Retinoblastoma: Treatment Options

Kim, Jonathan W.; Murphree, A. Linn; Singh, Arun D.

doi:10.1007/978-3-030-11123-6_10

Cited by 1 publication

(1 citation statement)

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“…Recurrence of the disease has been found to occur years after treatment and is very common these days. Patients with hereditary retinoblastoma also require long-term followup because such patients have an increased lifetime risk of developing secondary malignancies [52].…”

Section: External Beam Radiation (Ebr)mentioning

confidence: 99%

Retinoblastoma: present scenario and future challenges

Byroju,

Nadukkandy,

Cordani

et al. 2023

Cell Commun Signal

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With an average incidence of 1 in every 18,000 live births, retinoblastoma is a rare type of intraocular tumour found to affect patients during their early childhood. It is curable if diagnosed at earlier stages but can become life-threateningly malignant if not treated timely. With no racial or gender predisposition, or even environmental factors known to have been involved in the incidence of the disease, retinoblastoma is often considered a clinical success story in pediatric oncology. The survival rate in highly developed countries is higher than 95% and they have achieved this because of the advancement in the development of diagnostics and treatment techniques. This includes developing the already existing techniques like chemotherapy and embarking on new strategies like enucleation, thermotherapy, cryotherapy, etc. Early diagnosis, studies on the etiopathogenesis and genetics of the disease are the need of the hour for improving the survival rates. According to the Knudson hypothesis, also known as the two hit hypothesis, two hits on the retinoblastoma susceptibility (RB) gene is often considered as the initiating event in the development of the disease. Studies on the molecular basis of the disease have also led to deciphering the downstream events and thus in the discovery of biomarkers and related targeted therapies. Furthermore, improvements in molecular biology techniques enhanced the development of efficient methods for early diagnosis, genetic counseling, and prevention of the disease. In this review, we discuss the genetic and molecular features of retinoblastoma with a special emphasis on the mutation leading to the dysregulation of key signaling pathways involved in cell proliferation, DNA repair, and cellular plasticity. Also, we describe the classification, clinical and epidemiological relevance of the disease, with an emphasis on both the traditional and innovative treatments to tackle retinoblastoma.

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Section: External Beam Radiation (Ebr)mentioning

confidence: 99%