Retinal venous pressure in the non-affected eye of patients with retinal vein occlusions

Mozaffarieh, Maneli; Bärtschi, M.; Henrich, P. B.; Schoetzau, Andreas; Flammer, Josef

doi:10.1007/s00417-014-2617-3

Cited by 29 publications

(24 citation statements)

References 22 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Systemic risk factors affecting the vascular pathophysiology, such as HTN, diabetes, and atherosclerosis, have been suggested as possible mechanisms of damage in both glaucoma and RVO. The decreased ocular blood flow 28 and increased retinal venous pressure 29 in the fellow eyes of RVO patients compared with normal controls may be related to the pathogenesis of RVO and glaucoma. However, glaucoma and RVO are multifactorial diseases, and it is difficult to completely understand the vascular dysregulation related to the pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Changes in Peripapillary Microvasculature and Retinal Thickness in the Fellow Eyes of Patients With Unilateral Retinal Vein Occlusion: An OCTA Study

Shin

Nam

Lee

et al. 2019

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. To evaluate changes in peripapillary microvascular parameters in the fellow eyes of patients with unilateral retinal vein occlusion (RVO) using optical coherence tomography angiography (OCTA) and to determine the relationships between peripapillary microvasculature and retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness. METHODS. Eighty-three patients with unilateral RVO (50 patients with branch RVO and 33 with central RVO) and 83 normal controls were enrolled. OCTA (Cirrus HD-OCT 5000 with AngioPlex) 6 3 6-mm scans centered on the optic disc were acquired. Peripapillary vessel density (VD) and perfusion density (PD) were automatically calculated. RESULTS. The average RNFL and GC-IPL thicknesses in the fellow eyes of RVO patients were significantly thinner than in normal controls (93.5 vs. 96.6 lm, P ¼ 0.013 and 81.3 vs. 84.1 lm, P ¼ 0.003, respectively). In the fellow eyes of patients with unilateral RVO, the peripapillary VD of the inner ring, outer ring, and full area (17.47, 18.50, and 17.89, respectively) were significantly lower than those of controls (17.87, 18.87, and 18.27, respectively). The peripapillary PD of the inner ring, outer ring, and full area (0.456, 0.467, and 0.456, respectively) were also significantly lower than those of controls (0.468, 0.476, and 0.466, respectively). RNFL and GC-IPL thicknesses were correlated with both peripapillary VD and PD. CONCLUSIONS. OCTA revealed that peripapillary microvascular parameters in the fellow eyes of patients with unilateral RVO were decreased, and GC-IPL and RNFL thinning were also observed. The RNFL and GC-IPL thicknesses were positively correlated with both peripapillary VD and PD.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in Peripapillary Microvasculature and Retinal Thickness in the Fellow Eyes of Patients With Unilateral Retinal Vein Occlusion: An OCTA Study

Shin

Nam

Lee

et al. 2019

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…We applied arterial inlet pressure (50 6 6 mm Hg) and venous (17.7 6 6 mm Hg) 32 outlet pressure as boundary conditions to each LC network and each value was randomly selected from normal distributions (Table 1). Because there was no reported data on the arterial inlet pressure of the LC microcapillary network, we assumed the mean arterial inlet pressure to be 50 mm Hg, which would give an average blood flow velocity of approximately 1.0 mm/s 33 -a reasonable assumption for microcapillaries.…”

Section: Hemodynamics Boundary Conditionsmentioning

confidence: 99%

Factors Influencing Lamina Cribrosa Microcapillary Hemodynamics and Oxygen Concentrations

