Retinochoroidal Mass: A Presenting Feature of Metastatic Oat Cell Carcinoma of Lung

Gupta, Mohit; Puri, Pankaj; Jacques, R; Rennie, I G

doi:10.1177/112067210201200618

Cited by 7 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The other modalities included subretinal fluid aspiration or choroidal mass fine needle aspiration cytology or biopsy (n = 4), 2,9,77 lobectomy or surgical lung biopsy (n = 3), 8,33,62 image-guided fine needle aspiration cytology of the lung lesion (n = 5 including 3 index cases), 5,71 and biopsy from extrapulmonary and extraocular metastatic sites (n = 3). 24,26,79 The most commonly identified metastatic site other than the eye was liver (n = 17), with similar frequency in brain (n = 16), adrenals and bones (14 each). Tumor (T) stage was available for approximately half of the patients (n = 28) with most patients having either T4 (n = 13) or T1 (n = 8) lesions.…”

Section: Results Of the Literature Reviewmentioning

confidence: 97%

Choroidal Metastasis as a Presenting Manifestation of Lung Cancer

Singh

Kulkarni²,

Aggarwal³

et al. 2012

Medicine

View full text Add to dashboard Cite

Symptomatic choroidal metastasis is a rare presenting manifestation of lung cancer. We describe here 3 patients with non-squamous non-small cell lung cancer who presented with choroidal metastasis and who were diagnosed and treated by the authors. We performed a systematic literature review of the previously reported patients with choroidal metastasis from lung cancer in the English-language literature. We excluded case series lacking individual patient data and identified 75 patients. In 23 of these patients, choroidal metastasis was not the presenting manifestation of lung cancer. Therefore, we included 55 patients (3 index and 52 previously reported) in the analysis. We present the demographic profile, histology, disease stage, ocular and lung lesions, diagnostic and treatment (systemic and ocular) modalities, and treatment outcomes. The majority of patients were male (67.3%) and were current or ex-smokers (78.3%); the mean age was 55.1 (standard deviation 11.2) years. Adenocarcinoma (n = 23) was the most common histologic type followed by squamous (n = 11) and small cell (n = 8). Left eye (n = 32) involvement was more common than right eye (n = 19) or bilateral (n = 4). Among patients for whom the location of primary lesion was specified, the left upper lobe (n = 13) was the most common site. The most common diagnostic modalities were bronchoscopic lung biopsy (n = 15) and enucleation (n = 13), while the liver (30.9%) was the most common extraocular metastatic site identified. Systemic chemotherapy was given in 56.4% of cases, and disease progression was the most common outcome among evaluable patients. Ocular treatment modalities included radiation (n = 23), enucleation (n = 14), and systemic steroids (n = 8). Regression of choroidal metastases with treatment was observed in 66.7% of patients who did not undergo enucleation as the primary treatment modality. Of the 3 index patients, 2 each received pemetrexed-cisplatin (as first-line therapy), gefitinib or erlotinib (as second- or third-line therapy), and intravitreal bevacizumab; and 1 patient received systemic bevacizumab. Two patients had partial response radiologically with systemic treatment, and all 3 patients had regression of choroidal metastases with ocular treatment. Recommendations regarding systemic and local (ocular) management of patients with choroidal metastasis as the presenting manifestation of lung cancer are provided.

show abstract

Section: Results Of the Literature Reviewmentioning

confidence: 97%

Choroidal Metastasis as a Presenting Manifestation of Lung Cancer

Singh

Kulkarni²,

Aggarwal³

et al. 2012

Medicine

View full text Add to dashboard Cite

show abstract

“…In our literature review of metastatic retinal cancer (Table 1), vitreous involvement in addition to retinal metastasis was found in 17 (41.5%) cases. Optic disc and choroidal involvement together with retinal metastasis were reported in 5 (12.2%) cases [8,10,[12][13][14][15]. Retinal involvement usually starts from the retinal nerve fiber and ganglion cell layers.…”

Section: Discussionmentioning

confidence: 99%

Presumed Retinal Metastasis from Lung Adenocarcinoma: A Case Report and Literature Review

