Retinal Vessel Oxygen Saturation Increases After Vitrectomy

Lim, Laurence Shen; Tan, Leng Seow; Perera, Shamira A.

doi:10.1167/iovs.14-14152

Cited by 21 publications

(25 citation statements)

References 32 publications

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“…), and a similar study was published in the same year (Lim et al. ). The latter described an increase in oxygen saturation in both artery and vein after phacovitrectomy.…”

Section: Introductionmentioning

confidence: 53%

“…In the Lim et al. () study, all patients underwent both PPV and phacoemulsification. In our study, there is a different trend between the subgroups according to the lens status.…”

Section: Discussionmentioning

confidence: 99%

“…In the Lim et al. () study, all patients underwent both PPV and phacoemulsification, and the results cannot be compared with vitrectomy alone. The mechanism of increase in saturation values in patients with IOL and lower saturation values in patients with nuclear cataract is not clear and needs future investigation.…”

Section: Discussionmentioning

confidence: 99%

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The effect of pars plana vitrectomy and nuclear cataract on oxygen saturation in retinal vessels, diabetic and non‐diabetic patients compared

Šín

Chrapek

Karhanová

et al. 2015

Acta Ophthalmologica

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ABSTRACT.Purpose: To determine the effect of pars plana vitrectomy (PPV) on oxygen saturation in retinal vessels in patients with diabetes and non-diabetes after a 1-year follow-up. Methods: This was a prospective consecutive interventional case series in 82 eyes in 82 patients. The sample consisted of 25 patients with non-proliferative diabetic retinopathy with macular oedema based on vitreoretinal traction or epiretinal membrane (ERM) and 57 non-diabetic patients with macular hole and ERM. Automatic retinal oximetry (Oxymap Inc.) was used on all patients 24 hr prior to PPV, and it was also used 7 and 52 weeks after PPV (classic 20G or sutureless 23G). We analysed the data according to subgroup diagnosis and lens status. Results: Arterial saturation increased significantly from 96.4 AE 2.9% at baseline to 96.6 AE 3.4% at week 7 and 97.3 AE 3.4% at week 52 (p < 0.0001; Friedman test). Vein saturation also increased significantly from 63.5 AE 7.9% at baseline to 66.1 AE 7.7% and 67.0 AE 7.2% at weeks 7 and 52 (p < 0.0001; Friedman test). The value of the arteriovenous (A-V) difference decreased significantly after vitrectomy from 32.8 AE 7.5% at baseline to 30.5 AE 7.5% and 30.3 AE 7.0% at weeks 7 and 52 (p < 0.0001; Friedman test). The subgroup analysis revealed that in patients with diabetes, there were no statistically significant changes in oxygen saturation in blood vessels or in the A-V difference after PPV. After vitrectomy, retinal vessel diameter reduced by about 3.5% in both groups of patients. Further, the analysis revealed that opacification of the lens leads to a decrease in oxygen saturation in contrast to a clear lens and pseudophakic IOLs. Conclusion: Oxygen saturation is higher in the retinal veins and arteries after PPV in patients with non-diabetes, and this lasts for at least 52 weeks. In contrast, in patients with diabetes, there is no increase in oxygen saturation in the retinal vessels after vitrectomy. After vitrectomy, retinal vessel diameter reduced in both groups of patients. Further, the nuclear cataract progression has substantial effect on oximetry results. Patients with nuclear cataract exhibited an increase in saturation in both arteries and veins, but the A-V difference remained the same.

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“…), and a similar study was published in the same year (Lim et al. ). The latter described an increase in oxygen saturation in both artery and vein after phacovitrectomy.…”

Section: Introductionmentioning

confidence: 53%

“…In the Lim et al. () study, all patients underwent both PPV and phacoemulsification. In our study, there is a different trend between the subgroups according to the lens status.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of pars plana vitrectomy and nuclear cataract on oxygen saturation in retinal vessels, diabetic and non‐diabetic patients compared

Šín

Chrapek

Karhanová

et al. 2015

Acta Ophthalmologica

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“…In this study, oxygen saturation increased postoperatively by 2.8% in arteries and by 9.0% in veins, leading to a reduction in the A-V difference of 6.2%. With the use of the Oxymap T1, Lim et al7 and Šín et al8 reported similar findings that the retinal arterial and venous oxygen saturation were significantly increased after vitrectomy, leading to a decrease in the A-V difference. Based on previous reports and our current findings, retinal oxygen saturation increased in retinal arteries and further increased in retinal veins, and consequently, the A-V difference decreased.…”