Chuangsuwanich

Birgersson

Thiéry

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. To identify and rank the lamina cribrosa (LC) morphologic factors that influence LC microcapillary hemodynamics and oxygen concentrations using computational fluid dynamics (CFD).METHODS. We generated 12,000 'artificial' LC microcapillary networks and predicted blood flow velocities and oxygen concentrations within the microcapillaries using CFD. Across models, we varied the average pore size of the LC (5500 6 2400 lm 2 ), the microcapillary arrangement (radial, isotropic, or circumferential), the LC diameter (1.9 6 0.3 mm), the inferior-superior curvature (340 6 116 m À1 ), and the nasal-temporal curvature (À78 6 130 m À1 ). We assumed that blood flow originated from the Circle of Zinn-Haller, fed the LC uniformly at its periphery, and was drained into the central retinal vein. Arterial (50 6 6 mm Hg) and venous (17.7 6 6 mm Hg) pressures were applied as boundary conditions and were also varied within our simulations. Finally, we performed linear regression analysis to rank the influence of each factor on LC hemodynamics and oxygen concentrations. RESULTS.The factors influencing LC hemodynamics and oxygen concentrations the most were: LC diameter, arterial pressure, and venous pressure, and to a lesser extent: the microcapillary arrangement (anisotropy) and nasal-temporal curvature. Lamina cribrosa pore size and superior-inferior curvature had almost no impact. Specifically, we found that LCs with a smaller diameter, a radial arrangement of the microcapillaries, an elevated arterial pressure and a decreased venous pressure had higher oxygen concentrations across their networks.CONCLUSION. This study described LC hemodynamics using a computational modeling approach. Our study may provide clinically relevant information for the understanding of ischemia-induced neuronal cell death in optic neuropathies.

show abstract

“…Therefore, IRD patient with FS may probably benefit from acupuncture treatment by stabilizing both the disturbed systemic and ocular blood flow. However, reduced macular edema following acupuncture may, in turn, be explained as a consequence of reduced retinal venous pressure, as increased venous pressure has been discussed in the pathogenetic chain of events of FS [48–50]. More precisely, in patients with simultaneous presentation of IRD and FS, increased venous pressure may probably lead to an increase in the transmural pressure and, thus, to increased risk of macula edema.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture benefits for Flammer syndrome in individuals with inherited diseases of the retina

2017

View full text Add to dashboard Cite

BackgroundPatients with inherited diseases of the retina (IRD) often exhibit signs and symptoms of Flammer syndrome (FS). Acupuncture treatment has shown its positive effect on visual function in patients with IRD. The aim of the present study is to examine the effect of acupuncture on signs and symptoms of FS in a cohort of patients suffering simultaneously FS and IRD.Patients and methodsA prospective pilot study was performed on 17 patients with FS and IRD: rod-cone dystrophy, Nr: 12 (RCD); cone-rod dystrophy, Nr: 3 (CRD) and inherited macular dystrophy, Nr: 2 (IMD; 12♀, 5♂; mean age: 44.19 y; SD ±17.09 y). Acupuncture treatment was done applying needle acupuncture of the body and the ears. The treatment was scheduled at 10 half-hour sessions over 5 weeks. Primary outcome was evaluation of the post-acupuncture effect on the signs and symptoms of FS in IRD patients using multiple-choice questionnaires.ResultsFollowing acupuncture, we found improvement in signs and symptoms of FS in patients suffering simultaneously IRD, as for instance (Nr. patients: improvement/suffering/total): a reduced tiredness (10/11/17), shorter sleep onset time (10/11/17), warmer feet and hands (10/10/17) and reduced frequency of headache attacks (9/11/17). Surprisingly, in four RCD patients and in one IMD patient, a reduction of macular edema was documented.ConclusionsThe applied acupuncture protocol for FS in IRD patients showed improvement in FS signs and symptoms and was tolerated well. Nevertheless, the objective evaluation of this complementary therapy on FS in IRD patients remains to be elucidated.

show abstract

Retinal venous pressure in the non-affected eye of patients with retinal vein occlusions

Abstract: In patients with CRVO, the RVP is increased in both the affected as well as in the unaffected contralateral eye.

Cited by 29 publications

References 22 publications

Changes in Peripapillary Microvasculature and Retinal Thickness in the Fellow Eyes of Patients With Unilateral Retinal Vein Occlusion: An OCTA Study

Changes in Peripapillary Microvasculature and Retinal Thickness in the Fellow Eyes of Patients With Unilateral Retinal Vein Occlusion: An OCTA Study

Factors Influencing Lamina Cribrosa Microcapillary Hemodynamics and Oxygen Concentrations

Acupuncture benefits for Flammer syndrome in individuals with inherited diseases of the retina

Contact Info

Product

Resources

About