual variations and methodological drawbacks such as the higher sensitivity of the CTb tracing technique used here (Major et al, 2003). Costa et al (1999) suggested that contralateral or ipsilateral asymmetry might be due to selective uptake of the tracer by specific groups of ganglion cells in the retina of different species.…”

Section: Suprachiasmatic Nucleusmentioning

confidence: 62%

“…This technique has been successfully applied in primates to trace retinal projections to several targets (Angelucci et al, 1996;Cavalcante et al, 2005;Costa et al, 1999;Frazão et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

“…The pattern of distribution of retinal projections shows that retinal cells project to both the contra-and ipsi-lateral SCN in C. apella monkeys, with a contralateral predominance as described for rodents and other primates (Costa et al, 1999;Hendrickson et al, 1972;Johnson et al, 1988;Levine et al, 1991;Major et al, 2003;Moore and Lenn, 1972;Moore, 1973), although a wide distribution also exists on the ipsilateral side. In the diurnal ground squirrel (Spermophilus lateralis or Citellus tridecemlineatus), retinal projections within the hypothalamus appear to be restricted to the contralateral SCN, with no labeled fibers being observed in the ipsilateral SCN (Agarwala et al, 1989).…”

Section: Suprachiasmatic Nucleusmentioning

confidence: 99%

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Immunocytochemical characterization of the pregeniculate nucleus and distribution of retinal and neuropeptide Y terminals in the suprachiasmatic nucleus of the Cebus monkey

Pinato

Frazão

Cruz-Rizzolo

et al. 2009

Journal of Chemical Neuroanatomy

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Section: Suprachiasmatic Nucleusmentioning

confidence: 62%

Section: Methodsmentioning

confidence: 99%

Section: Suprachiasmatic Nucleusmentioning

confidence: 99%

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Immunocytochemical characterization of the pregeniculate nucleus and distribution of retinal and neuropeptide Y terminals in the suprachiasmatic nucleus of the Cebus monkey

Pinato

Frazão

Cruz-Rizzolo

et al. 2009

Journal of Chemical Neuroanatomy

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“…A existência da principal via sincronizadora deste sistema, o trato retinohipotalâmico (TRH), foi confirmada em estudos realizados em várias espécies de mamíferos, incluindo primatas do Velho e do Novo mundo (Hendrickson, Wagoner e Cowan, 1972;Moore, Lenn, 1972;Moore, 1973;1993;Costa et al, 1999;Cavalcante, 2000).…”

Section: Projeções Retinianasunclassified

“…As descrições originais do TRH, baseadas em técnicas de auto-radiografia, descrevem projeções da retina, no hipotálamo, exclusivamente para o NSQ (Hendrickson, Wagoner e Cowan, 1972;Moore, 1973), entretanto, a utilização de traçadores neurais mais sensíveis, tais como toxina colérica, tornou evidente a existência de projeções para outras regiões do hipotálamo como, por exemplo, para área pré-óptica medial, área pré-óptica lateral, núcleo pré-óptico mediano, núcleo paraventricular, área hipotalâmica anterior, área hipotalâmica lateral, núcleo supra-óptico, área retroquiasmática e zona subparaventricular (Levine et al, 1991;Youngstrom, Weiss e Nunez, 1991;Moore, 1993;Costa et al, 1999;Cavalcante, 2000).…”

Section: Projeções Retinianasunclassified

Análise citoarquitetônica e imunoistoquímica de estruturas do sistema visual de macacos-prego (Cebus apella)

