Retinoblastoma and vision

Warda, Omar; Naeem, Zishan; Roelofs, Kelsey A.; Sagoo, Mandeep S.; Reddy, M. Ashwin

doi:10.1038/s41433-021-01845-y

Cited by 14 publications

(7 citation statements)

References 92 publications

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“…The two most cited papers on the list were on secondary tumors, highlighting the long-term ramifications of using radiation as a treatment for Rb patients and the need for follow-up into later life [ 20 , 21 ]. These studies are becoming more relevant as Rb patient survival increases and secondary tumors develop [ 22 ]. Furthermore, advances in radiology are being made to prevent high doses of radiation in these patients.…”

Section: Discussionmentioning

confidence: 99%

The Most-Cited Articles on Retinoblastoma: A Fifty-Year Perspective

Shemesh

Sandler

Dichter

et al. 2023

Vision

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Purpose: To summarize the characteristics and trends of interest in retinoblastoma (Rb) in the last 50 years. Methods: The Web of Science Database was used to find all studies focused on Rb published from 1970 to 2018. The term “retinoblastoma” was used to search for the 100 most cited records. Results: The mean number of citations was 153.55 ± 88.9. The majority were from the United States (US) (n = 68). Drs. Shields authored 38% of the papers. The number of citations per year was positively correlated with the number of authors, r = 0.26 (p = 0.008). The number of patients was significantly associated with the number of citations per year (p = 0.012). Although papers on radiotherapy were the most common, publications about intra-arterial chemotherapy (IAC) were associated with 88.3% more citations per year (p = 0.031) and papers on intravenous chemotherapy (IVC) were associated with 40.3% more citations per year (p= 0.04). Review and meta-analysis studies had a higher median of citations (10.5) than interventional (6.4) or observational (5.2) studies. Conclusions: This study compiles a comprehensive analysis of the most-cited articles on Rb. Studies with a higher number of citations per year were associated with IAC, which emphasizes the significance of the advances in Rb treatments that allow for the saving of eyes and vision as well as lives. Review studies had more citations than observational or interventional studies. More citations were associated with a larger number of authors or more reported patients per paper. These findings highlight the importance of collaborations to achieve relevant, high-quality research of Rb.

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Section: Discussionmentioning

confidence: 99%

The Most-Cited Articles on Retinoblastoma: A Fifty-Year Perspective

Shemesh

Sandler

Dichter

et al. 2023

Vision

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“…[ 3 ] The therapies of RB mainly include intravenous chemotherapy, intra‐arterial chemotherapy, and Laser. [ 4 ] With the continuous progress of diagnosis and treatment of RB, the RB survival rate has prominently ameliorated. [ 5 ] However, RB's susceptibility to metastasis and resistance to chemotherapy increases the risk of blindness and death in patients.…”

Section: Introductionmentioning

confidence: 99%

MiR‐452‐5p facilitates retinoblastoma cell growth and invasion via the SOCS3/JAK2/STAT3 pathway

Wu,

Huang,

Hong

et al. 2023

J Biochem & Molecular Tox

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Retinoblastoma (RB) is an intraocular tumor in children. Accumulated evidence confirms that microRNAs (miRNAs) exert critical functions in RB. This research aimed to investigate the miR‐452‐5p function in RB. MiR‐452‐5p expressions in RB were tested with quantitative real‐time polymerase chain reaction (PCR). MiR‐452‐5p functions in RB were evaluated via Cell Counting Kit‐8, 5‐Ethynyl‐2′‐deoxyuridine assay, flow cytometry, Western blot, and Transwell. MiR‐452‐5p mechanism in RB was assessed using bioinformatics software Starbase and dual‐luciferase reporter gene assay. Meanwhile, miR‐452‐5p function in RB in vivo was examined by constructing tumor xenografts in nude mice, immunohistochemistry, and Western blot assays. MiR‐452‐5p was overexpressed in RB tissues and cells, and miR‐452‐5p expression was positively correlated with RB clinicopathology including the Largest tumor base (mm) and Differentiation. Functionally, miR‐452‐5p knockdown restrained RB cell proliferation, invasion, epithelial–mesenchymal transition (EMT), and facilitated cell apoptosis. Mechanistically, suppressors of cytokine signaling (SOCS3) knockdown restored the inhibitory effects of miR‐452‐5p knockdown on RB cells. Meanwhile, in vivo studies further corroborated that miR‐452‐5p knockdown reduced RB tumor growth, EMT, and accelerated apoptosis in vivo. Also, miR‐452‐5p knockdown increased SOCS3 protein levels, and decreased phosphorylated Janus kinase 2/Janus kinase 2 (JAK2), phosphorylated signal transducer and activator of transcription 3/signal transducer and activator of transcription 3 (STAT3) in vivo. MiR‐452‐5p accelerated RB cell growth and invasion by SOCS3/JAK2/STAT3.

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“…Such cells eventually stop growing and become mature retinal cells. Sometimes instead of maturing, a few retinoblasts keep on growing uncontrollably, resulting in RB, a form of cancer [2]. Fig.…”

Section: Introductionmentioning

confidence: 99%

Retinoblastoma

Aneesh

Muneeswaran

2022

ijhs

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Eye cancer is extremely rare. It can harm the eye's outer parts, such as the eyelid, which is made up of muscles, skin, and nerves. Intraocular cancer occurs when cancer begins inside the eyeball. Melanoma and lymphoma are perhaps the very familiar intraocular cancers in grown-up person. Retinoblastoma, which begins in the cells of the retina, seems to be the most common type of eye cancer in children. Cancer can also disperse from several other parts of the human body to the eye. Therapies for eye cancer vary depending on the type and stage of the disease. Radiation therapy, Surgery, laser therapy, and freezing or heat therapy are all the possibilities. Medical imaging techniques such as Ultrasound, Magnetic Resonance Imaging and Computed Tomography supports in obtaining the anatomical structure of the eye. By the introduction of the image segmentation algorithms, the infected portion in the eye image is segmented and the information such as the size and location of the tumor is also identified. This can assist the clinicians make more rapid and accurate diagnosis. The various studies using conventional segmentation methodologies on Retinoblastoma were reviewed in this paper.

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Retinoblastoma and vision

Cited by 14 publications

References 92 publications

The Most-Cited Articles on Retinoblastoma: A Fifty-Year Perspective

The Most-Cited Articles on Retinoblastoma: A Fifty-Year Perspective

MiR‐452‐5p facilitates retinoblastoma cell growth and invasion via the SOCS3/JAK2/STAT3 pathway

Retinoblastoma

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