Retinitis pigmentosa and inner retina. Functional study by means of oscillatory potentials of the electroretinogram

Ponte, F.; Anastasi, M.; Lauricella, M.

doi:10.1007/bf00154489

Cited by 10 publications

(11 citation statements)

References 18 publications

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“…First, at later stages of the disease, inner retinal elements are also affected. Even if many of the inner nuclear cells are preserved (Santos et al, 1997 ;Stone et al, 1992), there is electrophysiological evidence for a general as well as a macular loss of inner retinal function (Falsini et al, 1994 ;Hood and Birch, 1996 ;Ponte, Anastasi and Lauricella, 1989). Secondly, the vibratome sectioned transplants do not show normal morphology.…”

Section: Transplant Morphologymentioning

confidence: 94%

Partial and Full-Thickness Neuroretinal Transplants

Ghosh

Juliusson

Arnér

et al. 1999

Experimental Eye Research

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Section: Transplant Morphologymentioning

confidence: 94%

Partial and Full-Thickness Neuroretinal Transplants

Ghosh

Juliusson

Arnér

et al. 1999

Experimental Eye Research

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“…For a comprehensive review of electrophysiology and diabetic retinopathy see Tzekov and Arden [25]. OPs have also been shown to be delayed in some patients with glaucoma [26], hepatic retinopathy [27], congenital stationary night blindness [28], and retinitis pigmentosa [29]; thus they may be sensitive indicators of other types of retinal damage.…”

Section: Introductionmentioning

confidence: 98%

Human oscillatory potentials: intensity-dependence of timing and amplitude

Hancock

Kraft

2008

Doc Ophthalmol

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Oscillatory potentials (OPs) have been described as reduced in amplitude or delayed in diabetic retinopathy, glaucoma, and vascular occlusions. Although OPs are thought to have useful diagnostic applications, some of their basic physiologic properties remain to be fully described. In the present study, we examined the relationship between the timing and amplitude of OPs and stimulus intensity. Five normal volunteers had one eye anesthetized and dilated. Dark-adapted full-field ERGs were recorded to white stimuli of 0.0125-40 cd s/m(2). The timing of the OPs was measured as the sum of the time to the peak (TTP) of four peaks beginning at 15 ms after the stimulus. The amplitude was taken as the sum of the amplitudes of those same peaks. As an alternative value, OP strength was represented by the area under the OP curve or power around 150 Hz (+/-30 Hz) in the frequency domain. The OP timing, as measured by TTP, was found to be inversely related to stimulus intensity. OP-amplitudes grew with intensity, but then declined for stimulus intensities above about 4 cd s/m(2). At bright light intensities, the TTP continued to shorten, yet amplitudes, power, and area all declined. Individual OPs behaved similarly and reflected the overall response pattern of the group as a whole. Brighter stimuli produced larger, faster OPs for stimulus strengths up to the intensity standard used to produce OPs (3.5 cd s/m(2)). We have extended the range of stimuli to some 10-fold higher than the ISCEV standard for producing OPs and found that the timing continued to accelerate but that OP-amplitudes, OP-area, and OP-power all decline at higher stimulus intensities. These alternative measures of OP energy are easily measured and may be useful for further studies.

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“…Recently, a difference between the evolution of the ERG Oscillatory Potentials (OPs), which reflect the activity of the inner retina (Speros & Price 1981), and the 20 Hz ERG response was found: unlike what was expected, a residual 20 Hz response was present in a consistent number of patients whose photopic OPs were no longer recordable (Ponte et al 1989).…”

mentioning

confidence: 94%

Photopic ERG components in retinitis pigmentosa

Anastasi¹,

Lauricella²,

Ponte³

1992

Acta Ophthalmologica

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The persistence of a residual flicker electroretinogram 20 Hz response in many cases of retinitis pigmentosa, when the Oscillatory Potentials (OPs) were no longer recordable, led the authors to an investigation by Fourier analysis. The study was carried out in 33 patients affected by different hereditary forms of retinitis pigmentosa revealing recordable 20 Hz flash ERG responses. We applied the Fourier analysis to this ERG response and compared the weight percentage of the first two components to the OP added amplitude. The analysis showed that the 20 Hz flash ERG response contains only the first harmonic in patients with no recordable OPs and both harmonics in patients with recordable OPs. This relationship between OPs and 20 Hz second component, that is possibly related to the activity of inner retina as well as the OPs, can demonstrate an alteration of the inner retina which evolves with distinct electrophysiological features from the ERG photoreceptor impairment.

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Retinitis pigmentosa and inner retina. Functional study by means of oscillatory potentials of the electroretinogram

Cited by 10 publications

References 18 publications

Partial and Full-Thickness Neuroretinal Transplants

Partial and Full-Thickness Neuroretinal Transplants

Human oscillatory potentials: intensity-dependence of timing and amplitude

Photopic ERG components in retinitis pigmentosa

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