Retinoblastoma and Pseudoglioma

Yanoff, Myron; Sassani, Joseph W.

doi:10.1016/b978-1-4557-2874-9.00018-1

Cited by 2 publications

(2 citation statements)

References 264 publications

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“…These rosettes are composed of a ring of high cuboidal cells surrounding an apical lumen. 10 – 13 Tumor growth rate is limited by the ability to induce the formation of new vessels; hence, large areas of coagulative necrosis and dystrophic calcification frequently appear. 14…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical assay for neuron-specific enolase, synaptophysin, and RB-associated protein as a diagnostic aid in advanced retinoblastomas

et al. 2018

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PurposeWe evaluated the expression of the neural markers, neuron-specific enolase, and synaptophysin, as a tool to confirm the diagnosis of retinoblastoma (RB) in undifferentiated and advanced tumors. Additionally, we determined whether the extent of RB-associated protein (pRb) expression is helpful in assessing the prognosis in RB patients.MethodsConventional whole tissue section and tissue microarray immunohistochemistry for neuron-specific enolase, synaptophysin, and pRb were carried out in a series of 22 RBs.ResultsNeuron-specific enolase and synaptophysin were expressed in 75%–100% of the tumor cells, and the staining intensity was strong. Two RBs expressed pRb in 75%–100% of the tumor cells, also with strong staining intensity. Concordance between the immunohistochemical outcomes for whole tissue staining and tissue microarray staining was 76.2% for neuron-specific enolase, 85.7% for synaptophysin, and 80.0% for pRb.ConclusionNeuron-specific enolase and synaptophysin have the potential to be useful markers for the diagnosis of RBs. Extensive and strong pRb staining is not associated with less aggressive tumor behavior according to the pathologic classification of RBs.

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Section: Introductionmentioning

confidence: 99%

Immunohistochemical assay for neuron-specific enolase, synaptophysin, and RB-associated protein as a diagnostic aid in advanced retinoblastomas

et al. 2018

OPTH

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“…7 Melanomas arising from the pigmented or potentially pigment producing cells of the uvea are the most frequent primary intraocular neoplasms in adults. 8 Retinoblastoma is the most common primary malignancy of young children. 9 The histopathological diagnosis of the diseases plays an important part in patient care.…”

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confidence: 99%