Retinoblastoma en pediatría, experiencia en un hospital pediátrico

Abstract

Retinoblastoma in children, experience at a pediatric hospitalMethods: Retrospective analysis of clinical charts of 41 children (59 eyes) diagnosed with retinoblastoma and treated by a multidisciplinary team at Hospital Luis Calvo Mackenna in Santiago-Chile, between 1999 and 2007. The information included gender, laterality, diagnosis age, presenting signs, tumor spread, treatment modality and survival rate. Results: A total of 23 cases (56%) were unilateral and 18 cases (44%) were bilateral. The mean age at diagnosis was 21.6 months (range 2 -84) and 27 children (65.9%) were male. The most common presenting signs were leucokoria (51.2%), strabismus (24.4%) and proptosis (4.9%). Enucleation was performed in 48 eyes (81.3%), being the only required treatment in 17 children (41.5%). The remaining 24 patients received systemic and/or local therapy with chemotherapy, focal therapy and external beam radiation. 5 children died during the follow -up study period, due to extraocular extension to the orbit, central nervous system and bone marrow. Conclusion: In spite of high enucleation rate as initial therapy for retinoblastoma, the survival rate with this current treatment protocol is similar to those from developed countries.

Manejo multidisciplinario en retinoblastoma: experiencia en 37 ojos

“…Queremos mencionar que la medida de tendencia central utilizada por nosotros fue mediana y no promedio, principalmente por la distribución no homogénea de la muestra. Estos hallazgos hacen comparables nuestros números con los reportados en la literatura de países con mayor grado de desarrollo 2,8,[21][22][23] , y más altos que en reportes anteriores en Latinoamérica (80-94%) 4,8,24 . La supervivencia está asociada al estado de avance de la enfermedad 9 .…”

“…Su incidencia es cercana a 1 en 16.000 nacidos vivos 2 , aunque puede llegar hasta 1 en 34.000 3 . Se estima que en Chile hay 13 nuevos casos por año 4 . La mayoría de los casos se atiende bajo el sistema público, utilizando las Garantías Explícitas en Salud (GES).…”

Molecular diagnosis in patients with retinoblastoma: Report of a series of cases

“…4 In addition, said diagnostic influences therapeutic decisions, as some authors recommend that all germinal retinoblastoma patients should receive systemic chemotherapy to prevent the expression of new tumors and pineoblastoma. 1,3 In our country, survival is comparable to that of developed countries, 5,6 although mortality in Latin America remains close to 20%. 1,3 In our country, survival is comparable to that of developed countries, 5,6 although mortality in Latin America remains close to 20%.…”

Strabismus as a Presenting Sign in Retinoblastoma

“…Within each study, patient presentations were categorized according to a single presenting sign. Trincado et al (18) reported that 2 out of their group of 41 patients sought medical attention due to both leukocoria and strabismus; their cohort did not undergo orthoptic assessments.…”