Frazão¹

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tracer cholera toxin subunit B CTb (1:100, diluted in distilled water containing 10% dimethylsulfoxide). The animals were perfused 15 days after the injection. The retina from the contralateral eyeball was removed to immunohistochemical analysis. The brain was removed from the skull, sectioned into frontal sections and processed with immunohistochemical techniques against CTb to identify the projections from the retina to the CNS. Several cell markers were used to characterize cytochemically different cell types in the retina. The most striking result was the identification of two unique types of bipolar cells. In addition, the tufted capuchin retina, unlike other mammals species analyzed in the literature, shows co-localization with gabaergic receptors. As expected, projections from the retina were observed in all structures of the primary visual system and optic accessory. As a complementary data, retinal projections were also observed in areas not related to the image processing, such as the circadian control system. Overall our results showed several interspecies differences and suggests that comparison of the visual system between species must be undertaken with great caution.Keywords: Visual system, tufted capuchin, cholera toxin subunit B, circadian system, retinal projections. INTRODUÇÃO RetinaA retina é uma fina lâmina de tecido nervoso (cerca de 200 µm de espessura) que se deslocou do encéfalo para o fundo do olho durante o desenvolvimento. Sua função é converter a informação óptica em imagem neural que será transmitida via nervo óptico à diversos núcleos para análise e composição da imagem. Assim, sua função é associar aspectos temporais, espaciais e cromáticos da informação visual, sendo os sinais resultantes transmitidos para áreas visuais centrais (Kalloniatis, Fletcher, 2004;Sterling, Demb, 2004).A retina apresenta três camadas celulares bem organizadas, cada qual representada por tipos celulares específicos, que se distinguem por suas características morfológicas, conectivas, neuroquímicas, e funcionais (Rodieck, Brening, 1983;Sterling, 1983).Em adição aos fotorreceptores, sensíveis à luz, há ainda cinco classes celulares de neurônios e um tipo principal de célula da glia, as células de Müller. A camada nuclear externa (ONL) contém os corpos celulares de fotorreceptores (cones e bastonetes) e processos das células de Müller. As células de Müller se estendem por todas as camadas da retina e são responsáveis pela formação da membrana limitante externa, em conjunto com os segmentos externos dos fotorreceptores, e da membrana limitante interna, que forma uma barreira entre a retina e o humor vítreo (Dowling, 2002). FotorreceptoresOs fotorreceptores, cones e bastonetes, são células alongadas que apresentam os segmentos externos direcionados para a região posterior do globo ocular, onde estão envolvidos por epitélio pigmentar. O segmento externo de cada fotorreceptor contém cerca de 900 discos membranosos, posicionados perpendicularmente em relação ao longo eixo da célula. A superfície do disco é preen...

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Pattern of retinal projections in the California ground squirrel (Spermophilus beecheyi): Anterograde tracing study using cholera toxin

Major

Rodman

Libedinsky

et al. 2003

J of Comparative Neurology

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The retinofugal pathways in the California ground squirrel, Spermophilus beecheyi, were mapped after intravitreal injections of cholera toxin B-subunit. The results of the current study are consistent with work in other mammals and provide new details relevant to the organization and evolution of the visual system. All retinorecipient nuclei received bilateral input, with a contralateral predominance. The suprachiasmatic nucleus is heavily innervated, and sparse terminals were noted in other hypothalamic areas. In addition to the interstitial, medial, lateral, and dorsal terminal nuclei, a few fibers of the accessory optic tract may enter the ventral lateral geniculate and the nucleus of the optic tract, though this innervation may not derive from the same ganglion cells innervating the accessory optic nuclei. Retinal terminals are found in the intergeniculate leaflet and the "dorsal cap" of the ventral lateral geniculate. Retinal fibers pass rostrally from the dorsal cap toward the anterodorsal thalamus, confirming a projection described in the tree shrew and monkeys. Retinal termination patterns in the dorsal lateral geniculate reveal a hexilaminate organization of alternating ipsilateral and contralateral input. Variations in terminal morphology suggest that sublayers receive input from distinct ganglion cell types and that laminar comparisons can be made with primates. Finally, terminal patterns in the superior colliculus reveal a dense, highly ordered columnar organization supporting functional properties of tectal receptive fields. All the visual structures in the ground squirrel are large and well differentiated, making the sciurid visual system an accessible rodent model for comparing visual processing with that in other diurnal vertebrates.

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Retinohypothalamic projections in the common marmoset (Callithrix jacchus): A study using cholera toxin subunit B

Cited by 40 publications

References 64 publications

Immunocytochemical characterization of the pregeniculate nucleus and distribution of retinal and neuropeptide Y terminals in the suprachiasmatic nucleus of the Cebus monkey

Immunocytochemical characterization of the pregeniculate nucleus and distribution of retinal and neuropeptide Y terminals in the suprachiasmatic nucleus of the Cebus monkey

Análise citoarquitetônica e imunoistoquímica de estruturas do sistema visual de macacos-prego (Cebus apella)

Pattern of retinal projections in the California ground squirrel (Spermophilus beecheyi): Anterograde tracing study using cholera toxin

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