Section: Discussionmentioning

confidence: 77%

“…In addition, previous studies have indicated that retinal oximetry is influenced by age, gender, and ethnicity (fundus pigmentation). Several investigators have reported the change in the retinal oximetry using the Oxymap T1 after vitreous surgery 7,8. To date, however, there is insufficient evidence with regard to the effect vitreous surgery has on retinal oximetry.…”

Section: Introductionmentioning

confidence: 99%

The effect of vitreomacular and cataract surgery on oxygen saturation in retinal vessels

Nakano¹,

Manabe²,

Osaka³

et al. 2017

OPTH

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PurposeTo evaluate the effects of vitreomacular and cataract surgery on retinal oximetry in vitreomacular disease.Patients and methodsThirty-eight eyes with epiretinal membrane (ERM) and 15 with idiopathic macular hole (MH) underwent 25 gauge pars plana vitrectomy combined with cataract surgery and intraocular lens implantation. Retinal oximetry was performed using the Oxymap T1 before, 1 month, and 6 months after surgery. Oxymap T1 simultaneously captures monochrome images of the fundus at two different wavelengths of light. Built-in Oxymap Analyzer software measures the oxygen saturation and vessel diameter.ResultsMean arterial oxygen saturation significantly increased from 96.8%±6.2% to 100.2%±5.8% at 1 month and to 99.6%±5.8% at 6 months after surgery (P<0.01). Mean venous oxygen saturation also significantly increased from 54.6%±7.5% to 61.2%±6.4% at 1 month and to 62.6%±5.9% at 6 months after surgery (P<0.01). Mean arteriovenous (A-V) difference decreased from 42.2%±6.6% to 39.0%±7.8% at 1 month and to 37.0%±6.9% at 6 months after surgery (P<0.01). The ERM and MH groups showed similar changes in retinal oxygen saturation. However, there were no significant changes in the caliber of major retinal vessels after surgery (from 125.2±15.2 μm to 124.0±15.4 μm in artery, from 168.7±14.6 μm to 169.8±14.6 μm in vein).ConclusionOxymap T1 was able to measure the increase in oxygen saturation in retinal arteries and veins, which led to a decrease in the A-V difference in oxygen saturation after vitrectomy combined with cataract surgery.

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Surgically induced changes in retinal vessel diameter, retinal nerve fibre layer thickness, and the optic disc after 23-gauge pars plana vitrectomy

2016

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The aim of the study is to investigate the retinal vascular calibre, retinal nerve fibre layer's thickness, and optic disc changes in patients after pars plana vitrectomy. We examined 40 eyes in 40 patients who had undergone unilateral pars plana vitrectomy at three time points: prior to surgery, and at 3 and 6 months after the operation. The diameters of central retinal arteries and veins were measured using retinal photographs. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were calculated using the revised Parr-Hubbard formula. Retinal nerve fibre layer thickness was obtained using Stratus optical coherence tomography. The cup-to-disc vertical ratio of the optic disc was evaluated using stereo optic disc photography. There were no significant differences between the eyes of individual patients before the operation. Cup-to-disc vertical ratios of the optic disc were significantly increased 3 and 6 months postoperatively (p < 0.01, p < 0.01), and there was a significant difference between the operative eye and fellow eye at the same time points (p < 0.01, p < 0.01). Changes in CRAE and CRVE in the operative eyes were significantly larger than the fellow eyes 6 months postoperatively (p < 0.01, p < 0.01). The retinal nerve fibre layer thickness showed no significant changes. While there were no changes in retinal nerve fibre layer thickness, vitrectomy induced changes in the cup-to-disc vertical ratio of the optic disc and retinal vessel diameter for at least 6 months after surgery.

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Retinal Vessel Oxygen Saturation Increases After Vitrectomy

Abstract: Retinal arterial and venous oxygen saturation are significantly increased after vitrectomy, while the AVD is decreased after vitrectomy.

Cited by 21 publications

References 32 publications

The effect of pars plana vitrectomy and nuclear cataract on oxygen saturation in retinal vessels, diabetic and non‐diabetic patients compared

The effect of pars plana vitrectomy and nuclear cataract on oxygen saturation in retinal vessels, diabetic and non‐diabetic patients compared

The effect of vitreomacular and cataract surgery on oxygen saturation in retinal vessels

Surgically induced changes in retinal vessel diameter, retinal nerve fibre layer thickness, and the optic disc after 23-gauge pars plana vitrectomy

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