Retinal vessel changes after laser treatment for retinopathy of prematurity

Kwon, Julie; Ghodasra, Devon H.; Karp, Karen A.; Ying, Gui‐Shuang; Wilson, Clare; Huang, Jiayan; Mills, Monte D.; Fielder, Alistair R.; Quinn, Graham E.

doi:10.1016/j.jaapos.2012.04.002

Cited by 8 publications

(8 citation statements)

References 13 publications

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“…Retinal surface maps from SDOCT scans in premature neonates could play a role in the evaluation of disease progression and in monitoring response to therapy. For example, Kwon et al reported a 20% decrease on vascular width after laser treatment 8 and thus, retinal surface map analysis before and after treatment of laser or anti-VEGFmay prove to be useful to the clinician.…”

Section: Discussionmentioning

confidence: 99%

“…7 Software applications such as ROPtool, RISA, CAIAR and ROPnet have been developed to accomplish this objective assessment from still photographs. 8,9 These software applications have shown tortuosity to be helpful in distinguishing between ROP stages and have found tortuosity to be positively correlated with ROP stage. 10 Investigators using ROPtool have also found large changes in tortuosity over time in individual eyes but only subtle changes in dilation.…”

Section: Introductionmentioning

confidence: 99%

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Three-Dimensional Assessment of Vascular and Perivascular Characteristics in Subjects with Retinopathy of Prematurity

et al. 2014

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Purpose To study vascular features detected with Spectral-Domain Optical Coherence Tomography (SDOCT) in subjects undergoing retinopathy of prematurity (ROP) screening. Design Cross-sectional study. Participants and Controls Fifty-seven premature neonates, 10 with plus disease in at least one eye and 47 without plus disease. Methods Bedside non-contact SDOCT imaging was performed after obtaining parental consent on 97 consecutive infants between January 2009 and September 2012. Fifty-seven subjects (31-49 weeks postmenstral age) who had a SDOCT scan in at least one eye containing the edge of the optic nerve and at least one major retinal vascular arcade were included. One eye per subject was randomly selected for analysis. Two masked graders evaluated scans for 1) retinal vessel elevation, 2) scalloped retinal layers, 3) hyporeflective vessels and 4) retinal spaces. To coalesce the weight of these features, a Vascular Abnormality Score by OCT (VASO) was created. For quantitative assessment of vessel elevation, retinal surface maps were created. Main Outcome Measures Prevalence of SDOCT vascular abnormalities, the VASO, inter-grader agreement, presence of elevation on surface maps. Results From among 67 SDOCT characteristics that were recorded, the most common characteristics found were vessel elevation (44%), hyporeflective vessels (40%), scalloped layers (22%) and retinal spaces (11%). Features significantly associated with plus disease were vessel elevation (p=0.01), hyporeflective vessels (p=0.04) and scalloped retinal layers (p=0.006). Intra-grader agreement was between 74-90% for all features. VASO was significantly higher in subjects with plus disease (p=0.0013). On three-dimensional SDOCT volumes, eyes with plus disease had greater retinal surface elevation which more often matched en face retinal vascular patterns. Conclusions We present a novel three-dimensional analysis of vascular and perivascular abnormalities identified in SDOCT images of eyes with ROP. SDOCT characteristics which are more common in eyes with plus disease provide the first in vivo demonstration of the effects of vascular dilation and tortuosity on perivascular tissue. The VASO and surface maps also delineate the severity of vascular pathology in plus disease. Further studies evaluating these findings in eyes with pre-plus versus with normal posterior pole vessels may determine the usefulness of SDOCT in early detection of vascular abnormalities in ROP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Assessment of Vascular and Perivascular Characteristics in Subjects with Retinopathy of Prematurity

et al. 2014

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“…, diabetic retinopathy) and systemic diseases ( e.g. , hypertension), which manifest themselves on the retina by altering vessel topological features, such as vessel width and tortuosity 1 2 3 4 5 6 . Analysis of retinal vessel thus holds great potential to assist the early diagnostics and treatment of these diseases.…”

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confidence: 99%

Smartphone-Based Accurate Analysis of Retinal Vasculature towards Point-of-Care Diagnostics

Ding

Wang

et al. 2016

Sci Rep

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Retinal vasculature analysis is important for the early diagnostics of various eye and systemic diseases, making it a potentially useful biomarker, especially for resource-limited regions and countries. Here we developed a smartphone-based retinal image analysis system for point-of-care diagnostics that is able to load a fundus image, segment retinal vessels, analyze individual vessel width, and store or uplink results. The proposed system was not only evaluated on widely used public databases and compared with the state-of-the-art methods, but also validated on clinical images directly acquired with a smartphone. An Android app is also developed to facilitate on-site application of the proposed methods. Both visual assessment and quantitative assessment showed that the proposed methods achieved comparable results to the state-of-the-art methods that require high-standard workstations. The proposed system holds great potential for the early diagnostics of various diseases, such as diabetic retinopathy, for resource-limited regions and countries.

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“…Computer-based image analysis has potential to address these limitations by providing objective and quantitative measures of retinal vessels. 8–9 The most recent issues of the Journal of AAPOS include three papers examining the role of digital image analysis for ROP care 10–12 that extend our understanding of these methods and their applications.…”

mentioning

confidence: 99%

“…Kwon and colleagues 10 applied the CAIAR system to narrow-angle images taken using a non-contact fundus camera (NM200D; Nidek, Aichi, Japan) to demonstrate that retinal vascular width and tortuosity decreased in eyes with type 1 ROP after laser photocoagulation. That is certainly not surprising, and it is consistent with what is seen clinically.…”

mentioning

confidence: 99%

Image analysis for retinopathy of prematurity: Where are we headed?

Chiang

2012

Journal of American Association for Pediatric Ophthalmology and

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Retinal vessel changes after laser treatment for retinopathy of prematurity

Cited by 8 publications

References 13 publications

Three-Dimensional Assessment of Vascular and Perivascular Characteristics in Subjects with Retinopathy of Prematurity

Three-Dimensional Assessment of Vascular and Perivascular Characteristics in Subjects with Retinopathy of Prematurity

Smartphone-Based Accurate Analysis of Retinal Vasculature towards Point-of-Care Diagnostics

Image analysis for retinopathy of prematurity: Where are we headed?

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