Özcan

Gündüz

Mirzayev

et al. 2021

Case Reports in Ophthalmological Medicine

View full text Add to dashboard Cite

A 63-year-old Caucasian man with metastatic lung adenocarcinoma undergoing chemotherapy and external radiotherapy was referred for routine eye examination. Although he was asymptomatic, ocular examination revealed a relatively well-circumscribed whitish retinal lesion measuring 0.5 × 0.5 × 0.5 mm located along the inferotemporal vascular arcade in the right eye. Optical coherence tomography (OCT) showed a hyperreflective dome-shaped lesion occupying the inner retinal layers with few hyperreflective dots overlying the retina in the posterior vitreous consistent with tumor cells. Fluorescein angiography revealed early hyperfluorescence and late staining without leakage at the lesion site. A diagnosis of presumed retinal metastasis from lung adenocarcinoma was made. At 2 months follow-up after completion of chemotherapy, the retinal lesion was found to have regressed completely leaving minor irregularities in the inner retinal layers on OCT. To date, there have been only 41 cases of carcinoma metastasis to the retina reported in the literature including the current case. Despite its rarity, retinal metastasis should be considered in the differential diagnosis of a white-yellow retinal mass with/without overlying vitreous cells especially in patients with a history of systemic cancer.

show abstract

“…1,2 During the past decades, there have been only a few case reports of retinal metastasis caused by systemic carcinoma. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] In 1990, Leys and colleagues 7 identified a single case of breast carcinoma and another case of lung carcinoma with yellow retinal metastases; the patients died after 1 and 18 months, respectively. Others have reported single cases of retinal metastasis from gastric, colon, and lung carcinoma as well as cutaneous A healthy 59-year-old man developed floaters.…”

Section: Discussionmentioning

confidence: 99%

“…melanoma and unknown sites. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]21 In most cases, the metastases appeared yellow-white, with occasional vitreous seeds or subretinal fluid, and often was misdiagnosed as infectious or inflammatory retinitis. Most patients have been treated with external beam radiotherapy or enucleation.…”

Section: Discussionmentioning

confidence: 99%

Retinal Metastasis From Systemic Cancer in 8 Cases

et al. 2014

View full text Add to dashboard Cite

IMPORTANCE Metastatic tumors of the retina are rare, simulate retinitis, and are associated with poor patient survival.OBJECTIVE To describe the clinical features and outcomes of patients with retinal metastasis from systemic cancer. DESIGN, SETTING, AND PARTICIPANTSRetrospective case series of 8 patients with retinal metastasis from cutaneous melanoma (n = 4), breast cancer (n = 2), esophageal cancer (n = 1), and lung cancer (n = 1). At presentation, the mean patient age was 62 years and all were white.INTERVENTION Treatment included plaque radiotherapy (n = 1) for localized disease or enucleation (n = 3) for extensive tumor hemorrhage (n = 1), total retinal detachment (n = 1), or pain (n = 1). For 4 preterminal patients, observation was preferred. MAIN OUTCOMES AND MEASURES Clinical features and systemic outcomes. RESULTSThe mean interval from primary cancer diagnosis to retinal metastasis was 63 months. Initial misdiagnosis as retinitis (n = 5), hemangioma (n = 1), choroidal neovascular membrane (n = 1), or nerve fiber layer infarction (n = 1) for a mean interval of 5 months was recorded. Visual acuity in the affected eye was 20/40 to 20/60 (n = 5) or 20/400 to light perception (n = 3). The tumors were unilateral (n = 7), involved the macula (n = 3), and had a mean distance to the foveola of 6 mm. In one case, dense vitreous blood precluded fundus visualization. The mean tumor basal dimension was 7.4 mm, and the mean thickness was 2.3 mm. The tumors appeared white (n = 2), yellow (n = 4), or brown (n = 1); were located in the inner retina (n = 6) or full-thickness retina (n = 1); and had vitreous seeds (n = 3), vitreous hemorrhage (n = 2), retinal hemorrhage (n = 4), subretinal fluid (n = 4), and/or intraretinal exudation (n = 1). Fluorescein angiography disclosed early retinal hypofluorescence and late hyperfluorescence with staining. Fine-needle aspiration biopsy confirmed the diagnoses (n = 4). Metastasis-related death occurred in 5 patients within 1 month in each case. Of the remaining 3 patients, 2 were alive at 4 and 17 months and 1 was too sick to return. CONCLUSIONS AND RELEVANCERetinal metastases resemble retinitis, often with delay in diagnosis and poor life prognosis.

show abstract

Retinochoroidal Mass: A Presenting Feature of Metastatic Oat Cell Carcinoma of Lung

Cited by 7 publications

References 7 publications

Choroidal Metastasis as a Presenting Manifestation of Lung Cancer

Choroidal Metastasis as a Presenting Manifestation of Lung Cancer

Presumed Retinal Metastasis from Lung Adenocarcinoma: A Case Report and Literature Review

Retinal Metastasis From Systemic Cancer in 8 Cases

Contact Info

Product

Resources

About